gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Acetyl-CoA carboxylase alpha

Acetyl-CoA Carboxylase, CX3CL1, Fractalkine, Neurturin, CX3C
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, AMPK, V1a, Insulin, CAN
Papers using Acetyl-CoA Carboxylase antibodies
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Wu Gen Sheng, In PLoS ONE, 2001
... raptor (2280), phospho-raptor S792 (P-Raptor; 2083), p70 S6 kinase (S6K; 9202), phospho-S6K T389 (P-S6K; 9205), phospho-Acetyl-CoA carboxylase (P-ACC; 3661), and 14-3-3τ (9638) were purchased from Cell Signaling Technology ...
Banting lecture 1988. Role of insulin resistance in human disease
Kim Myung-Sunny et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1987
... Antibodies that recognize phosphorylated AMPK Thr172 and acetyl-CoA carboxylase (ACC) Ser79 were purchased from Cell Signaling Technology (Beverly, MA) and ...
Papers on Acetyl-CoA Carboxylase
Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth.
Robbins et al., Toronto, Canada. In Nat Immunol, Feb 2016
Finally, survival of resident arterial macrophages depends on a CX3CR1-CX3CL1 axis within the vascular niche.
Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA.
Heart et al., Cayey, Puerto Rico. In Am J Physiol Endocrinol Metab, Feb 2016
This protective action was associated with the TQ-dependent normalization of chronic accumulation of malonyl CoA, and elevation of acetyl CoA carboxylase (ACC), fatty acid synthase (FAS) and fatty acid binding proteins (FABPs) following chronic glucose overload.
Effects of dietary phosphate on glucose and lipid metabolism.
Taketani et al., Tokushima, Japan. In Am J Physiol Endocrinol Metab, Feb 2016
In addition, HP group also showed suppressed expression of hepatic lipogenic genes including sterol regulatory element binding protein-1c, fatty acid synthase, and acetyl-CoA carboxylase, whereas there was no difference in hepatic fat oxidation among the groups.
Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice.
Xu et al., Beijing, China. In Int J Mol Med, Feb 2016
Hence, in the present study, mice with lipopolysaccharide (LPS)‑induced ALI were used as a model to investigate the crosstalk between the CX3CL1-CX3CR1 axis and the nuclear factor (NF)-κB signaling pathway in the process of lung injury.
The role of CX3CL1 in fetal-maternal interaction during human gestation.
Gauster et al., İstanbul, Turkey. In Cell Adh Migr, Feb 2016
Amongst the group of chemokines, CX3CL1 (also known as fractalkine) has recently attracted attention in the field of reproductive research.
Chokeberry attenuates the expression of genes related to de novo lipogenesis in the hepatocytes of mice with nonalcoholic fatty liver disease.
Shin et al., Seoul, South Korea. In Nutr Res, Jan 2016
Compared with mice that were fed a high-fat diet, mice that were given 1% chokeberry powder exhibited significantly decreased mRNA expression of sterol regulatory element-binding protein (P=.009) and acetyl-CoA carboxylase (P=.0032) in the liver.
Molecular basis of multiple resistance to ACCase- and ALS-inhibiting herbicides in Alopecurus japonicus from China.
Wang et al., China. In Pestic Biochem Physiol, Jan 2016
It was shown via molecular analysis that resistance to both fenoxaprop-P-ethyl and mesosulfuron-methyl was due to an amino acid substitution of Ile1781 to Leu in acetyl-CoA carboxylase (ACCase) and a substitution of Trp 574 to Leu in ALS, respectively.
Effects of CX3CR1 and fractalkine chemokines in amyloid beta clearance and p-Tau accumulation in Alzheimer,s disease (AD) rodent models: Is fractalkine a systemic biomarker for AD?
Toledano-Díaz et al., Madrid, Spain. In Curr Alzheimer Res, Dec 2015
This anchored membrane FKN signalling might increase amyloid pathology while soluble fractalkine levels could prevent taupathies.
Chemokine Regulation of Neutrophil Infiltration of Skin Wounds.
Richmond et al., Xi'an, China. In Adv Wound Care (new Rochelle), Dec 2015
The responses of a number of CXC and CX3C chemokines and their receptors closely associate with the temporal and spatial recruitment of neutrophils to wound sites during the inflammatory phase and promote the clearance of necrotic neutrophils during the transition into the proliferative phase.
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Chen et al., Atlanta, United States. In Nat Cell Biol, Nov 2015
6PGD-mediated production of ribulose-5-phosphate (Ru-5-P) inhibits AMPK activation by disrupting the active LKB1 complex, thereby activating acetyl-CoA carboxylase 1 and lipogenesis.
Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
Tong et al., New York City, United States. In Nature, Nov 2015
Acetyl-CoA carboxylase (ACC) has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer and other diseases.
Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Garcia et al., Stanford, United States. In Science, Apr 2015
We report the crystal structure at 2.9 angstrom resolution of the human cytomegalovirus GPCR US28 in complex with the chemokine domain of human CX3CL1 (fractalkine).
Fractalkine Signaling and Microglia Functions in the Developing Brain.
Audinat et al., Paris, France. In Neural Plast, 2014
The neuronal chemokine fractalkine and its microglial receptor CX3CR1 are one important signaling pathway involved in these reciprocal interactions.
Obesity-Related Chronic Kidney Disease-The Role of Lipid Metabolism.
Power et al., Melbourne, Australia. In Metabolites, 2014
AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) are important regulators of fatty acid oxidation, which is frequently abnormal in the kidney with CKD.
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
Hodi et al., New Haven, United States. In Nature, 2014
Furthermore, responses were associated with T-helper type 1 (TH1) gene expression, CTLA4 expression and the absence of fractalkine (CX3CL1) in baseline tumour specimens.
Higher plasma fractalkine is associated with better 6-month outcome from ischemic stroke.
Becker et al., Seattle, United States. In Stroke, 2012
In contrast to our original hypothesis, lower concentrations of CX3CL1 are associated with worse stroke outcome
Fractalkine activates a signal transduction pathway similar to P2Y12 and is associated with impaired clopidogrel responsiveness.
Schäfer et al., Hannover, Germany. In Arterioscler Thromb Vasc Biol, 2012
increased fractalkine levels are associated with decreased endogenous platelet inhibition and impaired response to P2Y12 inhibition with clopidogrel.
siRNA knockdown of ADAM-10, but not ADAM-17, significantly reduces fractalkine shedding following pro-inflammatory cytokine treatment in a human adult brain endothelial cell line.
Woodroofe et al., Sheffield, United Kingdom. In Neurosci Lett, 2012
ADAM-10 is responsible for TNF-induced shedding of fractalkine from the cell membrane in human adult brain endothelial cell line.
Fractalkine stimulates cell growth and increases its expression via NF-κB pathway in RA-FLS.
Gu et al., Guangzhou, China. In Int J Rheum Dis, 2012
FKN up-regulates FKN mRNA expression in rheumatoid arthritis-fibroblast-like synoviocytes via the NF-kappaB pathway to stimulate cell proliferation.
Dual-level regulation of ACC synthase activity by MPK3/MPK6 cascade and its downstream WRKY transcription factor during ethylene induction in Arabidopsis.
Zhang et al., Hohhot, China. In Plos Genet, 2012
direct binding of WRKY33 to the W-boxes in the promoters of ACS2 and ACS6 genes in vivo, suggesting that WRKY33 is directly involved in the activation of ACS2 and ACS6 expression downstream of MPK3/MPK6 cascade in response to pathogen invasion
share on facebooktweetadd +1mail to friends