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Napsin A aspartic peptidase

abi1, NAPA, alpha-SNAP
The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, NSF, CAN, HAD, V1a
Papers on abi1
ABA-HYPERSENSITIVE BTB/POZ PROTEIN 1 functions as a negative regulator in ABA-mediated inhibition of germination in Arabidopsis.
Lee et al., Pusan, South Korea. In Plant Mol Biol, Feb 2016
High expression of AHT1 in dry seeds was inhibited by the defect of ABA signaling components such as ABI1, ABI3 and SRKs indicating that the expression of AHT1 is dependent on ABA signaling.
Red Wine Tannin Structure-Activity Relationships during Fermentation and Maceration.
Kennedy et al., In J Agric Food Chem, Feb 2016
Must and/or wine samples were collected throughout fermentation/maceration from five Napa Valley wineries.
BRI1-Associated Receptor Kinase 1 regulates guard cell ABA signaling mediated by Open Stomata 1 in Arabidopsis.
Nam et al., Seoul, South Korea. In Mol Plant, Jan 2016
We also showed that BAK1 and ABI1 oppositely regulate OST1 phosphorylation in vitro and that ABI1 interacts with BAK1 and inhibits the interaction of BAK1 and OST1.
Integration of C/N-nutrient and multiple environmental signals into the ABA signaling cascade.
Sato et al., Sapporo, Japan. In Plant Signal Behav, Jan 2016
Recently ABI1, a protein phosphatase type 2C (PP2C), was shown to be a regulator of C/N response in Arabidopsis plants.
Structural and mechanistic insights on nitrate reductases.
Romão et al., Caparica, Portugal. In Protein Sci, Dec 2015
The first crystal structure obtained for a NR was that of the monomeric NapA from Desulfovibrio desulfuricans in 1999.
An ABA down-regulated bHLH transcription repressor gene, bHLH129 regulates root elongation and ABA response when overexpressed in Arabidopsis.
Wang et al., Changchun, China. In Sci Rep, 2014
Quantitative RT-PCR results showed that ABA response of several genes involved in ABA signaling, including ABI1, SnRK2.2,
Transcriptome Analysis of Plant Hormone-Related Tomato (Solanum lycopersicum) Genes in a Sunlight-Type Plant Factory.
Fukuda et al., Sakai, Japan. In Plos One, 2014
In contrast, expression patterns of tomato ABI1 and OST1 had expression peak at different time.
Targeting proteins for proteasomal degradation-a new function of Arabidopsis ABI1 protein phosphatase 2C.
Ludwików, Poznań, Poland. In Front Plant Sci, 2014
Among the known effectors of ABA signaling, the ABI1 (abscisic acid-insensitive 1) protein phosphatase, which belongs to group A of the type 2C protein phosphatases, is recognized as a key component of the pathway.
Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors.
Backert et al., Erlangen, Germany. In Biomed Res Int, 2014
H. pylori factors such as LPS, HSP-60, NapA, DNA, and RNA are reported in various studies to be recognized by specific TLRs.
Functional and structural dynamics of NhaA, a prototype for Na(+) and H(+) antiporters, which are responsible for Na(+) and H(+) homeostasis in cells.
Padan, Jerusalem, Israel. In Biochim Biophys Acta, 2014
However the NhaA fold is unique and shared by ASBTNM [30] and NapA [29].
A two-domain elevator mechanism for sodium/proton antiport.
Drew et al., London, United Kingdom. In Nature, 2013
Here we describe the active-state structure of a Na(+)/H(+) antiporter, NapA from Thermus thermophilus, at 3 Å resolution, solved from crystals grown at pH 7.8.
Desmoglein-3 and Napsin A double stain, a useful immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes.
Kaya et al., Ankara, Turkey. In Appl Immunohistochem Mol Morphol, 2012
a useful immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes
The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.
Qian et al., Shanghai, China. In Nat Med, 2012
MiR-23b suppresses IL-17-, tumor necrosis factor alpha (TNF-alpha)- or IL-1beta-induced NF-kappaB activation and inflammatory cytokine expression by targeting TAB2, TAB3 and IKK-alpha.
DEXH box RNA helicase-mediated mitochondrial reactive oxygen species production in Arabidopsis mediates crosstalk between abscisic acid and auxin signaling.
Gong et al., Beijing, China. In Plant Cell, 2012
Two dominant-negative mutations in ABA insensitive1 (abi1-1) and abi2-1 greatly reduced ROS production in mitochondria.
E3B1/ABI-1 isoforms are down-regulated in cancers of human gastrointestinal tract.
Khanday et al., Jammu, India. In Dis Markers, 2011
Down-regulation of E3B1/ABI-1 expression in human carcinomas may play a critical role in tumor progression and in determining disease prognosis.
A membrane fusion protein αSNAP is a novel regulator of epithelial apical junctions.
Ivanov et al., Rochester, United States. In Plos One, 2011
novel roles for alphaSNAP in promoting the formation of epithelial adherens junctions and tight junctions by controlling golgi-dependent expression and trafficking of junctional proteins.
Structural basis of abscisic acid signalling.
Tanokura et al., Tokyo, Japan. In Nature, 2010
Here we present the crystal structures of the ABA receptor PYL1 bound with (+)-ABA, and the complex formed by the further binding of (+)-ABA-bound PYL1 with the PP2C protein ABI1.
In vitro reconstitution of an abscisic acid signalling pathway.
Zhu et al., Riverside, United States. In Nature, 2010
Here we show that by combining the recently identified ABA receptor PYR1 with the type 2C protein phosphatase (PP2C) ABI1, the serine/threonine protein kinase SnRK2.6/OST1 and the transcription factor ABF2/AREB1, we can reconstitute ABA-triggered phosphorylation of the transcription factor in vitro.
Regulators of PP2C phosphatase activity function as abscisic acid sensors.
Grill et al., Freising, Germany. In Science, 2009
regulatory component of abscissic acid (ABA)receptor 1(RCAR1, At1g01360) was shown to bind ABA, to mediate ABA-dependent inactivation of type 2C protein phosphatases (PP2Cs) ABI1 or ABI2 in vitro, and to antagonize PP2C action in planta
SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity.
Olofsson et al., Göteborg, Sweden. In Nat Cell Biol, 2007
Here, we show that lipid droplets are associated with proteins involved in fusion processes in the cell: NSF (N-ethylmaleimide-sensitive-factor), alpha-SNAP (soluble NSF attachment protein) and the SNAREs (SNAP receptors), SNAP23 (synaptosomal-associated protein of 23 kDa), syntaxin-5 and VAMP4 (vesicle-associated membrane protein 4).
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