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ATP-binding cassette, sub-family A

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: A2D, M-CSF, ACID, CsF, Gi
Papers on ABCA10
Enhancement of Aerosol Cisplatin Chemotherapy with Gene Therapy Expressing ABC10 protein in Respiratory System.
Brachmann et al., Coburg, Germany. In J Cancer, 2013
In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs(®) in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin.
A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival.
Smedby et al., Stockholm, Sweden. In Bmc Med Genet, 2013
The strongest association was observed for tightly linked SNPs on 17q24 near the ABCA10 and ABCA6 genes (rs10491178 HRrandom = 3.17, 95% CI 2.09-4.79,
Structure and Expression Analyses of SVA Elements in Relation to Functional Genes.
Kim et al., Pusan, South Korea. In Genomics Inform, 2013
LEPR (SVA-C), ALOX5 (SVA-D), PDS5B (SVA-D), and ABCA10 (SVA-F) genes also showed alternative transcripts by SVA exonization events.
ATP-binding cassette transporters in immortalised human brain microvascular endothelial cells in normal and hypoxic conditions.
Schlachetzki et al., Regensburg, Germany. In Exp Transl Stroke Med, 2011
However, slight decrease of ABCC1 in hypoxic and I/R samples and of ABCA10 and ABCD3 in I/R samples was observed.
Gene expression profiling of ABC transporters in dermal fibroblasts of pseudoxanthoma elasticum patients identifies new candidates involved in PXE pathogenesis.
Götting et al., Bad Oeynhausen, Germany. In Lab Invest, 2008
Seven genes (ABCA6, ABCA9, ABCA10, ABCB5, ABCC2, ABCC9 and ABCD2) were induced, whereas the gene expression of one gene (ABCA3) was decreased, comparing controls and PXE patients (with at least twofold changes).
Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor.
Terasaki et al., Sendai, Japan. In Biol Pharm Bull, 2007
The ATP binding cassette transporter subtype A5 (ABCA5)-like transporters ABCA5, ABCA6, ABCA8, ABCA9 and ABCA10 form a unique gene cluster within the ABC transporter superfamily, though their function is still poorly understood.
ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter.
Schmitz et al., Regensburg, Germany. In Biochem Biophys Res Commun, 2003
ABCA10 is a novel member of the group of ABCA6-like transporters involved in macrophage lipid homeostasis
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