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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

N-methylpurine-DNA glycosylase

The function of the encoded protein is not known. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: Hsp90, CAN, ACID, Akt, HAD
Papers using AAG antibodies
Global levels of histone modifications predict prognosis in different cancers
McPherson John Peter et al., In Genome Integrity, 2008
... CGT TCC AGT GTA TCT GCT GTC AG-3' and '5-TTC GTG GAC GAA GTC TTC AAG ATT GAG CG-3') or with a control shRNA plasmid (pRS-shGFP, non-effective, Origene), together with a vector conferring ...
Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. A review of pharmacological profile and clinical management of allergic rhinitis
Lazanas Marios C et al., In Journal of Inflammation (London, England), 2002
... 1-O-alkyl-2-sn-acetyl-glycerol (AAG) was purchased from BIOMOL International LP (Palatine House, ...
PAF: a review of its effects, antagonists and possible future clinical implications—part II
Demopoulos Constantinos Alexandros et al., In Mediators of Inflammation, 1990
... -acetyl-glycerol (AAG) was purchased from BIOMOL International, L.P., Palatine House, ...
High-performance liquid chromatographic analysis of platelet activating factor on a cation-exchange column by direct ultraviolet detection
Zabetakis Ioannis et al., In Lipids in Health and Disease, 1985
... -acetyl-glycerol (AAG) was purchased from BIOMOL International LP (Exeter, UK) ...
Papers on AAG
Epigenetic Regulation of the Blimp-1 Gene in B Cells Involves Bach2 and Histone Deacetylase 3.
Igarashi et al., Japan. In J Biol Chem, Feb 2016
We found that histone H3 and H4 around the Prdm1 intron 5 MARE were acetylated at higher levels in X63/0 plasma cells expressing Blimp-1 than in BAL17 mature B cells lacking its expression.
Evaluating the Substrate Selectivity of Alkyladenine DNA Glycosylase: The Synergistic Interplay of Active Site Flexibility and Water Reorganization.
Wetmore et al., In Biochemistry, Feb 2016
UNASSIGNED: Human alkyladenine DNA glycosylase (AAG) functions as part of the base excision repair (BER) pathway by cleaving the N-glycosidic bond that connects nucleobases to the sugar-phosphate backbone in DNA.
Low-energy Shock Wave Therapy Ameliorates Erectile Dysfunction in a Pelvic Neurovascular Injuries Rat Model.
Lue et al., San Francisco, United States. In J Sex Med, Jan 2016
LESW facilitates more complete re-innervation of penile tissue with regeneration of neuronal nitric oxide synthase (nNOS)-positive nerves from the MPG to the penis.
Methoxy polyethylene glycol-epoetin beta for the treatment of anemia associated with chronic renal failure.
Schmid, München, Germany. In Expert Rev Hematol, Jan 2016
Methoxy polyethylene glycol-epoetin beta (MPG-EPO), also called continuous erythropoietin receptor activator, is the longest acting erythropoiesis-stimulating agent currently available.
A fluorescence resonance energy transfer (FRET) based "Turn-On" nanofluorescence sensor using a nitrogen-doped carbon dot-hexagonal cobalt oxyhydroxide nanosheet architecture and application to α-glucosidase inhibitor screening.
Wu et al., Qufu, China. In Biosens Bioelectron, Jan 2016
Secondly, L-ascorbic acid-2-O-α-D-glucopyranosyl (AAG) was innovatively introduced as α-glucosidase substrate.
Semi-Mechanism-Based Population Pharmacokinetic Modeling of the Hedgehog Pathway Inhibitor Vismodegib.
Jin et al., San Francisco, United States. In Cpt Pharmacometrics Syst Pharmacol, Nov 2015
Vismodegib, approved for the treatment of advanced basal cell carcinoma, has shown unique pharmacokinetic (PK) nonlinearity and binding to α1-acid glycoprotein (AAG) in humans.
No surgery required: the future of feline sterilization: An overview of the Michelson Prize & Grants in Reproductive Biology.
Rhodes et al., Portland, United States. In J Feline Med Surg, Sep 2015
Recognizing the need to fund research and to attract researchers from the biomedical community to apply their expertise to this area, the Michelson Prize & Grants (MPG) in Reproductive Biology program was founded.
Pregnancy Recognition and Implantation of the Conceptus in the Mare.
Klein, Calgary, Canada. In Adv Anat Embryol Cell Biol, 2014
Following fertilization and initial development in the mare oviduct, selective transport of the embryo through the uterotubal junction driven by embryo-derived PGE2 occurs.
Methoxy polyethylene glycol-epoetin beta versus darbepoetin alfa for anemia in non-dialysis-dependent CKD: a systematic review.
Awaisu et al., Doha, Qatar. In Int J Clin Pharm, 2014
Different reviews have focused on evaluating the safety and efficacy of methoxy polyethylene glycol-epoetin beta (MPG-EPO), a continuous erythropoietin receptor activator, in CKD patients regardless of dialysis dependency and others have studied this novel agent exclusively in CKD patients receiving dialysis.
Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives.
Pae et al., Seoul, South Korea. In Expert Opin Ther Pat, 2013
Currently, several GM derivatives such as 17-AAG, 17-(2-dimethylaminoethyl)amino-17-demethoxygeldanamycin, IPI-493, and IPI-504 are being progressively developed toward clinical application.
DNA repair is indispensable for survival after acute inflammation.
Samson et al., Cambridge, United States. In J Clin Invest, 2012
ALKBH2 and ALKBH3 provide cancer protection similar to that of the DNA glycosylase AAG and display apparent epistasis with Aag
Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase.
Drennan et al., Cambridge, United States. In Biochemistry, 2012
Novel structures of AAG presented here help provide an understanding of this intriguing DNA repair protein, both in terms of understanding how AAG can recognize different types of DNA damage and in terms of how it may search the genome for DNA damage.
Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase.
Samson et al., Cambridge, United States. In Dna Repair (amst), 2012
The non-enzymatic binding of AAG to 3,N(4)-ethenocytosine specifically blocks ALKBH2-catalyzed repair of 3,N(4)-ethenocytosine but not that of methylated ALKBH2 substrates.
Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.
Guha et al., Toronto, Canada. In J Clin Invest, 2012
Evaluation of APNG protein levels in several clinical datasets demonstrated that in patients, high nuclear APNG expression correlated with poorer overall survival compared with patients lacking APNG expression.
Aberrant expression of N-methylpurine-DNA glycosylase influences patient survival in malignant gliomas.
Zhang et al., Beijing, China. In J Biomed Biotechnol, 2011
Investigated the expression of MPG gene and protein in 128 glioma and 10 non-neoplastic brain tissues. Found MPG gene expression level in glioma tissues was significantly higher than that in non-neoplastic brain tissues (P < 0.001).
Identification of aneuploidy-selective antiproliferation compounds.
Amon et al., Cambridge, United States. In Cell, 2011
We have identified the energy stress-inducing agent AICAR, the protein folding inhibitor 17-AAG, and the autophagy inhibitor chloroquine as exhibiting this property.
Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study.
Hudis et al., New York City, United States. In J Clin Oncol, 2008
PURPOSE: This phase I study examined whether a heat shock protein (Hsp) 90 inhibitor tanespimycin (17-AAG; KOS-953) could be administered safely in combination with trastuzumab at a dose that inhibits Hsp90 function in vivo in lymphocytes.
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.
Sobue et al., Nagoya, Japan. In Nat Med, 2005
We examined the therapeutic effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG), a potent Hsp90 inhibitor, and its ability to degrade polyglutamine-expanded mutant AR.
Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.
Wilson et al., Omaha, United States. In J Clin Oncol, 2005
PURPOSE: To determine the clinical toxicities of 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) given as a 1-hour infusion daily for 5 days every 3 weeks.
Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer.
Erlichman et al., Rochester, United States. In J Clin Oncol, 2005
PURPOSE: We determined the maximum-tolerated dose (MTD) and the dose-limiting toxicities (DLT) of 17-allylamino-17-demethoxygeldanamycin (17-AAG) when infused on days 1, 8, and 15 of a 28-day cycle in advanced solid tumor patients.
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