a G protein-coupled receptor
Sonidegib: First Global Approval.
Auckland, New Zealand. In Drugs, Sep 2015
SMO is a G protein-coupled receptor-like molecule that is essential for the actions of the Hedgehog family of secreted proteins, which play a critical role in the development and homeostasis of many organs and tissues.
Probing single biomolecules in solution using the anti-Brownian electrokinetic (ABEL) trap.
Stanford, United States. In Acc Chem Res, 2012
We have applied the ABEL trap method to explore the photodynamics and enzymatic properties of a variety of biomolecules in aqueous solution and present four examples: the photosynthetic antenna allophycocyanin, the chaperonin enzyme TRiC, a G protein-coupled receptor protein, and the blue nitrite reductase redox enzyme.
Endocrine regulation of male fertility by the skeleton.
New York City, United States. In Cell, 2011
By binding to a G protein-coupled receptor expressed in the Leydig cells of the testes, osteocalcin regulates in a CREB-dependent manner the expression of enzymes that is required for testosterone synthesis, promoting germ cell survival.