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SLU7 splicing factor homolog

9G8, Slu7, hSlu7, Slu7p
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SC35, CAN, STEP, SRp20, PRP16
Papers on 9G8
MAT- gene structure and mating behavior of Hymenoscyphus fraxineus and Hymenoscyphus albidus.
Gross et al., Zürich, Switzerland. In Fungal Genet Biol, Jan 2016
Furthermore, we present the complete mating type 1-1 locus of H. fraxineus and report the finding of three additional genes within this region; the as yet unobserved typical mating type gene MAT1-1-1, a DNA polymerase zeta catalytic subunit and a pre-mRNA-splicing factor SLU7.
Splicing regulator SLU7 is essential for maintaining liver homeostasis.
Berasain et al., In J Clin Invest, 2014
Slu7 governed the splicing and/or expression of multiple genes essential for hepatocellular differentiation, including serine/arginine-rich splicing factor 3 (Srsf3) and hepatocyte nuclear factor 4α (Hnf4α), and was critical for cAMP-regulated gene transcription.
The control of lipid metabolism by mRNA splicing in Drosophila.
Diangelo et al., Hempstead, United States. In Biochem Biophys Res Commun, 2014
Interestingly, while decreasing the SR protein 9G8 in the larval fat body yielded a similar triglyceride phenotype, its knockdown in the adult fat body resulted in a substantial increase in lipid stores.
Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.
Vijayraghavan et al., Bengaluru, India. In Mol Cell Biol, 2013
Here we report functions and interactions of the S. pombe slu7(+) (spslu7(+)) gene product, known from Saccharomyces cerevisiae and human in vitro reactions to assemble into spliceosomes after the first catalytic reaction and to dictate 3' splice site choice during the second reaction.
Highly pathogenic avian influenza virus nucleoprotein interacts with TREX complex adaptor protein Aly/REF.
Syed Hassan et al., Kuala Selangor, Malaysia. In Plos One, 2012
Conclusively, our study have opened new avenues for research of other cellular RNA export adaptors crucial in aiding viral RNA export such as the SRSF3, 9G8 and ASF/SF2 that may play role in influenza virus RNA nucleocytoplasmic transport.
Imaging of mRNA-protein interactions in live cells using novel mCherry trimolecular fluorescence complementation systems.
Cui et al., Wuhan, China. In Plos One, 2012
Another adapter protein, splicing factor 9G8, only interacted with intron-containing spliced M2 mRNA.
Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs.
Gruffat et al., Lyon, France. In Nucleic Acids Res, 2012
Using a yeast two-hybrid screen, we have identified three SR proteins, SF2/ASF, 9G8 and SRp20, as cellular partners of EB2.
Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10.
Liu et al., China. In Febs Lett, 2012
Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.
GENLES Network et al., Oklahoma City, United States. In Am J Hum Genet, 2012
Eleven additional replicated effects (5 × 10(-8) < p(meta-Euro) < 9.99 × 10(-5)) were observed with CFHR1, CADM2, LOC730109/IL12A, LPP, LOC63920, SLU7, ADAMTSL1, C10orf64, OR8D4, FAM19A2, and STXBP6.
Aberrant expression of splicing factors in newly diagnosed acute myeloid leukemia.
Wang et al., Nanchang, China. In Onkologie, 2011
MATERIAL AND METHODS: Using quantitative real-time polymerase chain reaction, we measured mRNA expression of 7 splicing factors belonging to the serine/arginine-rich (SR) protein family, SRSF1 (SF2/ASF), SRSF2 (SC35), SRSF3 (SRp20), SRSF4 (SRp75), SRSF5 (SRp40), SRSF6 (SRp55), and SRSF7 (9G8), and 1 non-SR factor, heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), in peripheral blood mononuclear cells of 26 patients with newly diagnosed AML and 26 healthy controls.
Compensatory signals associated with the activation of human GC 5' splice sites.
Vorechovsky et al., Southampton, United Kingdom. In Nucleic Acids Res, 2011
We show that efficient selection of this GC 5'ss required a high density of GAA/CAA-containing splicing enhancers in the exonized segment and was promoted by SR proteins 9G8, Tra2β and SC35.
Alterations of pre-mRNA splicing in human inflammatory bowel disease.
Rosenstiel et al., Kiel, Germany. In Eur J Cell Biol, 2011
To investigate these subtype-specific changes in detail we determined the expression levels of seven splicing factors (DUSP11, HNRPAB, HNRPH3, SLU7, SFR2IP, SFPQ, SF3B14) and three intron retention events (PARC, IER3, FGD2) in a cohort of 165 patients with inflammatory diseases of the colon (120 with IBD) and 30 healthy controls by real time PCR (TaqMan).
Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7.
Krebs et al., Edmonton, Canada. In Biochim Biophys Acta, 2011
RBM22 and hSlu7 differ significantly in their subcellular distributions under stress conditions, and RBM22 enhances the cytoplasmic translocation of hSlu7 under stress.
SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells.
Oudejans et al., Amsterdam, Netherlands. In Plos One, 2010
Upregulation of total tau expression (SFRS7-independent) and tau exon 10 splicing (SFRS7-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration.
SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs.
Sandri-Goldin et al., Irvine, United States. In Virology, 2010
The authors report that siRNA knockdown of SRp20 or 9G8 resulted in about a 10 fold decrease in herpes simplex virus 1 yields and in nuclear accumulation of polyA+ RNA.
HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8.
Goff et al., New York City, United States. In Mol Cell, 2009
eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11).
Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome.
Boris-Lawrie et al., Columbus, United States. In Retrovirology, 2008
Examples include a 5' UTR post-transcriptional control element (PCE), present in at least eight retroviruses, that interacts with cellular RNA helicase A to facilitate cap-dependent polyribosome association; and 3' UTR constitutive transport element (CTE) of Mason-Pfizer monkey virus that interacts with Tap/NXF1 and SR protein 9G8 to facilitate RNA export and translational utilization.
Mechanisms of fidelity in pre-mRNA splicing.
Reed, Boston, United States. In Curr Opin Cell Biol, 2000
Of particular note were the discoveries that the splicing factor U2AF(35) recognizes the AG dinucleotide at the 3' splice site early in spliceosome assembly, that a DEAD-box ATPase, Prp28, triggers specific rearrangements of the spliceosome, and that the splicing factor hSlu7 functions in the fidelity of AG choice during catalytic step II of splicing.
The RNA splicing factor hSlu7 is required for correct 3' splice-site choice.
Reed et al., Boston, United States. In Nature, 1999
Here we describe a metazoan splicing factor (hSlu7) that is required for selection of the correct AG.
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