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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

5-hydroxytryptamine receptor 1A

5-HT1A, X5-HT1A
Top mentioned proteins: TRIM32, CAN, HAD, V1a, 5-HT1B
Papers on 5-HT1A
Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder.
Koblan et al., Marlborough, United States. In Cns Spectr, Feb 2016
BACKGROUND: While extensive literature on the role of the serotonin receptor 1A (5-HT1A-R) in cognition exists, the findings are largely from animal studies.
Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine.
Halberstadt, San Diego, United States. In Pharmacol Biochem Behav, Feb 2016
5-MeO-DMT also disrupts PPI but the effect is primarily attributable to 5-HT1A activation.
Activation of 5-hyrdoxytryptamine 7 receptors within the rat nucleus tractus solitarii modulates synaptic properties.
Klinea et al., Columbia, United States. In Brain Res, Feb 2016
5-HT7 receptor-mediated changes in excitatory postsynaptic currents were also altered by block of 5-HT1A and GABAA receptors.
The Novel 5-HT1A Receptor Agonist, NLX-112 Reduces L-DOPA-induced Abnormal Involuntary Movements in Rat: a Chronic Administration Study with Microdialysis Measurements.
Newman-Tancredi et al., Groningen, Netherlands. In Neuropharmacology, Feb 2016
The highly selective and efficacious 5-HT1A receptor agonist, NLX-112 (befiradol or F13640) shows potent activity in a rat model of LID (suppression of Abnormal Involuntary Movements, AIMs) but its anti-AIMs effects have not previously been investigated following repeated administration.
FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression.
Fuxe et al., Stockholm, Sweden. In Trends Neurosci, Jan 2016
The discovery of brain fibroblast growth factor receptor 1 (FGFR1)-5 hydroxytryptamine receptor 1A (5-HT1A) heteroreceptor complexes, and their enhancement of neuroplasticity, offers an integration of these hypotheses at the molecular level.
Serotonin receptors in brain revisited.
Palacios, Barcelona, Spain. In Brain Res, Jan 2016
In order to provide further support to the existence of these receptors we performed quantitative autoradiographic mapping of the binding of several ligands for the 5-HT1 receptor labeling the subtypes 5-HT1A, 5-HT1B and 5-HT1C, and characterize pharmacologically these different receptors.
Verbal memory and 5-HT1A receptors in healthy volunteers - A PET study with [carbonyl-(11)C]WAY-100635.
Hietala et al., Lahti, Finland. In Eur Neuropsychopharmacol, Jan 2016
UNASSIGNED: The serotonin 5-HT1A receptor is a putative drug development target in disorders with cognitive and in particular memory deficits.
Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator.
Citrome et al., In Clin Schizophr Relat Psychoses, Dec 2015
Brexpiprazole acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A and at adrenergic alpha1B and alpha2C receptors.
New Pharmacotherapy Targeting Cognitive Dysfunction of Schizophrenia via Modulation of GABA Neuronal Function.
Kurachi et al., Kanazawa, Japan. In Curr Neuropharmacol, Dec 2015
In conclusion, a pharmacotherapy to alleviate abnormalities in GABA neurons through 5-HT1A agonists and T-817MA is expected to prevent the onset and/or progression of schizophrenia.
Phencyclidine-induced disruption of oscillatory activity in prefrontal cortex: Effects of antipsychotic drugs and receptor ligands.
Celada et al., Barcelona, Spain. In Eur Neuropsychopharmacol, Dec 2015
Atypical antipsychotic reversal may additionally involve 5-HT1A-R activation (but not 5-HT2A-R blockade) since 8-OH-DPAT and BAYx3702 (but not M100907) fully countered PCP effects.
Treatment for Hypoactive Sexual Desire.
Pfaus, Montréal, Canada. In Cell, Nov 2015
Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors.
Hippocampal 5-HT1A Receptor and Spatial Learning and Memory.
Stout et al., Melbourne, Australia. In Front Pharmacol, 2014
The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5-hydroxytryptamine; 5-HT) receptor binding sites, particularly of the 1A receptor (5-HT1A) subtype.
Enhanced aggressive behavior in mice lacking 5-HT1B receptor.
Hen et al., Strasbourg, France. In Science, 1994
However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors.
The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor.
Lefkowitz et al., Durham, United States. In Nature, 1988
We now report that the protein product of the genomic clone, G21, transiently expressed in monkey kidney cells has all the typical ligand-binding characteristics of the 5-hydroxytryptamine (5-HT1A) receptor.
Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock.
Green et al., In Nature, 1985
Recently a new drug, 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT), has been identified which shows high selectivity for binding to 5-HT1 (possibly 5-HT1A) receptors and which binds to presynaptic serotonin autoreceptors in some regions of rat brain.
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