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Eukaryotic translation initiation factor 4E binding protein 1

4E-BP1, BPI, bactericidal/permeability-increasing protein, BP1
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: mTOR, Akt, p70S6K, CAN, mTORC1
Papers using 4E-BP1 antibodies
mTORC1 signaling: what we still don’t know
Tajmir-Riahi Heidar-Ali, In PLoS ONE, 2010
... Antibodies against LC3B, p62/SQSTM1, beclin-1, phospho-mTOR (Ser2448), mTOR, phospho-4E-BP1 (Thr37/46), and 4E-BP-1 were obtained from Cell Signaling (New England Biolabs, Hertfordshire, ...
Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs
Habermann T M et al., In Leukemia, 2009
... Antibodies for phosphorylated mTOR (Ser 2448), S6 ribosomal protein (Ser 235/236) and 4E-BP1 (Thr37/46) were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
An ATP-competitive mTOR inhibitor reveals rapamycin-insensitive functions of mTORC1
Yamori Takao et al., In Proteome Science, 2008
... ], and total-4E-BP1 [25] were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1
Huang Shile et al., In Laboratory investigation; a journal of technical methods and pathology, 2007
... AMPKα, phospho-S6K1 (Thr389), S6K1 (all from Santa Cruz Biotechnology, Santa Cruz, CA); 4E-BP1 (Zymed Laboratories, South San Francisco, CA); Phosphotyrosine (BD Biosciences, San Jose, CA); ...
Identification of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene
Fu Sidney W. et al., In International Journal of Biological Sciences, 2004
... The membrane was incubated overnight with either BP1 (NB 100-481) rabbit polyclonal antibody (Novus Biologicals) at a dilution of 1:5,000 ...
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Papers on 4E-BP1
Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification.
Levi et al., Ann Arbor, United States. In Ann Surg, Feb 2016
Bone-cartilage-stromal progenitor cells (CD105+/AlphaV+/Tie2-/CD45-/CD90-/BP1-) were also significantly decreased after lymph node excision (10.2% vs 0.5%, P < 0.05).
Suppression of host PTEN gene expression for Leishmania donovani survival in Indian Visceral Leishmaniasis.
Sundar et al., Benares, India. In Microbes Infect, Feb 2016
Expression of pten and other genes in vicinity egr1 &4e-bp1 were evaluated in splenic tissue before and after treatment in visceral leishmaniasis patients.
DLX4 hypermethylation is a prognostically adverse indicator in de novo acute myeloid leukemia.
Qian et al., Zhenjiang, China. In Tumour Biol, Feb 2016
UNASSIGNED: Hypermethylation of distal-less homeobox 4 (DLX4) has been increasingly identified in several cancers.
Organic UV Filters in the Surface Water of Nanjing, China: Occurrence, Distribution and Ecological Risk Assessment.
Li et al., Nanjing, China. In Bull Environ Contam Toxicol, Feb 2016
The results indicated butyl-methoxydibenzoylmethane, octyl-dimethyl-PABA and benzophenone-types (BP3, BP4 and BP1) were the most frequently detected compounds at concentrations of 3.63-104 ng/L.
Upregulation of Bpifb1 expression in the parotid glands of non-obese diabetic mice.
Shimomura-Kuroki et al., Niigata, Japan. In Oral Dis, Jan 2016
OBJECTIVE: To define the increased mRNA expression of Bpifb1, a member of the bactericidal/permeability-increasing protein family, in parotid acinar cells from non-obese diabetic (NOD) mice, an animal model for Sjögren's syndrome.
Randomized Multicenter Placebo-Controlled Trial of Omega-3 Fatty Acids for the Control of Aromatase Inhibitor-Induced Musculoskeletal Pain: SWOG S0927.
Moinpour et al., Seattle, United States. In J Clin Oncol, Jul 2015
PATIENTS AND METHODS: Women with early-stage breast cancer receiving an AI who had a worst joint pain/stiffness score ≥ 5 of 10 using the Brief Pain Inventory-Short Form (BPI-SF) were randomly assigned to receive either O3-FAs 3.3 g or placebo (soybean/corn oil) daily for 24 weeks.
Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors.
Ligibel et al., New Haven, United States. In J Clin Oncol, May 2015
PATIENTS AND METHODS: Eligibility criteria included receiving an AI for at least 6 months, reporting ≥ 3 of 10 for worst joint pain on the Brief Pain Inventory (BPI), and reporting < 90 minutes per week of aerobic exercise and no strength training.
Complex de novo chromosomal rearrangement at 15q11-q13 involving an intrachromosomal triplication in a patient with a severe neuropsychological phenotype: clinical report and review of the literature.
Finelli et al., Milano, Italy. In Am J Med Genet A, 2015
Array comparative genomic hybridization (CGH) analysis identified a heterozygous duplication of 1.1 Mb at 15q11.2 (between low-copy repeats BP1 and BP2), and a heterozygous triplication of 6.8 Mb at 15q11.2-q13.1 (BP2-BP4).
Antimicrobial Peptides in Human Sepsis.
Schuerholz et al., Aachen, Germany. In Front Immunol, 2014
The bactericidal/permeability-increasing protein (BPI) attenuates local inflammatory response and decreases systemic toxicity of endotoxins.
The 15q11.2 BP1-BP2 microdeletion syndrome: a review.
Butler et al., Kansas City, United States. In Int J Mol Sci, 2014
BP1-BP2 microdeletion can present with developmental and language delay, neurobehavioral disturbances and psychiatric problems.
MYC-mediated synthetic lethality for treatment of hematological malignancies.
Huang et al., Wuhan, China. In Curr Cancer Drug Targets, 2014
Many small molecule inhibitors (SMIs) have been proven to induce MYC-SL by targeting AUK-B, Brd4, CDK1, CHK1, MCL-1, the mTOR/4E-BP1/eIF4E pathway, and PIM1/2.
[Bullous pemphigoid--a cause of itching of the skin with increasing incidence].
Tasanen et al., In Duodecim, 2014
Immunofluorescence analysis on perilesional skin is used in the diagnostics and serum BP1 80 levels parallel the disease activity.
CNVs conferring risk of autism or schizophrenia affect cognition in controls.
Stefansson et al., Reykjavík, Iceland. In Nature, 2014
deletion between breakpoints 1 and 2 (15q11.2(BP1-BP2)
The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity.
Schumann et al., Berlin, Germany. In Immunity, 2013
Several structural differences were observed between LBP and the related bactericidal/permeability-increasing protein (BPI), and the LBP C-terminal domain contained a negatively charged groove and a hydrophobic "phenylalanine core."
Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2α phosphorylation and 4E-BP1 dephosphorylation.
Yano et al., Kumamoto, Japan. In Exp Cell Res, 2012
The nsPEF exposure caused a rapid decrease in 4E-BP1 phosphorylation irrespective of the PERK/GCN2 status, suggesting participation of both eIF2alpha and 4E-BP1 in nsPEF-induced translational suppression.
Attenuation of acute graft-versus-host disease in the absence of the transcription factor RORγt.
Serody et al., Chapel Hill, United States. In J Immunol, 2012
CD4(+) T cell expression of RORgammat is important in the pathogenesis of acute Graft-versus-host disease.
Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice.
Takahashi et al., Tsukuba, Japan. In Eur J Immunol, 2012
These results suggest that ROR-gamma-t plays important roles in the development of plasmacytosis and autoantibody production.
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells.
Cua et al., Palo Alto, United States. In Nat Med, 2012
IL-23 is essential in enthesitis and acts on previously unidentified IL-23 receptor (IL-23R)(+), RAR-related orphan receptor gammat (ROR-gammat)(+)CD3(+)CD4(-)CD8(-), entheseal resident T cells.
Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice.
Becher et al., Zürich, Switzerland. In J Clin Invest, 2012
RORgammat(+) innate lymphocytes and gammadelta T cells are necessary and sufficient for psoriatic plaque formation
Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia.
Baker et al., Memphis, United States. In J Clin Oncol, 2011
Sorafenib inhibited the phosphorylation of AKT, S6 ribosomal protein, and 4E-BP1 in leukemia cells.
More papers using 4E-BP1 antibodies
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
Carpenter G H et al., In Cell Death & Disease, 2001
... Anti-4E-BP1 (Y329) (1:2000 for western blotting) was obtained from Abcam (Abcam plc, Cambridge, UK), ...
Chlorpromazines and cancer
Rho Seung Bae et al., In Apoptosis, 1971
... anti-phospho-p70S6K(Thr 421) (BDPhamingen, San Diego, CA), anti-p21 and anti-p27 (Oncogene, San Diego, CA), anti-4E-BP1 and anti-phospho-4E-BP1 (Cell Signaling) and anti- ...
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