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Actin related protein 2/3 complex, subunit 4

20-kDa, CBP20, SAE1
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, V1a
Papers on 20-kDa
Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA.
Eichler et al., Seattle, United States. In Am J Hum Genet, Feb 2016
In addition, we provide evidence of gene-disruptive CNVs (in DISC1, WNT7A, RBFOX1, and MBD5), as well as smaller de novo CNVs and exon-specific SNVs missed by exome sequencing in neurodevelopmental genes (e.g., CANX, SAE1, and PIK3CA).
Purification and characterization of oligonucleotide binding (OB)-fold protein from medicinal plant Tinospora cordifolia.
Hassan et al., New Delhi, India. In J Chromatogr B Analyt Technol Biomed Life Sci, Feb 2016
We observed a single band of 20-kDa on SDS-PAGE.
A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle.
Walsh et al., Calgary, Canada. In Mol Pharmacol, Jan 2016
This effect was reversed following washout of HS38 and correlated with a reduction in the rate of phosphorylation of myosin 20-kDa regulatory light chains (LC20) but not of protein kinase C-potentiated inhibitory protein for myosin phosphatase of 17 kDa (CPI-17), prostate apoptosis response-4, or myosin phosphatase-targeting subunit 1 (MYPT1), all of which have been implicated in the regulation of vascular contractility.
The N-terminal motif of PMP70 suppresses cotranslational targeting to the endoplasmic reticulum.
Sakaguchi et al., Akō, Japan. In J Biochem, Jan 2016
The 50-kDa and 20-kDa proteins were crosslinked with the motif.
Endostatin's emerging roles in angiogenesis, lymphangiogenesis, disease, and clinical applications.
Azar et al., Chicago, United States. In Biochim Biophys Acta, Dec 2015
Endostatin, a 20-kDa C-terminal fragment of type XVIII collagen, is one of the most potent inhibitors of angiogenesis.
Analyzing the influence of PEG molecular weight on the separation of PEGylated gold nanoparticles by asymmetric-flow field-flow fractionation.
McNeil et al., Frederick, United States. In Anal Bioanal Chem, Nov 2015
The optimized asymmetric-flow field-flow fractionation technique using in-line multiangle light scattering, dynamic light scattering, refractive index, and UV-vis detectors allowed successful separation and detection of a mixture of nanoparticles coated with 2-, 5-, 10-, and 20-kDa PEG.
MYC-mediated synthetic lethality for treating tumors.
Huang et al., Wuhan, China. In Curr Cancer Drug Targets, 2014
An SMI can also induce MYC-SL by decreasing MYC expression through the activation of the GSK3β/FBW7 axis, the inactivation of PP2A inhibitors, and the inhibition of ARK5, AUK-A, Brd4, CDK1, CDK2, CHK1, and SAE1/2.
Small ubiquitin-like modifier (SUMO) modification of E1 Cys domain inhibits E1 Cys domain enzymatic activity.
Chen et al., Duarte, United States. In J Biol Chem, 2012
Data show that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was catalyzed by Ubc9 at several additional Lys residues surrounding the catalytic Cys-173 of SAE2.
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.
Westbrook et al., Houston, United States. In Science, 2012
loss of SAE1/2 activity drives synthetic lethality with Myc; inactivation of SAE2 leads to mitotic catastrophe and cell death upon Myc hyperactivation; findings in Myc-high breast cancers suggest low tumor SAE1 and SAE2 correlates metastasis-free survival
Prevention of chemotherapy-induced neutropenia with pegfilgrastim: pharmacokinetics and patient outcomes.
Green et al., Thousand Oaks, United States. In Chemotherapy, 2011
To eliminate the burden of daily filgrastim injection, pegfilgrastim, a long-acting form of filgrastim, was developed by covalently attaching a 20-kDa polyethylene glycol molecule to filgrastim to increase molecular size and thus reduce renal elimination.
Vascular smooth muscle myosin light chain diphosphorylation: mechanism, function, and pathological implications.
Walsh, Calgary, Canada. In Iubmb Life, 2011
Smooth muscle contraction is activated primarily by phosphorylation at S19 of the 20-kDa regulatory light chain subunits of myosin II (LC(20) ) catalyzed by Ca(2+) /calmodulin-dependent myosin light chain kinase.
The structure of human cleavage factor I(m) hints at functions beyond UGUA-specific RNA binding: a role in alternative polyadenylation and a potential link to 5' capping and splicing.
Doublié et al., Burlington, United States. In Rna Biol, 2011
Our study illustrated the molecular basis for UGUA recognition by the CFI(m) complex, suggested a possible mechanism for CFI(m) mediated alternative polyadenylation, and revealed potential links between CFI(m) and other mRNA processing factors, such as the 20 kDa subunit of the cap binding protein (CBP20), and the splicing regulator U2AF65.
Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme.
Melchior et al., Heidelberg, Germany. In Mol Biol Cell, 2011
The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 and in Uba2, and demonstrate that their import is mediated by importin alpha/beta in vitro and in intact cells.
New phenotypes of the drought-tolerant cbp20 Arabidopsis thaliana mutant have changed epidermal morphology.
Papp et al., Hungary. In Plant Biol (stuttg), 2011
Some hitherto undescribed changes were found in the tissue structure and epidermal morphology of cbp20 mutant
Binding properties and dynamic localization of an alternative isoform of the cap-binding complex subunit CBP20.
Neugebauer et al., Dresden, Germany. In Nucleus, 2010
A novel alternative splice variant of CBP20, termed CBP20S, has an in-frame deletion, leading to the translation of a protein lacking most of the RNA recognition motif (RRM).
Identification of the pollen self-incompatibility determinant in Papaver rhoeas.
Franklin-Tong et al., Birmingham, United Kingdom. In Nature, 2009
PrpS encodes a novel approximately 20-kDa protein.
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
Maquat, Rochester, United States. In Nat Rev Mol Cell Biol, 2004
Complex-loaded mRNA is thought to undergo a pioneer round of translation when still bound by cap-binding proteins CBP80 and CBP20 and poly(A)-binding protein 2. The acquisition and loss of mRNA-associated proteins accompanies the transition from the pioneer round to subsequent rounds of translation, and from translational competence to substrate for nonsense-mediated mRNA decay.
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20.
Maquat et al., Rochester, United States. In Cell, 2001
We defined other components of NMD-susceptible mRNP as CBP20, PABP2, eIF4G, and the NMD factors Upf2 and Upf3.
Mechanisms of smooth muscle contraction.
Morgan et al., Boston, United States. In Physiol Rev, 1996
Work performed with differentiated contractile smooth muscle tissue over the last two decades has made clear that covalent modification of myosin by phosphorylation of the 20-kDa myosin light chains is a significant mode of regulation of contractile activity in smooth muscle, particularly in regard to the generation of phasic contractions and the initial development of tonic contractions.
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