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Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

14-3-3zeta, YWHAZ
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: GAPDH, TBP, CAN, SET, POLYMERASE
Papers on 14-3-3zeta
Identification of Suitable Reference Genes for Peripheral Blood Mononuclear Cell Subset Studies in Multiple Sclerosis.
Romme Christensen et al., Copenhagen, Denmark. In Scand J Immunol, Jan 2016
Eight candidate reference genes (CASC3, EEF1A1, GAPDH, HPRT1, RPLP0, UBC, UBE2D2 and YWHAZ) were analysed using normfinder and genorm algorithms to identify the most stably expressed genes.
Reference genes for valid gene expression studies on rat dental, periodontal and alveolar bone tissue by means of RT-qPCR with a focus on orthodontic tooth movement and periodontitis.
Römer et al., Regensburg, Germany. In Ann Anat, Jan 2016
RESULTS: PPIB/YWHAZ were the most stabile reference genes for the combined dental, periodontal and alveolar bone tissue of the rat overall, in untreated animals and rats with additional periodontitis, whereas PPIB/B2M performed best in orthodontically treated rats with YWHAZ ranking third.
Steroid Receptors and Aromatase Gene Expression in Different Brain Areas of Copulating and Sexually Sluggish Male Rats.
Paredes et al., Mexico. In J Sex Med, Dec 2015
Cyclophilin A (CycA) and tyrosine 3-monooxygenase-tryptophan activation protein zeta (Ywhaz) were housekeeping genes used to determine relative gene expression with the 2(-ΔΔCt) method.
Altered expression of microRNA-451 in eutopic endometrium of baboons (Papio anubis) with endometriosis.
Fazleabas et al., Grand Rapids, United States. In Hum Reprod, Dec 2015
In the baboon, induction of endometriosis significantly decreased the expression of miR-451 at 3 months (P < 0.001), which was also associated with increased expression of its target gene YWHAZ (14.3.3ζ).
Importance of reference gene selection for articular cartilage mechanobiology studies.
Blain et al., Cardiff, United Kingdom. In Osteoarthritis Cartilage, Dec 2015
DESIGN: The expression of eight commonly used reference genes (18s, ACTB, GAPDH, HPRT1, PPIA, RPL4, SDHA and YWHAZ) was determined by qPCR and data compared using four software packages (comparative delta-Ct method, geNorm, NormFinder and BestKeeper).
Development of a Gene Expression Assay for the Diagnosis of Mycobacterium bovis Infection in African Lions (Panthera leo).
Parsons et al., Stellenbosch, South Africa. In Transbound Emerg Dis, Nov 2015
The abundance of monokine induced by gamma interferon (MIG/CXCL9) mRNA, measured in relation to that of YWHAZ, was used as a marker of ESAT-6/CFP-10 sensitization.
Evaluation of reference genes for gene expression studies in human brown adipose tissue.
Svensson et al., Göteborg, Sweden. In Adipocyte, Oct 2015
Seven genes (FAM96B, GNB1, GNB2, HUWE1, PSMB2, RING1 and TPT1) identified by microarray analysis, and 8 commonly used reference genes (18S, B2M, GAPDH, LRP10, PPIA, RPLP0, UBC, and YWHAZ) were selected and further analyzed by quantitative PCR in both BAT containing perirenal adipose tissue and subcutaneous adipose tissue.
Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE.
Haavik et al., Bergen, Norway. In Am J Med Genet B Neuropsychiatr Genet, Aug 2015
The results show suggestive epistasis between YWHAE and two other 14-3-3-genes - YWHAZ, YWHAQ - in aADHD (nominal P-value of 0.0005 and 0.0008, respectively).
Identification of Suitable Reference Genes for Normalization of Real-Time Quantitative Polymerase Chain Reaction in an Intestinal Graft-Versus-Host Disease Mouse Model.
Xu et al., Xuzhou, China. In Transplant Proc, Jul 2015
Transcription levels of 9 candidate genes, B2M, SDHA, HPRT, ACTB, GAPDH, HMBS, TBP, YWHAZ, and RPLP0, in each tissue were measured with the use of RT-qPCR.
Transcription factor KLF4 regulates microRNA-544 that targets YWHAZ in cervical cancer.
Lu et al., Shanghai, China. In Am J Cancer Res, 2014
In addition, we found that miR-544 directly targets the YWHAZ oncogene and functions as a tumor suppressor in cervical cancer cells.
Selection of suitable reference genes for normalization of quantitative RT-PCR in peripheral blood samples of bottlenose dolphins (Tursiops truncatus).
Yang et al., Davis, United States. In Sci Rep, 2014
Seventy-five blood samples collected from 7 bottlenose dolphins were used to analyze 15 candidate HKGs (ACTB, B2M, GAPDH, HPRT1, LDHB, PGK1, RPL4, RPL8, RPL18, RPS9, RPS18, TFRC, YWHAZ, LDHA, SDHA).
Reference genes for reverse transcription quantitative PCR in canine brain tissue.
Penning et al., Utrecht, Netherlands. In Bmc Res Notes, 2014
RESULTS: Following the minimum information for publication of quantitative real-time PCR experiments precise guidelines, the expression of ten frequently used reference genes, namely YWHAZ, HMBS, B2M, SDHA, GAPDH, HPRT, RPL13A, RPS5, RPS19 and GUSB was evaluated in seven brain regions (frontal lobe, parietal lobe, occipital lobe, temporal lobe, thalamus, hippocampus and cerebellum) and whole brain of healthy dogs.
Bioinformatics Analysis of the Effects of Tobacco Smoke on Gene Expression.
Zou et al., Shanghai, China. In Plos One, 2014
In the PPI network, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (YWHAZ), and CYP1A1 were hub genes.
c-abl and YWHAZ gene expression in gastric cancer.
Vîlcea et al., Craiova, Romania. In Rom J Morphol Embryol, 2014
This study aims to determine the gene expression for c-abl and YWHAZ in gastric cancer and the differences between the c-abl and YWHAZ gene expression inside the tumor versus healthy tissue (at the resection edges).
Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions.
Landry et al., Bordeaux, France. In Embo J, 2012
In the dorsal spinal cord of neuropathic rats, 14-3-3zeta is overexpressed and weakens GABAB inhibition.
Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20).
Gusev et al., Moscow, Russia. In Arch Biochem Biophys, 2012
cofilins 1 and 2 only weakly interact with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3 zeta
Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.
Schwarz et al., Adelaide, Australia. In Mol Psychiatry, 2012
data provide the first evidence of a direct role for 14-3-3 zeta deficiency in the aetiology of neurodevelopmental disorders andas a central risk factor in schizophrenia.
Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription.
Ron et al., San Francisco, United States. In J Biol Chem, 2012
the function of nuclear RACK1 is mediated through its interaction with 14-3-3zeta
14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells.
Ge et al., Wuhan, China. In Plos One, 2011
Findings show that multiple signaling events impinge on Stat3 and that 14-3-3zeta serves as an essential coordinator for different pathways to regulate Stat3 activation and function in multiple myeloma cells.
Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer.
Wang et al., Boston, United States. In Nat Med, 2010
SiRNA-mediated knockdown of either of two of these genes, the antiapoptotic gene YWHAZ and a lysosomal gene LAPTM4B, sensitized tumor cells to anthracyclines, and overexpression of either of the genes induced anthracycline resistance.
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