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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


14-3-3sigma, SFN, D15S9
This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: Nrf2, CAN, V1a, PrP, HAD
Papers on 14-3-3sigma
Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-κB-dependent pathway downregulating MGMT expression.
Yue et al., Tianjin, China. In Int J Oncol, Feb 2016
We elucidated the mechanisms of sulforaphane (SFN) reverse TMZ resistance in TMZ-inducing cell lines by inhibiting nuclear factor-κB (NF-κB) transcriptional activity.
Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes.
Jacobs et al., Hilo, United States. In Pharm Biol, Feb 2016
To test for subsequent resistance to oxidative stress, cells were pretreated with 50 μM FKA, 10 μM FKB or 10 μM sulphoraphane (SFN) for 24 h, followed by 0.4-2.8
Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress.
Chen et al., Guangzhou, China. In Acta Pharmacol Sin, Feb 2016
Meanwhile, SFN significantly alleviated the damage of ΔΨm and decreased the expression of ER stress-related apoptosis proteins (GRP78, CHOP and caspase-12), elevating the expression of SIRT1 and Bcl-2/Bax ratio in the cardiomyocytes.
Anabolic and anti-resorptive modulation of bone homeostasis by the epigenetic modulator sulforaphane, a naturally occurring isothiocyanate.
van Wijnen et al., United States. In J Biol Chem, Feb 2016
Here we show that sulforaphane (SFN), a naturally occurring isothiocyanate, promotes osteoblast differentiation by epigenetic mechanisms.
Sulforaphane Prevents Methylmercury-Induced Oxidative Damage and Excitotoxicity Through Activation of the Nrf2-ARE Pathway.
Xu et al., Shenyang, China. In Mol Neurobiol, Feb 2016
Here, we explored the interaction between oxidative damage and excitotoxicity and evaluated the preventive effects of sulforaphane (SFN) on MeHg-induced neurotoxicity in rat cerebral cortex.
Novel immunohistochemical markers differentiate intrahepatic cholangiocarcinoma from benign bile duct lesions.
Baba et al., Essen, Germany. In J Clin Pathol, Feb 2016
Our previously identified biomarkers (stress-induced phosphoprotein 1 (STIP1), SerpinH1, 14-3-3Sigma) were tested immunohistochemically following comparison with candidates from the literature (cluster of differentiation 56, heat shock protein (HSP)27, HSP70, B-cell-lymphoma2, p53, ki67).
The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane.
Eckert et al., Baltimore, United States. In Mol Carcinog, Jan 2016
Moreover, the diet-derived cancer prevention agent, sulforaphane (SFN), suppresses MCS cell survival and this is associated with loss of Ezh2.
Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS.
Lomvardas et al., New York City, United States. In J Neurosci, Nov 2015
The objective of this review and the accompanying 2015 SfN mini-symposium is to highlight the use of new and emerging genomic technologies to probe enhancer function in the nervous system.
Epigenetic linkage of aging, cancer and nutrition.
Tollefsbol et al., Birmingham, United States. In J Exp Biol, 2015
Dietary compounds such as sulforaphane (SFN) found in cruciferous vegetables and epigallocatechin-3-gallate (EGCG) in green tea exhibit the ability to affect various epigenetic mechanisms such as DNA methyltransferase (DNMT) inhibition, histone modifications via histone deacetylase (HDAC), histone acetyltransferase (HAT) inhibition, or noncoding RNA expression.
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation.
Zheng et al., Changchun, China. In Oxid Med Cell Longev, 2014
Sulforaphane (SFN) is an ITC shown to possess anticancer activities by both in vivo and epidemiological studies.
The antioxidant properties of organosulfur compounds (sulforaphane).
Caligiorne et al., Ouro Preto, Brazil. In Recent Pat Endocr Metab Immune Drug Discov, 2014
Sulforaphane (SFN) is a molecule within the isothiocyanate (ITC) group of organosulfur compounds.
Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals.
González et al., Málaga, Spain. In Antioxidants (basel), 2014
The non-phenolic phytochemicals include carotenoids, caffeine and sulphoraphance (SFN).
SPARC/SFN interaction, suppresses type I collagen in dermal fibroblasts.
Ghahary et al., Vancouver, Canada. In J Cell Biochem, 2012
Data show that SFN and SPARC form a complex thereby controlling the type I collagen synthesis and expression in fibroblasts.
14-3-3σ expression is associated with poor pathological complete response to neoadjuvant chemotherapy in human breast cancers.
Noguchi et al., Suita, Japan. In Breast Cancer Res Treat, 2012
14-3-3sigma expression is significantly associated with resistance to paclitaxel followed by 5-FU, epirubicin and cyclophosphamide, and this association is independent of other biological markers
The cell cycle regulator protein 14-3-3σ is essential for hair follicle integrity and epidermal homeostasis.
Dixon et al., Manchester, United Kingdom. In J Invest Dermatol, 2012
We show that mice heterozygous for the 14-3-3sigma mutation have severe defects in hair shaft differentiation, resulting in destruction of the hair shaft during morphogenesis.
Silencing of CCDC6 reduces the expression of 14-3-3σ in colorectal carcinoma cells.
Anastasiadou et al., Athens, Greece. In Anticancer Res, 2012
down-regulation of 14-3-3sigma in the absence of CCDC6 demonstrated their direct association and supports the notion that CCDC6 contributes to cancer development, possibly through malignant pathways involving 14-3-3sigma
14-3-3σ regulation by p53 mediates a chemotherapy response to 5-fluorouracil in MCF-7 breast cancer cells via Akt inactivation.
He et al., Changsha, China. In Febs Lett, 2012
14-3-3sigma-mediated molecular events that synergise with p53 may play important roles in the chemotherapy of breast cancer.
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.
Dixon et al., Manchester, United Kingdom. In Nat Genet, 2006
We further demonstrate that mice that are compound heterozygotes for mutations in Irf6 and the gene encoding the cell cycle regulator protein stratifin (Sfn; also known as 14-3-3sigma) show similar defects of keratinizing epithelia.
A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice.
Siracusa et al., Albany, United States. In Nat Genet, 2005
mutation in stratifin is responsible for the repeated epilation phenotype
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.
Vogelstein et al., Baltimore, United States. In Nature, 1999
14-3-3Sigma is a member of a family of proteins that regulate cellular activity by binding and sequestering phosphorylated proteins.
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