TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils.
Paris, France. In J Leukoc Biol, Jun 2015
Moreover, CL075, but not loxoribine, induced the activation of the proline isomerase Pin1, and juglone, a Pin1 inhibitor, prevented CL075-mediated priming of fMLF-induced superoxide production.
Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α.
Madison, United States. In J Biol Chem, Jun 2015
The transcriptional activity of estrogen receptor α (ERα), the key driver of breast cancer proliferation, is enhanced by multiple cellular interactions, including phosphorylation-dependent interaction with Pin1, a proline isomerase, which mediates cis-trans isomerization of the N-terminal Ser(P)(118)-Pro(119) in the intrinsically disordered AF1 (activation function 1) domain of ERα.
Pathogenicity of Legionella pneumophila.
Chicago, United States. In Int J Med Microbiol, 2001
Surface structures that enhance infection include LPS, flagella, type IV pili, an outer membrane porin, and the Mip propyl-proline isomerase.
Potential double-flipping mechanism by E. coli MutY.
Galveston, United States. In Prog Nucleic Acid Res Mol Biol, 2000
However, following limited proteolytic digestion, it was revealed that the MutY protein is composed of two modules, a 26-kDa domain that retains essential catalytic function (designated p26MutY) and a 13-kDa domain that is implicated in substrate specificity and catalytic efficiency.