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FK506 binding protein 2, 13kDa

13-kDa, FKBP13, proline isomerase, FKBP2
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, SDSL
Papers on 13-kDa
ER trapping reveals Golgi enzymes continually revisit the ER through a recycling pathway that controls Golgi organization.
Lippincott-Schwartz et al., Bethesda, United States. In Proc Natl Acad Sci U S A, Jan 2016
Here, we demonstrate that the previously reported inefficient ER trapping of Golgi enzymes in a rapamycin-based assay results from an artifact involving an endogenous ER-localized 13-kD FK506 binding protein (FKBP13) competing with the FKBP12-tagged Golgi enzyme for binding to an FKBP-rapamycin binding domain (FRB)-tagged ER trap.
Unifying bacteria from decaying wood with various ubiquitous Gibbsiella species as G. acetica sp. nov. based on nucleotide sequence similarities and their acetic acid secretion.
Spiteller et al., Germany. In Microbiol Res, Dec 2015
Gibbsiella-specific PCR primers were designed from the proline isomerase and the levansucrase genes.
Cystatin C: why clinical laboratories should be measuring it.
Lamb, Canterbury, United Kingdom. In Ann Clin Biochem, Nov 2015
Cystatin C is a 13-kDa cysteine protease inhibitor that satisfies many of the criteria required of a marker of glomerular filtration rate.
TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils.
El-Benna et al., Paris, France. In J Leukoc Biol, Jun 2015
Moreover, CL075, but not loxoribine, induced the activation of the proline isomerase Pin1, and juglone, a Pin1 inhibitor, prevented CL075-mediated priming of fMLF-induced superoxide production.
Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α.
Alarid et al., Madison, United States. In J Biol Chem, Jun 2015
The transcriptional activity of estrogen receptor α (ERα), the key driver of breast cancer proliferation, is enhanced by multiple cellular interactions, including phosphorylation-dependent interaction with Pin1, a proline isomerase, which mediates cis-trans isomerization of the N-terminal Ser(P)(118)-Pro(119) in the intrinsically disordered AF1 (activation function 1) domain of ERα.
[Usefulness of Presepsin Measurement: A New Biomarker for Sepsis].
Okamura, In Rinsho Byori, 2015
Presepsin is a 13-kDa glycoprotein that is a truncated N-terminal fragment of CD14.
The Rift Valley fever accessory proteins NSm and P78/NSm-GN are distinct determinants of virus propagation in vertebrate and invertebrate hosts.
Flamand et al., Paris, France. In Emerg Microbes Infect, 2014
We found that, in the absence of the second AUG codon used to express NSm, a 13-kDa protein corresponding to an N-terminally truncated form of NSm, named NSm', was synthesized from AUG 3. None of the individual accessory proteins had any significant impact on RVFV virulence in mice.
Hidden alternative structures of proline isomerase essential for catalysis.
Alber et al., Berkeley, United States. In Nature, 2010
Here we introduce dual strategies of ambient-temperature X-ray crystallographic data collection and automated electron-density sampling to structurally unravel interconverting substates of the human proline isomerase, cyclophilin A (CYPA, also known as PPIA).
Peptidyl-prolyl isomerase activity in chloroplast thylakoid lumen is a dispensable function of immunophilins in Arabidopsis thaliana.
Vener et al., Linköping, Sweden. In Plant Cell Physiol, 2009
AtFKBP13-lacking mutants showed a dramatic decrease in peptidyl-prolyl isomerase activity.
Immunophilin AtFKBP13 sustains all peptidyl-prolyl isomerase activity in the thylakoid lumen from Arabidopsis thaliana deficient in AtCYP20-2.
Vener et al., Linköping, Sweden. In Biochemistry, 2007
None of the immunophilins in the chloroplast thylakoid lumen of Arabidopsis except AtCYP20-2 and AtFKBP13 appear to possess prolyl isomerase activity toward peptide substrates.
Proline isomerization of histone H3 regulates lysine methylation and gene expression.
Kouzarides et al., Cambridge, United Kingdom. In Cell, 2006
We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 proline P30 and P38 in vitro.
The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity.
Amon et al., Cambridge, United States. In Cell, 2005
Impaired checkpoint function is observed both in cells lacking FPR3 and in cells treated with rapamycin, a small molecule inhibitor that binds to the proline isomerase (PPIase) domain of Fpr3.
Redox regulation in the chloroplast thylakoid lumen: a new frontier in photosynthesis research.
Luan et al., Berkeley, United States. In J Exp Bot, 2005
Recent research has uncovered a new paradigm in which an immunophilin, FKBP13, and potentially other enzymes of the chloroplast thylakoid lumen are oxidatively activated in the light (2SH-->S-S).
Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.
Vaughan et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2003
FKBP13 and FK506 have roles in vesicular trafficking, influencing ADP-ribosylation factor activity through their guanine nucleotide-exchange proteins
Sterol carrier protein-2: structure reveals function.
Schroeder et al., Louisville, United States. In Cell Mol Life Sci, 2002
Both proteins share identical cDNA and amino acid sequences for 13-kDa SCP-2 at their C-termini.
Pathogenicity of Legionella pneumophila.
Cianciotto, Chicago, United States. In Int J Med Microbiol, 2001
Surface structures that enhance infection include LPS, flagella, type IV pili, an outer membrane porin, and the Mip propyl-proline isomerase.
Potential double-flipping mechanism by E. coli MutY.
Lloyd et al., Galveston, United States. In Prog Nucleic Acid Res Mol Biol, 2000
However, following limited proteolytic digestion, it was revealed that the MutY protein is composed of two modules, a 26-kDa domain that retains essential catalytic function (designated p26MutY) and a 13-kDa domain that is implicated in substrate specificity and catalytic efficiency.
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein.
Marks et al., New York City, United States. In Cell, 1994
FK506-binding protein (FKBP12) was originally identified as the cytosolic receptor for the immunosuppressant drugs FK506 and rapamycin.
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