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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zyxin

Zyxin, ZYX, esp-2
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LIM, Ajuba, CAN, Actin, ACID
Papers on Zyxin
Growth control: re-examining Zyxin's role in the hippo pathway.
New
Harvey, Melbourne, Australia. In Curr Biol, Apr 2015
A new study examines the role of the Hippo pathway protein Zyxin and finds that it antagonises Expanded to modulate F-actin and organ size.
Zyxin antagonizes the FERM protein expanded to couple F-actin and Yorkie-dependent organ growth.
New
Tapon et al., London, United Kingdom. In Curr Biol, Apr 2015
The actin-associated LIM proteins Zyxin (Zyx) and Ajuba (Jub) have been linked to the control of tissue growth via regulation of Hpo signaling, but the study of Zyx has been hampered by a lack of genetic tools.
Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells.
New
Barcellos et al., Campinas, Brazil. In Biochim Biophys Acta, Feb 2015
Vasodilator-stimulated phosphoprotein (VASP) and Zyxin are interacting proteins involved in cellular adhesion and motility.
α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation.
Takenawa et al., Kōbe, Japan. In Plos One, 2014
Interestingly, zyxin (ZYX) assembly to focal adhesions was markedly decreased in ACTN4-expressing DLD-1 cells, while the recruitment of paxillin (PAX) occurred normally.
The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans.
Nonet et al., Saint Louis, United States. In Development, 2014
In cultured cells, zyxin is recruited to focal adhesions and stress fibers via C-terminal LIM domains and modulates cytoskeletal organization via the N-terminal domain.
The metastasis suppressor NME1 regulates expression of genes linked to metastasis and patient outcome in melanoma and breast carcinoma.
Kaetzel et al., Baltimore, United States. In Cancer Genomics Proteomics, 2014
Nine genes were identified (false discovery rate <0.1) that were regulated by NME1 in both the WM1158 and WRO82 cell lines, each possessing one or more such metastasis-relevant activities as stress fiber formation and focal adhesion (PPM1E, ZYX, PFN1), chemotaxis (CCR1) epithelial-mesenchymal signaling (WNT6), differentiation and morphogenesis (TBX4, ZFP36L2), and G protein modulation (GPR52 and PFN1).
Characterization and development of photoactivatable fluorescent proteins for single-molecule-based superresolution imaging.
Zhuang et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 2014
Here, we evaluated these properties for 12 commonly used PAFPs fused to both bacterial target proteins, H-NS, HU, and Tar, and mammalian target proteins, Zyxin and Vimentin.
Molecular mechanisms underlying the force-dependent regulation of actin-to-ECM linkage at the focal adhesions.
Review
Lim et al., Singapore, Singapore. In Prog Mol Biol Transl Sci, 2013
Zyxin-dependent actin polymerization and filamin-mediated actin bundling are seemingly involved in the force-dependent actin accumulation.
The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth.
Butt et al., München, Germany. In Biol Cell, 2013
Here, we explored the role of the Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) in ES.
Drosophila integrin adhesion complexes are essential for hemocyte migration in vivo.
Prag et al., Lisbon, Portugal. In Biol Open, 2013
We also present evidence for the importance of adhesion maturation-related proteins in hemocyte migration, namely Zyxin.
The cytoskeletal protein Zyxin inhibits Shh signaling during the CNS patterning in Xenopus laevis through interaction with the transcription factor Gli1.
Zaraisky et al., Moscow, Russia. In Dev Biol, 2013
Zyxin is a cytoskeletal protein that controls cell movements by regulating actin filaments assembly, but it can also modulate gene expression owing to its interactions with the proteins involved in signaling cascades.
Zyxin cooperates with PTOV1 to confer retinoic acid resistance by repressing RAR activity.
Um et al., Seoul, South Korea. In Cancer Lett, 2013
Here, we first identified Zyxin that cooperates with PTOV1 for the negative regulation of RA signaling.
α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation.
Longmore et al., Saint Louis, United States. In Exp Cell Res, 2013
Focal adhesions formed in the absence of α-actinins are delayed in their maturation, exhibit altered morphology, have decreased amounts of Zyxin and VASP, and reduced adhesiveness to extracellular matrix.
ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration.
Gieseler et al., Villeurbanne, France. In Mol Biol Cell, 2013
In vertebrates, zyxin is a LIM-domain protein belonging to a family composed of seven members.
LIM Protein Ajuba Participates in the Repression of the ATR-Mediated DNA Damage Response.
Loayza et al., New York City, United States. In Front Genet, 2012
Our previous work has implicated members of the Zyxin family of LIM proteins, namely TRIP6 and LPP, in the repression of the DNA damage response (DDR) at telomeres.
Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.
GeneRIF
Eickelberg et al., München, Germany. In J Biol Chem, 2012
Zyxin is a transforming growth factor-beta (TGF-beta)/Smad3 target gene that regulates lung cancer cell motility via integrin alpha5beta1.
Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators.
GeneRIF
Beckerle et al., Salt Lake City, United States. In Mol Biol Cell, 2012
a bipartite mechanism for stretch-induced actin remodeling involves mechanosensitive targeting of zyxin to actin stress fibers and localized recruitment of actin regulatory machinery
Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.
GeneRIF
Wirtz et al., Baltimore, United States. In Nat Commun, 2011
Zyxin phenotype is mediated by partners alpha-actinin and p130Cas and ensures that motile cells in a three-dimensional matrix explore the largest space possible in minimum time.
A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions.
GeneRIF
Hansen et al., Provo, United States. In Biochem Biophys Res Commun, 2011
Depletion of nectin-2 from L cells expressing E-cadherin results in a loss of zyxin localization to cell-cell contacts, demonstrating that the zyxin-nectin interaction plays a critical role in zyxin targeting to these sites.
The LIM domain of zyxin is sufficient for force-induced accumulation of zyxin during cell migration.
GeneRIF
Yamada et al., Davis, United States. In Biophys J, 2011
LIM domain of zyxin recruits zyxin to force-bearing sites at the leading edge of migrating cells
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