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ZW10 interactor

Zwint-1, ZWINT, SIP30, HZwint-1
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ZW10, HEC, Mis12, iMpact, Zwilch
Papers using Zwint-1 antibodies
Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint
Supplier
Chan Gordon et al., In The Journal of Cell Biology, 2006
... hZW10 and hZwint-1 cDNAs were amplified from a HeLa cDNA library (Clontech Laboratories, Inc.) using specific ...
Papers on Zwint-1
Gene and stress history interplay in emergence of PTSD-like features.
New
Jett et al., United States. In Behav Brain Res, Nov 2015
A group of genes (Bdnf, Ngf, Zwint, Cckbr, Slc6a4, Fkbp5) linked to PTSD and synaptic plasticity were significantly altered in C57BL/6j and BALB/cj Agg-E mice.
Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.
Su Oh et al., Suwŏn, South Korea. In Sci Rep, 2014
Here we found that Zwint-1 is required for homologous chromosome segregation during meiosis.
Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.
Nilsson et al., Copenhagen, Denmark. In Nat Commun, 2014
The kinetochore protein Zwint has been proposed to be the kinetochore receptor for RZZ, but here we show that Bub1 and not Zwint is required for RZZ recruitment.
A two-hybrid screen identifies an unconventional role for the intermediate filament peripherin in regulating the subcellular distribution of the SNAP25-interacting protein, SIP30.
Robertson et al., Montréal, Canada. In J Neurochem, 2014
We focused on the interaction of Per-61 and the constitutive isoform, Per-58, with SNAP25 interacting protein 30 (SIP30), a neuronal protein involved in SNAP receptor-dependent exocytosis.
COX-2 inhibitors arrest prostate cancer cell cycle progression by down-regulation of kinetochore/centromere proteins.
Yang et al., United States. In Prostate, 2014
Biochemical analysis showed that inhibition of COX-2 or suppression of COX-2 expression induced a dramatic down-regulation of key proteins in the kinetochore/centromere assembly, such as ZWINT, Cdc20, Ndc80, CENP-A, Bub1, and Plk1.
Next generation sequencing analysis of miRNAs: MiR-127-3p inhibits glioblastoma proliferation and activates TGF-β signaling by targeting SKI.
Lin et al., Hangzhou, China. In Omics, 2014
We showed that miR-127-3p targeted SKI (v-ski sarcoma viral oncogene homolog [avian]), RGMA (RGM domain family, member A), ZWINT (ZW10 interactor, kinetochore protein), SERPINB9 (serpin peptidase inhibitor, clade B [ovalbumin], member 9), and SFRP1 (secreted frizzled-related protein 1).
SIP30 is required for neuropathic pain-evoked aversion in rats.
Zhang et al., Shanghai, China. In J Neurosci, 2014
SIP30 (SNAP25 interacting protein of 30) is a SNAP25 interaction protein of 30 kDa that functions in neurotransmitter release.
TRIM proteins as trim tabs for the homoeostasis.
Horie-Inoue, Saitama, Japan. In J Biochem, 2013
A recent report by Inoue and his colleagues has revealed that Terf/TRIM17 stimulates the degradation of a kinetochore protein ZWINT and regulates the proliferation of breast cancer cells.
Beclin-1 is required for chromosome congression and proper outer kinetochore assembly.
Berlioz-Torrent et al., Paris, France. In Embo Rep, 2013
We show that Beclin-1 interacts directly with Zwint-1-a component of the KMN (KNL-1/Mis12/Ndc80) complex-which is essential for kinetochore-microtubule interactions.
Genome-wide profiling of the activity-dependent hippocampal transcriptome.
Kuhl et al., Hamburg, Germany. In Plos One, 2012
One example is Zwint.
Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
GeneRIF
Inoue et al., Saitama, Japan. In J Biochem, 2012
the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation
Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.
GeneRIF
Vaughan et al., United States. In Mol Biol Cell, 2011
These studies identify zwint-1 as a novel AurB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase
hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.
GeneRIF
Chan et al., Edmonton, Canada. In Biochem J, 2011
hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain
Clinical, pathological, proliferative and molecular responses associated with neoadjuvant aromatase inhibitor treatment in breast cancer.
Review
Miller, Edinburgh, United Kingdom. In J Steroid Biochem Mol Biol, 2010
In terms of molecular events, aromatase inhibitor treatment is associated with changes in expression of genes classically associated with oestrogen regulation (KIAA0101, ZWINT, IRS1 and TFF1) and cell cycle progression, most notably mitotic phase proteins (CDC2, CCNB1 and CKS2).
SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain.
GeneRIF
Jing et al., Shanghai, China. In J Biol Chem, 2009
there is an ERK-responsive region in the rat sip30 promoter. Activation of ERK promotes the recruitment of the transcription factor cyclic AMP-response element-binding protein to the sip30 gene promoter
Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.
GeneRIF
Chan et al., Edmonton, Canada. In J Cell Biol, 2008
Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest.
Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment.
Impact
Stukenberg et al., Charlottesville, United States. In Cell, 2007
We find that the centrosome protein, xCep57, localizes to kinetochores and interacts with the kinetochore proteins Zwint, Mis12, and CLIP-170.
A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.
Impact
Yanagida et al., Kyoto, Japan. In Nat Cell Biol, 2004
Nine polypeptides bind to human hMis12; two of these, HEC1 and Zwint-1, are authentic kinetochore proteins.
Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction.
Impact
Mitsudomi et al., Nagoya, Japan. In J Clin Oncol, 2004
Next, we tried to identify a smaller number of genes of particular predictive value, and eight genes (PTK7, CIT, SCNN1A, PGES, ERO1L, ZWINT, and two ESTs) were selected.
Evaluation of measures used to assess quality of life after stroke.
Review
Ford et al., Liverpool, United Kingdom. In Stroke, 2000
Although the Ferrans and Powers QOL Index-Stroke Version, Niemi QOL scale, SA-SIP30, and Sickness Impact Profile come closest to satisfying many of the criteria outlined in this article, the selection of any individual instrument depends on the specific goals and constraints of a particular study.
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