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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zwilch, kinetochore associated, homolog

Zwilch, hZwilch
Top mentioned proteins: ZW10, ROD, Mad2, Smad1, Adenylate Cyclase
Papers on Zwilch
KNL1-Bubs and RZZ Provide Two Separable Pathways for Checkpoint Activation at Human Kinetochores.
Millar et al., Coventry, United Kingdom. In Dev Cell, Jan 2016
We provide evidence that the Rod-ZW10-Zwilch (RZZ) complex is necessary to recruit Mad1:Mad2 to, and delay anaphase onset in response to, unattached kinetochores independently of the KBB pathway.
RZZ and Mad1 dynamics in Drosophila mitosis.
Karess et al., Paris, France. In Chromosome Res, Jun 2015
Among the factors regulating the levels of Mad1 at kinetochores is the Rod, Zw10, and Zwilch (RZZ) complex, which is required for Mad1 recruitment through a mechanism that remains unknown.
Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex.
Musacchio et al., Dortmund, Germany. In Acta Crystallogr Sect F Struct Biol Commun, Apr 2015
In metazoans, the three-subunit Rod-Zwilch-ZW10 (RZZ) complex is a crucial SAC component that interacts with additional SAC-activating and SAC-silencing components, including the Mad1-Mad2 complex and cytoplasmic dynein.
A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.
Karess et al., Paris, France. In J Cell Sci, Apr 2015
Proper kinetochore recruitment and regulation of dynein and the Mad1-Mad2 complex requires the Rod-Zw10-Zwilch (RZZ) complex.
Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.
Nilsson et al., Copenhagen, Denmark. In Nat Commun, 2014
Checkpoint signalling requires the kinetochore localization of the Mad1-Mad2 complex that in more complex eukaryotes depends on the Rod-Zwilch-ZW10 (RZZ) complex.
CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.
Stukenberg et al., Charlottesville, United States. In J Cell Biol, 2014
The RZZ (Rod, ZW10, and Zwilch) complex and Mad1 proteins tightly associate with kinetochores to generate the spindle checkpoint signal, but they are released when a kinetochore forms mature microtubule attachments.
microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells.
Alajez et al., Riyadh, Saudi Arabia. In Cell Death Dis, 2013
Integrated analysis of bioinformatics and global gene expression profiling in miR-320c overexpressing cells and during adipocytic differentiation of hMSC identified several biologically relevant gene targets for miR-320c including RUNX2, MIB1 (mindbomb E3 ubiquitin protein ligase 1), PAX6 (paired box 6), YWHAH and ZWILCH.
Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores.
Salmon et al., Chapel Hill, United States. In J Cell Biol, 2013
In this paper, we show that the Knl1-Zwint1 complex is required to recruit the Rod-Zwilch-Zw10 (RZZ) and Mad1-Mad2 complexes to the outer kinetochore.
The Drosophila RZZ complex - roles in membrane trafficking and cytokinesis.
Gatti et al., Roma, Italy. In J Cell Sci, 2012
The Zw10 protein, in the context of the conserved Rod-Zwilch-Zw10 (RZZ) complex, is a kinetochore component required for proper activity of the spindle assembly checkpoint in both Drosophila and mammals.
hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.
Chan et al., Edmonton, Canada. In Biochem J, 2011
hZw10, along with its partners Rod (Roughdeal) and hZwilch, form a complex which recruits dynein-dynactin and Mad1-Mad2 complexes to the kinetochore and are essential components of the mitotic checkpoint.
Spindly switch controls anaphase: spindly and RZZ functions in chromosome attachment and mitotic checkpoint control.
Geley et al., Innsbruck, Austria. In Cell Cycle, 2011
At kinetochores Spindly interacts with the RZZ (Rod/ZW10/Zwilch) complex and is required for the recruitment of cytoplasmic dynein to kinetochores.
Regulators of the cytoplasmic dynein motor.
Vale et al., Cambridge, United States. In Nat Rev Mol Cell Biol, 2009
The answer could lie in the several multifunctional adaptors, including dynactin, lissencephaly 1, nuclear distribution protein E (NUDE) and NUDE-like, Bicaudal D, Rod-ZW10-Zwilch and Spindly, that regulate dynein function and localization.
The RZZ complex and the spindle assembly checkpoint.
Liu et al., Lanzhou, China. In Cell Struct Funct, 2008
It can form the RZZ complex with Zw10 and Zwilch, which plays an important role in maintaining a functional spindle assembly checkpoint.
Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint.
Cenci et al., Lecce, Italy. In Nat Genet, 2008
As expected from SAC activation, the SAC proteins Zw10, Zwilch, BubR1 and Cenp-meta (Cenp-E) accumulated at the kinetochores of cav mutant cells.
Rod-Zw10-Zwilch: a key player in the spindle checkpoint.
Karess, Gif-sur-Yvette, France. In Trends Cell Biol, 2005
But three proteins with no yeast homologs--Rod, Zw10 and Zwilch--also play a crucial, but poorly understood, role in the metazoan spindle checkpoint.
Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.
Goldberg et al., Ithaca, United States. In Mol Biol Cell, 2003
Zwilch localizes to kinetochores and kinetochore microtubules in a manner identical to ZW10 and ROD.
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