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ZW10, kinetochore associated, homolog

ZW10, hZW10
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: ROD, Zwilch, dynactin, Zwint-1, Mad2
Papers on ZW10
Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore.
Earnshaw et al., Suita, Japan. In J Cell Biol, Jan 2016
Ndc80 associated with CENP-T interacts with a cohort of Rod, zw10, and zwilch (RZZ)-interacting proteins that includes Spindly, Mad1, and CENP-E.
KNL1-Bubs and RZZ Provide Two Separable Pathways for Checkpoint Activation at Human Kinetochores.
Millar et al., Coventry, United Kingdom. In Dev Cell, Jan 2016
We provide evidence that the Rod-ZW10-Zwilch (RZZ) complex is necessary to recruit Mad1:Mad2 to, and delay anaphase onset in response to, unattached kinetochores independently of the KBB pathway.
Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex.
Musacchio et al., Dortmund, Germany. In Acta Crystallogr Sect F Struct Biol Commun, Apr 2015
In metazoans, the three-subunit Rod-Zwilch-ZW10 (RZZ) complex is a crucial SAC component that interacts with additional SAC-activating and SAC-silencing components, including the Mad1-Mad2 complex and cytoplasmic dynein.
Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.
Nilsson et al., Copenhagen, Denmark. In Nat Commun, 2014
Checkpoint signalling requires the kinetochore localization of the Mad1-Mad2 complex that in more complex eukaryotes depends on the Rod-Zwilch-ZW10 (RZZ) complex.
A dynein independent role of Tctex-1 at the kinetochore.
Mao et al., New York City, United States. In Cell Cycle, 2014
The kinetochore localization of Tctex-1 is independent of the ZW10-dynein pathway, but requires the Ndc80 complex.
Distinct sets of Rab6 effectors contribute to ZW10--and COG-dependent Golgi homeostasis.
Storrie et al., Little Rock, United States. In Traffic, 2014
MyoIIA and Kif20A depletions were pathway selective and suppressed ZW10-dependent Golgi ribbon fragmentation/dispersal only whereas BicD depletion, like Rab6, suppressed both ZW10- and COG-dependent Golgi ribbon fragmentation.
CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.
Stukenberg et al., Charlottesville, United States. In J Cell Biol, 2014
The RZZ (Rod, ZW10, and Zwilch) complex and Mad1 proteins tightly associate with kinetochores to generate the spindle checkpoint signal, but they are released when a kinetochore forms mature microtubule attachments.
Moonlighting functions of the NRZ (mammalian Dsl1) complex.
Kimura et al., Hachiōji, Japan. In Front Cell Dev Biol, 2013
Its metazoan counterpart NRZ complex, which comprises NAG, RINT1, and ZW10, is also involved in Golgi-to-ER retrograde transport, but each component of the complex has diverse cellular functions including endosome-to-Golgi transport, cytokinesis, cell cycle checkpoint, autophagy, and mRNA decay.
hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.
Chan et al., Edmonton, Canada. In Biochem J, 2011
hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain
Spindly switch controls anaphase: spindly and RZZ functions in chromosome attachment and mitotic checkpoint control.
Geley et al., Innsbruck, Austria. In Cell Cycle, 2011
At kinetochores Spindly interacts with the RZZ (Rod/ZW10/Zwilch) complex and is required for the recruitment of cytoplasmic dynein to kinetochores.
Regulators of the cytoplasmic dynein motor.
Vale et al., Cambridge, United States. In Nat Rev Mol Cell Biol, 2009
The answer could lie in the several multifunctional adaptors, including dynactin, lissencephaly 1, nuclear distribution protein E (NUDE) and NUDE-like, Bicaudal D, Rod-ZW10-Zwilch and Spindly, that regulate dynein function and localization.
Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.
Tagaya et al., Hachiōji, Japan. In Mol Biol Cell, 2009
Results together suggest that NAG links between p31 and ZW10-RINT-1 and is involved in Golgi-to-ER transport.
N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.
Tagaya et al., Hachiōji, Japan. In Genes Cells, 2008
The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner.
Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint.
Cenci et al., Lecce, Italy. In Nat Genet, 2008
The SAC was partially overridden by mutations in zw10 (also known as mit(1)15) and bubR1, and also by mutations in mei-41, mus304, rad50, grp and tefu.
Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.
Chan et al., Edmonton, Canada. In J Cell Biol, 2008
Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest.
Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores.
Chan et al., Edmonton, Canada. In Curr Biol, 2008
Accumulation of ZW10 at tensionless kinetochores stems from a 4-fold reduction of kinetochore turnover rate and requires aurora B kinase activity.
ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?
Dujardin et al., New York City, United States. In Cell Cycle, 2006
ZW10 has roles in mitotic checkpoint control, dynein targeting and membrane trafficking with dynein [review]
The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions.
Karpen et al., Los Angeles, United States. In Nat Cell Biol, 2001
Deconvolution fluorescence microscopy showed that CID chromatin is physically separate from proteins involved in sister cohesion (MEI-S332), centric condensation (PROD), kinetochore function (ROD, ZW10 and BUB1) and heterochromatin structure (HP1).
Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.
Yen et al., Philadelphia, United States. In Nat Cell Biol, 2000
Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors.
The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants.
Rieder et al., Albany, United States. In Nat Cell Biol, 2000
Here we show that the rate of poleward chromosome motion in zw10-null mutants is greatly attenuated throughout the division process, and that chromosome disjunction at anaphase is highly asynchronous.
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