gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Zona pellucida binding protein 2

ZPBP2, ZPBPL
Top mentioned proteins: GSDML, AGE, fibrillin-1, Orosomucoid, CIs
Papers on ZPBP2
Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population.
New
Naumova et al., Montréal, Canada. In J Med Genet, Jan 2016
RESULTS: The local genotype influenced methylation levels of solute carrier family 22 (organic 3 cation/carnitine transporter) member 5 (SLC22A5), zona pellucida binding protein 2 (ZPBP2) and gasdermin A (GSDMA) promoter regions.
Optimizing a Male Reproductive Aging Mouse Model by d-Galactose Injection.
New
Lin et al., Taipei, Taiwan. In Int J Mol Sci, Dec 2015
The d-gal-injected groups exhibited RNA transcripts of nine spermatogenesis-related genes (Cycl2, Hk1, Pltp, Utp3, Cabyr, Zpbp2, Speer2, Csnka2ip and Katnb1) that were up- or down-regulated by at least two-fold compared to the control group.
Genetic Determinants of Enterovirus Infections: Polymorphisms in Type 1 Diabetes and Innate Immune Genes in the MIDIA Study.
New
Rønningen et al., Oslo, Norway. In Viral Immunol, Dec 2015
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
Genome-wide association studies (GWAS) and their importance in asthma.
New
Dávila et al., Salamanca, Spain. In Allergol Immunopathol (madr), Nov 2015
The first GWAS was published in 2007, and described a new locus associated to asthma in chromosome 17q12-q21, involving the ORMDL3, GSDMB and ZPBP2 genes (a description of the genes named in the manuscript are listed in Table 1).
Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis.
New
Chew et al., Singapore, Singapore. In J Allergy Clin Immunol, Nov 2015
The polymorphic effect of this locus is attributed to the linkage set tagged by rs8076131, which affects the expression of ORMDL3, protein phosphatase 1, regulatory inhibitor subunit 1B (PPP1R1B), zona pellucida binding protein 2 (ZPBP2), and gasdermin B (GSDMB) and is correlated with high IgE levels and eosinophil counts in subjects bearing the risk genotype.
Exome analysis of patients with concurrent pediatric inflammatory bowel disease and autoimmune disease.
New
Ennis et al., Southampton, United Kingdom. In Inflamm Bowel Dis, Jun 2015
Three of these genes were previously implicated in both asthma and IBD (ZPBP2 IL1R1, and IL18R1) and 3 in asthma only (PYHIN1, IL2RB, and GSTP1).
Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility.
Almer et al., Jönköping, Sweden. In Biomed Res Int, 2014
The susceptibility allele was also associated with the increased expression of GSDMA (P = 1.6 × 10(-4)) and LRRC3C (P = 7.8 × 10(-6)) in colon tissue from individuals without IBD and with the reduced expression of PGAP3 (IBD; P = 2.0 × 10(-3)) and ZPBP2 (Crohn's disease; P = 7.7 × 10(-4)) in noninflamed ileum.
Sex- and age-dependent DNA methylation at the 17q12-q21 locus associated with childhood asthma.
Laprise et al., Montréal, Canada. In Hum Genet, 2013
We identified a single regulatory region within the zona pellucida binding protein 2 (ZPBP2) gene, which showed statistically significant differences between males and females with respect to DNA methylation.
17q12-21 and asthma: interactions with early-life environmental exposures.
Simpson et al., Slavonski Brod, Croatia. In Ann Allergy Asthma Immunol, 2013
Fifty-one haplotype tagging single-nucleotide polymorphisms (SNPs) were genotyped (GSDMA, GSDMB, ORMDL3, IKZF3, ZPBP2, and TOP2).
Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population.
Liu et al., Jinan, China. In Scand J Rheumatol, 2012
Seven single nucleotide polymorphisms (SNPs: rs7216389, rs12603332, rs12936231, rs9303277, rs11557467, rs1007654, and rs17608925), which were selected from chromosome 17q21 containing the genes ORMDL3, GSDMB, ZPBP2, and IKZF3, were genotyped by the Taqman SNP genotyping assay.
Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines.
GeneRIF
Naumova et al., Montréal, Canada. In Hum Genet, 2012
allele-specific transcriptional regulation of genes in the asthma-associated chromosomal region 17q12-q21; rs4795397 influences activity of ZPBP2 promoter in an allele-dependent fashion and leads to nucleosome repositioning on the asthma-associated allele; methylation of exon 1 of ZPBP2 masks the genetic effect on ZPBP2 promoter; ORMDL3 promoter is unmethylated
17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom.
Simpson et al., Manchester, United Kingdom. In Ann Allergy Asthma Immunol, 2012
We conducted a comprehensive investigation of 28 common SNPs within 6 genes of interest (IKZF3, ZPBP2, ORMDL3, GSDMA, GSDMB, TOP2A).
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.
GeneRIF
GENLES Network et al., Oklahoma City, United States. In Am J Hum Genet, 2012
Four additional susceptibility loci (IRF8, TMEM39A, IKZF3, and ZPBP2) for systemic lupus erythematosus were robustly established a multiethnic population (European, African American, Asian, Hispanic, Gullah, and Amerindian).
Genome-wide association studies for discovery of genes involved in asthma.
Review
Sandford et al., Vancouver, Canada. In Respirology, 2011
The first GWAS for asthma discovered a novel associated locus on chromosome 17q21 encompassing the genes ORMDL3, GSDMB and ZPBP2.
Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population.
Liu et al., Jinan, China. In Bmc Med Genet, 2010
In this study, we aimed to evaluate the association of polymorphisms in ORMDL3, GSDMB, ZPBP2 and IKZF3 and adult-onset asthma in a Chinese Han population.
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.
GeneRIF
Naumova et al., Québec, Canada. In Am J Hum Genet, 2009
The disease-linked haplotype and putative causal DNA variants of ZPBP2/GSDMB/ORMDL3 locus via a combination of genetic and functional analyses, were identified.
Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis.
GeneRIF
Matzuk et al., Houston, United States. In Mol Cell Biol, 2007
Data show that loss of zona pellucida binding proteins 1 and 2 in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis.
share on facebooktweetadd +1mail to friends