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Zona pellucida glycoprotein 2

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ZP1, ACID, CD45, Shh, CAN
Papers on ZP2
Developmental competence of different quality bovine oocytes retrieved through ovum pick-up following in vitro maturation and fertilization.
Chauhan et al., Karnāl, India. In Animal, Dec 2015
To analyze whether the developmental potential of the COCs bears a relation to morphological appearance, relative expression of a panel of genes associated with; (a) cumulus-oocyte interaction (Cx43, Cx37, GDF9 and BMP15), (b) fertilization (ZP2 and ZP3), (c) embryonic development (HSF1, ZAR1 and bFGF) and (d) apoptosis and survival (BAX, BID and BCL-XL, MCL-1, respectively) was studied at two stages: germinal vesicle (GV) stage and after in vitro maturation.
Bone morphogenetic protein 4 (BMP4) induces buffalo (Bubalus bubalis) embryonic stem cell differentiation into germ cells.
Chauhan et al., Karnāl, India. In Biochimie, Dec 2015
qPCR analysis revealed that BMP4 at a concentration of 50-100 ngml(-1) for a culture period of 14 days led to maximum induction of germ lineage genes like DAZL, VASA, PLZF (PGC-specific); SYCP3, MLH1, TNP1/2 and PRM2 (Meiotic genes); BOULE and TEKT1 (Spermatocyte markers); GDF9, ZP2 and 3 (Oocyte markers).
Identification of conserved hepatic transcriptomic responses to 17β-estradiol using high-throughput sequencing in brown trout.
Santos et al., Exeter, United Kingdom. In Physiol Genomics, Sep 2015
Using real-time quantitative PCR, we validated the expression of eight target genes and identified significant differences in the regulation of several known estrogen-responsive transcripts in fish exposed to the lower treatment concentrations (including esr1 and zp2.5).
Role of zona pellucida glycoproteins during fertilization in humans.
Gupta, New Delhi, India. In J Reprod Immunol, Apr 2015
The proposed model in mice of ZP glycoprotein-3 (ZP3) acting as primary sperm receptor and ZP glycoprotein-2 (ZP2) as secondary sperm receptor has been modified for sperm-egg binding in humans.
Moonlighting proteins in sperm-egg interactions.
Auer et al., In Biochem Soc Trans, 2014
We aimed to determine which sperm head proteins interact with ZP2, ZP3 and ZP4 in humans.
Melamine Impairs Female Fertility via Suppressing Protein Level of Juno in Mouse Eggs.
Xiong et al., Nanjing, China. In Plos One, 2014
To further figure out the cause, we analyzed ovastacin localization and protein level, the sperm binding ability of zona pellucida, and ZP2 cleavage status in unfertilized eggs from melamine fed mice, and no obvious differences were found between control and treatment groups.
The Hinge Region of Bovine Zona Pellucida Glycoprotein ZP3 Is Involved in the Formation of the Sperm-Binding Active ZP3/ZP4 Complex.
Yonezawa et al., Chiba, Japan. In Biomolecules, 2014
Bovine ZP consists of glycoproteins ZP2, ZP3, and ZP4.
[The function of transcription factor P63 and its signaling pathway during limb development].
Tian et al., Beijing, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2014
In brief, three signaling pathways are related to the digit formation along three axes, including SHH-ZPA, FGFs-AER and Lmx1B-Wnt7a-En1.
Mutant ZP1 in familial infertility.
Xiao et al., Xiamen, China. In N Engl J Med, 2014
The human zona pellucida is composed of four glycoproteins (ZP1, ZP2, ZP3, and ZP4) and has an important role in reproduction.
Posttranslational modifications of zona pellucida proteins.
Yonezawa, Chiba, Japan. In Adv Exp Med Biol, 2013
One ZP protein, ZP2, is processed at a specific site upon fertilization by ovastacin, which is released from cortical granules inside the oocyte.
Digit loss in archosaur evolution and the interplay between selection and constraints.
Richardson et al., Leiden, Netherlands. In Nature, 2013
We suggest that the persistence of digit V in the embryo may reflect constraints, particularly the conserved posterior gene networks associated with the zone of polarizing activity (ZPA).
The molecular basis of gamete recognition in mice and humans.
Dean et al., Bethesda, United States. In Mol Hum Reprod, 2013
More recently, taking advantage of the observation that human sperm do not bind to mouse eggs, human ZP2 was defined as the zona ligand in transgenic mouse models using gain-of-function assays.
Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.
Dean et al., Bethesda, United States. In J Cell Biol, 2012
Recombinant ovastacin cleaved ZP2 in native zonae pellucidae, documenting that ZP2 was a direct substrate of this metalloendoprotease.
ZP2 and ZP3 cytoplasmic tails prevent premature interactions and ensure incorporation into the zona pellucida.
Dean et al., Bethesda, United States. In J Cell Sci, 2011
Cytoplasmic tails are necessary to prevent intracellular oligomerization while ensuring incorporation of processed ZP2 and ZP3 into the zona pellucida.
Mouse granulosa cells contribute more to the mRNA synthesis of mZP2 than oocyte does.
Cao et al., Guangzhou, China. In Cell Biochem Funct, 2011
The granulosa cells contribute more to the mZP2 mRNA synthesis than oocyte does.
Evolutionary patterns of two major reproduction candidate genes (Zp2 and Zp3) reveal no contribution to reproductive isolation between bovine species.
Beja-Pereira et al., Porto, Portugal. In Bmc Evol Biol, 2010
Polymorphism of Zp2 and the Zp3 did not show any contribution to reproductive isolation between the bovine species.
Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein.
Dean et al., Bethesda, United States. In Science, 2010
data indicate that sperm-egg recognition depends on the cleavage status of ZP2 and that binding at the surface of the zona is not sufficient to induce sperm acrosome exocytosis
Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats.
Jovine et al., Huddinge, Sweden. In Nature, 2009
Zona pellucida filament components ZP3 and ZP2 act as sperm receptors, and mice lacking either of the corresponding genes produce oocytes without a zona pellucida and are completely infertile.
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.
Tabin et al., Gainesville, United States. In Cell, 2004
The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog (Shh) protein, which plays a critical role in establishing distinct fates along the anterior-posterior axis.
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