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Zona pellucida glycoprotein 4

ZP1, ZPB, ZP4, mZP1
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ZP2, CD45, ACID, CAN, HAD
Papers on ZP1
Ovarian function and pregnancy outcome in pony mares following immunocontraception with native and recombinant porcine zona pellucida vaccines.
New
Schulman et al., Pretoria, South Africa. In Equine Vet J, Jan 2016
OBJECTIVES: This study aimed to describe ovarian function and oestrous cyclicity in pony mares following treatment with either the conventional pZP vaccine or a novel recombinant form of the vaccine derived from porcine ZP3 and ZP4 (reZP).
Bone morphogenetic protein 4 (BMP4) induces buffalo (Bubalus bubalis) embryonic stem cell differentiation into germ cells.
New
Chauhan et al., Karnāl, India. In Biochimie, Dec 2015
Immunocytochemical analysis of embryoid bodies (EBs) and monolayer adherent cultures revealed expression of PGC- (c-KIT, DAZL and VASA); Meiotic- (SYCP3, MLH1 and PROTAMINE1); Spermatocyte- (ACROSIN and HAPRIN); and Oocyte- markers (GDF9 and ZP4).
Sturgeon hatching enzyme and the mechanism of egg envelope digestion: Insight into changes in the mechanism of egg envelope digestion during the evolution of ray-finned fish.
New
Yasumasu et al., Tokyo, Japan. In J Exp Zool B Mol Dev Evol, Dec 2015
Teleostei hatching enzymes cleave the repeat sequences at the N-terminal region of ZPB and ZPC, suggesting that the targets of the teleostei hatching enzymes differ from those of amphibians and sturgeons.
Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.
New
Chauhan et al., In Reprod Fertil Dev, Dec 2015
Immunocytochemical analysis revealed expression of primordial germ cell (c-KIT, DAZL and VASA), meiotic (SYCP3, MLH1 and PROTAMINE 1), spermatocyte (ACROSIN and HAPRIN) and oocyte (GDF9 and ZP4) markers in both EBs and monolayer differentiation cultures.
Role of zona pellucida glycoproteins during fertilization in humans.
Review
New
Gupta, New Delhi, India. In J Reprod Immunol, Apr 2015
ZP glycoprotein-1 (ZP1), ZP3, and ZP glycoprotein-4 (ZP4) have been shown to bind to the capacitated human sperm.
Human sperm degradation of zona pellucida proteins contributes to fertilization.
Chirinos et al., Mexico. In Reprod Biol Endocrinol, 2014
CONCLUSIONS: This study suggests that sperm proteasomes could participate in the degradation of ZP, particularly of the ZP4 protein.
Moonlighting proteins in sperm-egg interactions.
Review
Auer et al., In Biochem Soc Trans, 2014
We aimed to determine which sperm head proteins interact with ZP2, ZP3 and ZP4 in humans.
The Hinge Region of Bovine Zona Pellucida Glycoprotein ZP3 Is Involved in the Formation of the Sperm-Binding Active ZP3/ZP4 Complex.
Yonezawa et al., Chiba, Japan. In Biomolecules, 2014
Bovine ZP consists of glycoproteins ZP2, ZP3, and ZP4.
Mutant ZP1 in familial infertility.
Impact
Xiao et al., Xiamen, China. In N Engl J Med, 2014
The human zona pellucida is composed of four glycoproteins (ZP1, ZP2, ZP3, and ZP4) and has an important role in reproduction.
In silico identification of the genes for sperm-egg interaction in the internal fertilization of the newt Cynops pyrrhogaster.
Takayama-Watanabe et al., Yamagata, Japan. In Int J Dev Biol, 2013
In the ovary, ZP homologues of all six subgroups were found, including a ZP1 homologue that was newly found in amphibians, a ZP4 homologue, and six ZPC homologues.
The molecular basis of gamete recognition in mice and humans.
Review
Dean et al., Bethesda, United States. In Mol Hum Reprod, 2013
The ZP of humans is composed of four (ZP1-4) and that of mouse three (ZP1-3) glycoproteins.
Biogenesis of the mouse egg's extracellular coat, the zona pellucida.
Review
Litscher et al., New York City, United States. In Curr Top Dev Biol, 2012
The mouse egg's ZP consists of only three glycoproteins, called ZP1-3, that are synthesized, secreted, and assembled into an extracellular coat exclusively by growing oocytes during late stages of oogenesis while oocytes are arrested in meiosis.
Influence of the zona pellucida of the mouse egg on folliculogenesis and fertility.
Review
Litscher et al., New York City, United States. In Int J Dev Biol, 2011
The mouse egg ZP consists of three glycoproteins, called mZP1-3, that are synthesized solely by oocytes during their 2-to-3 week growth phase.
Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice.
GeneRIF
Dean et al., Bethesda, United States. In Reproduction, 2011
Human ZP4 is not sufficient to support human sperm binding to the zona pellucida in transgenic mice; other zona proteins may be needed for human gamete recognition.
Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein.
Impact
Dean et al., Bethesda, United States. In Science, 2010
At fertilization, mouse sperm bind to the zona pellucida (which consists of glycoproteins ZP1, ZP2, and ZP3) that surrounds eggs.
DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies.
GeneRIF
Gupta et al., New Delhi, India. In J Reprod Immunol, 2009
a significant decrease in acrosomal exocytosis mediated by both recombinant human ZP3 (p<0.005) and ZP4 (p<0.005) was observed in presence of the immune sera
Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa.
GeneRIF
Yeung et al., Hong Kong, Hong Kong. In Biol Reprod, 2008
induces acrosome reactions which are protein kinase-C, protein tyrosine kinase, T-type Ca2+ channels, and extracellular Ca2+ dependent
Biological effects of recombinant human zona pellucida proteins on sperm function.
GeneRIF
Gerton et al., Philadelphia, United States. In Biol Reprod, 2006
Exposure of sperm to ZP proteins promoted acrosomal exocytosis and changed motility patterns.
Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC.
GeneRIF
Vazquez-Levin et al., Buenos Aires, Argentina. In Fertil Steril, 2005
Binding sites for recombinant zona pellucida B (ZPB) glycoprotein are located both at the N- and C-terminus of proacrosin
Vaccination with a synthetic zona pellucida peptide produces long-term contraception in female mice.
Impact
Dean et al., Bethesda, United States. In Science, 1989
The zona pellucida surrounding mouse oocytes is an extracellular matrix composed of three sulfated glycoproteins, ZP1, ZP2, and ZP3.
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