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Tight junction protein 3

ZO-3
TJP3 is a member of the family of membrane-associated guanylate kinase-like proteins (MAGUK) that associate with intracellular junctions (Itoh et al., 1999 [PubMed 10601346]).[supplied by OMIM, Mar 2009] (from NCBI)
Top mentioned proteins: ZO-1, ZO-2, Occludin, cingulin, Actin
Papers on ZO-3
The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis.
New
Breton et al., In Biol Reprod, Jan 2016
Inhibition of mitogen activated protein kinase kinase (MAPKK or MEK1/2) with PD325901, followed by reduction of ERK1/2 phosphorylation (pERK), decreased zonula occludens (ZO)-2 expression and increased ZO-3 expression in TJs, but had no effect on ZO-1 expression.
ZO-1 and -2 Are Required for TRPV1-Modulated Paracellular Permeability.
New
Yu et al., Beijing, China. In J Dent Res, Dec 2015
TRPV1 activation obviously diminished ZO-1 and -2 staining, but not ZO-3 or β-catenin, at the cell-cell contacts ex vivo and in vitro.
L-Glutamate Enhances Barrier and Antioxidative Functions in Intestinal Porcine Epithelial Cells.
New
Wu et al., Beijing, China. In J Nutr, Oct 2015
In a cell model of oxidative stress induced by 1 mmol/L diquat, 0.5 mmol/L Glu enhanced cell viability, TEER, and membrane integrity (as indicated by the reduced release of LDH) in IPEC-1 cells by increasing the abundance of the tight junction proteins occludin, claudin-3, zonula occludens (ZO)-2, and ZO-3.
l-Tryptophan Activates Mammalian Target of Rapamycin and Enhances Expression of Tight Junction Proteins in Intestinal Porcine Epithelial Cells.
New
Wu et al., Beijing, China. In J Nutr, Jun 2015
L-Trp also upregulated (P < 0.05) the abundance of occludin, claudin-4, zonula occludens (ZO) 1 and 2 by 0.5-2 fold but did not affect expression of claudin-1 or ZO-3 in IPEC-1 cells.
Glutamine enhances tight junction protein expression and modulates corticotropin-releasing factor signaling in the jejunum of weanling piglets.
Wu et al., Beijing, China. In J Nutr, 2015
Western blot analysis showed reductions (P < 0.05) in jejunal expression of occludin, claudin-1, zonula occludens (ZO) 2, and ZO-3, but no changes in the abundance of claudin-3, claudin-4, or ZO-1 in weanling piglets compared with age-matched suckling controls.
The squid ink polysaccharides protect tight junctions and adherens junctions from chemotherapeutic injury in the small intestinal epithelium of mice.
Tang et al., Qingdao, China. In Nutr Cancer, 2014
OBP also remarkably enhanced the mRNA expression of other tight junction proteins, ZO-2, ZO-3, claudin-2, and cingulin.
Long-term oral melatonin administration reduces ethanol-induced increases in duodenal mucosal permeability and motility in rats.
Sjöblom et al., Uppsala, Sweden. In Acta Physiol (oxf), 2014
The expression levels of the tight junction components, zona occludens (ZO)-1, ZO-2, and ZO-3, claudin-2, claudin-3, claudin-4, occludin, and myosin light chain kinase and of the melatonin receptors MT1 and MT2 were assessed using qRT-PCR.
ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
Citi et al., Genève, Switzerland. In J Biol Chem, 2014
To address this discrepancy, we examined the localization and activity of DbpA and YAP in Madin-Darby canine kidney cells depleted either of ZO-1, or one of the related proteins ZO-2 and ZO-3 (ZO proteins), or all three together.
Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion.
Hasler et al., Genève, Switzerland. In Cell Cycle, 2013
Contrary to ZO-1 and ZO-2, ZO-3 expression at intercellular junctions dramatically increased with cell density and relied on the presence of ZO-1.
ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape.
Furuse et al., Kōbe, Japan. In Plos One, 2013
ZO-1, ZO-2 and ZO-3 are tight junction-associated scaffold proteins that bind to transmembrane proteins of tight junctions and the underlying cytoskeleton.
Beyond cell-cell adhesion: Emerging roles of the tight junction scaffold ZO-2.
Review
Bauer et al., Salzburg, Austria. In Tissue Barriers, 2013
Zonula occludens proteins (ZO-1, ZO-2, ZO-3), which belong to the family of membrane-associated guanylate kinase (MAGUK) homologs, serve as molecular hubs for the assembly of multi-protein networks at the cytoplasmic surface of intercellular contacts in epithelial and endothelial cells.
Tight junctions in lung cancer and lung metastasis: a review.
Review
Soini, Kuopio, Finland. In Int J Clin Exp Pathol, 2011
These molecules are attached to scaffolding proteins such as ZO-1, ZO-2 and ZO-3 through which signals are mediated to the cell interior.
ZO proteins and redox-dependent processes.
Review
Díaz-Coránguez et al., Mexico. In Antioxid Redox Signal, 2011
SIGNIFICANCE: ZO-1, ZO-2, and ZO-3 are scaffold proteins of the tight junction (TJ) that belong to the MAGUK protein family characterized for exhibiting PDZ, SH3, and GuK domains.
Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation.
GeneRIF
Nusrat et al., Atlanta, United States. In Mol Biol Cell, 2011
Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation
Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function.
GeneRIF
Tsukita et al., Suita, Japan. In Ann N Y Acad Sci, 2009
ZO-3 shows an epithelial-specific Tight junctions localization
Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.
GeneRIF
Hunziker et al., Singapore, Singapore. In Mol Cell Biol, 2008
Early embryonic lethality of mice lacking Tjp2, but not Tjp3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.
[Advances in study of novel absorption enhancers based on tight junctions].
Review
Wang et al., Nanjing, China. In Yao Xue Xue Bao, 2007
Tight junction proteins are identified including transmembrane proteins (occludin, claudin and JAM) , cytoplasmic plaque proteins (ZO-1, ZO-2, ZO-3 and cingulin) and cytoskeleton.
Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein.
GeneRIF
Tsukita et al., Kyoto, Japan. In Mol Cell Biol, 2006
ZO-3 (-/-) mice were viable and fertile and their tight junctions did not appear to be affected.
Tight junction modulation and its relationship to drug delivery.
Review
Fasano et al., Baltimore, United States. In Adv Drug Deliv Rev, 2006
TJ proteins identified include transmembrane proteins; occludin and claudin, and cytoplasmic plaque proteins; ZO-1, ZO-2, ZO-3, cingulin, and 7H6.
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