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Tight junction protein 2

ZO-2
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: ZO-1, Occludin, Actin, ZO-3, claudin-1
Papers on ZO-2
Ex vivo construction of a novel model of bioengineered bladder mucosa: A preliminary study.
New
Garzón et al., Granada, Spain. In Int J Urol, Jan 2016
After 7 days of ex vivo development, the epithelial layer expressed pancytokeratin, and cytokeratins CK7, CK8 and CK13, as well as filaggrin and ZO-2, with negative expression of CK4 and uroplakin III.
Ontogeny of tight junction protein expression in the ovine cerebral cortex during development.
New
Stonestreet et al., Providence, United States. In Neuroscience, Jan 2016
We have previously shown that claudin-1, claudin-5, zonula occludens (ZO)-1, and ZO-2 exhibit differential developmental regulation from 60% of gestation up to maturity in adult sheep.
Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1.
New
Zhang et al., Richmond, United States. In J Cell Mol Med, Dec 2015
Our findings demonstrate that the activation of Nlrp3 inflammasome by visfatin markedly decreased the expression of inter-endothelial junction proteins including tight junction proteins ZO-1, ZO-2 and occludin, and adherens junction protein VE-cadherin in cultured mouse vascular endothelial (VE) cell monolayers.
Three-dimensional co-culture of BM-MSCs and eccrine sweat gland cells in Matrigel promotes transdifferentiation of BM-MSCs.
New
Fu et al., Shantou, China. In J Mol Histol, Oct 2015
We co-cultured BrdU-labeled bone marrow-derived mesenchymal stem cells (BM-MSCs) and eccrine sweat gland cells in Matrigel for 2 weeks in vitro and then evaluated for BM-MSCs differentiation into functional eccrine sweat gland cells by morphological assessment and immunohistochemical double staining for BrdU/pancytokeratin, BrdU/ZO-2, BrdU/E-cadherin, BrdU/desmoglein-2, BrdU/Na(+)-K(+)-ATPase α, BrdU/NHE1 and BrdU/CFTR.
Mutations in TJP2, encoding zona occludens 2, and liver disease.
New
Thompson et al., London, United Kingdom. In Tissue Barriers, Jul 2015
The latest addition to this family of diseases is tight junction protein 2 (TJP2) deficiency.
NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation.
Koval et al., Atlanta, United States. In Tissue Barriers, 2014
However, there was little effect on the total amount of cell-associated claudin-7, occludin, junctional adhesion molecule A (JAM-A), zonula occludens (ZO)-1 or ZO-2.
Heme oxygenase-1 protects corexit 9500A-induced respiratory epithelial injury across species.
Antony et al., Birmingham, United States. In Plos One, 2014
The expression of the intercellular junctional proteins, such as tight junction proteins occludin, zonula occludens (ZO-1), ZO-2 and adherens junctional proteins E-cadherin and Focal Adhesion Kinase (FAK), were remarkably inhibited by CE, suggesting that these proteins are involved in CE-induced increased permeability and subsequent apoptosis.
Effects of hydrogen sulfide on high glucose-induced glomerular podocyte injury in mice.
Fu et al., Jinan, China. In Int J Clin Exp Pathol, 2014
Then, ZO-2, nephrin, β-catenin, and cystathionine γ-lyase (CSE) protein expression levels were determined by western blot.
Beyond cell-cell adhesion: Emerging roles of the tight junction scaffold ZO-2.
Review
Bauer et al., Salzburg, Austria. In Tissue Barriers, 2013
Zonula occludens proteins (ZO-1, ZO-2, ZO-3), which belong to the family of membrane-associated guanylate kinase (MAGUK) homologs, serve as molecular hubs for the assembly of multi-protein networks at the cytoplasmic surface of intercellular contacts in epithelial and endothelial cells.
Barriers and more: functions of tight junction proteins in the skin.
Review
Brandner et al., Hamburg, Germany. In Ann N Y Acad Sci, 2012
Although the existence of tight junction (TJ) structures (or a secondary epidermal barrier) was postulated for a long time, the first description of TJ proteins in the epidermis (occludin, ZO-1, and ZO-2) was only fairly recent.
ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis.
Review
GeneRIF
Quiros et al., Mexico. In Ann N Y Acad Sci, 2012
ZO-2 inhibits the Wnt signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.
Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP.
GeneRIF
Sudol et al., United States. In Oncogene, 2012
AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP.
Tight junctions in lung cancer and lung metastasis: a review.
Review
Soini, Kuopio, Finland. In Int J Clin Exp Pathol, 2011
These molecules are attached to scaffolding proteins such as ZO-1, ZO-2 and ZO-3 through which signals are mediated to the cell interior.
ZO proteins and redox-dependent processes.
Review
Díaz-Coránguez et al., Mexico. In Antioxid Redox Signal, 2011
SIGNIFICANCE: ZO-1, ZO-2, and ZO-3 are scaffold proteins of the tight junction (TJ) that belong to the MAGUK protein family characterized for exhibiting PDZ, SH3, and GuK domains.
The tight junction protein ZO-2 and Janus kinase 1 mediate intercellular communications in vascular smooth muscle cells.
GeneRIF
Dumler et al., Hannover, Germany. In Biochem Biophys Res Commun, 2011
these findings imply involvement of the ZO-2 tight junction independent signaling complex containing Jak1 and uPAR in VSMC intercellular communications.
Assessments of tight junction proteins occludin, claudin 5 and scaffold proteins ZO1 and ZO2 in endothelial cells of the rat blood-brain barrier: cellular responses to neurotoxicants malathion and lead acetate.
GeneRIF
Ehrich et al., Blacksburg, United States. In Neurotoxicology, 2011
Levels of tight junction protein ZO2 are decreased in blood brain barrier cells post-translationally following neurotoxicant administration.
Identification of ZASP, a novel protein associated to Zona occludens-2.
GeneRIF
González-Mariscal et al., Mexico. In Exp Cell Res, 2010
The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds.
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.
Impact
GeneRIF
Tsukita et al., Kyoto, Japan. In Cell, 2006
These findings indicate that ZO-1 and ZO-2 can independently determine whether and where claudins are polymerized.
Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT.
Impact
GeneRIF
Bull et al., San Francisco, United States. In Nat Genet, 2003
Familial hypercholanemia in Amish individuals is associated with mutations in tight junction protein 2 (encoded by TJP2, also known as ZO-2) and bile acid Coenzyme A: amino acid N-acyltransferase (encoded by BAAT).
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