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Zinc finger protein 750

This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: KLF4, CHIP, p63, PI3K, CAN
Papers on ZNF750
Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain.
Ma et al., Beijing, China. In Mol Psychiatry, Feb 2016
Logistic regression identified significant interaction between rs3744165 (5'-untranslated region variant of exon 2 of zinc finger protein 750 (ZNF750), and in an intron of TBCD) and rs8073471 (Deviance test P-value=2.77
Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR.
Khavari et al., Stanford, United States. In Dev Cell, Dec 2015
MPZL3 was essential for normal differentiation, acting downstream of p63, ZNF750, KLF4, and RCOR1, each of which bound near the MPZL3 gene and controlled its expression.
CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.
Khavari et al., Stanford, United States. In Genes Dev, Dec 2015
CALML5 mRNA was up-regulated by the ZNF750 transcription factor and then stabilized by the long noncoding RNA TINCR.
Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.
Cui et al., Taiyuan, China. In Am J Hum Genet, May 2015
In our combined cohort, we identified frequent inactivating mutations in AJUBA, ZNF750, and PTCH1 and the chromatin-remodeling genes CREBBP and BAP1, in addition to known mutations.
A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation.
Khavari et al., Stanford, United States. In Dev Cell, Apr 2015
ChIP-seq analysis demonstrated MAF:MAFB binding to known epidermal differentiation TF genes whose expression they controlled, including GRHL3, ZNF750, KLF4, and PRDM1.
ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes.
Khavari et al., Stanford, United States. In Genes Dev, 2014
ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing differentiation genes, a role underscored by pathogenic ZNF750 mutations in cancer and psoriasis.
Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.
Elder et al., Nashville, United States. In J Invest Dermatol, 2014
Weighted gene coexpression network analysis (WGCNA) revealed multiple modules of coordinately expressed epidermal differentiation genes, overlapping significantly with genes regulated by the long noncoding RNA TINCR, its target gene, staufen-1 (STAU1), the p63 target gene ZNF750, and its target KLF4.
Genomic and molecular characterization of esophageal squamous cell carcinoma.
Koeffler et al., Los Angeles, United States. In Nat Genet, 2014
We identified previously uncharacterized mutated genes such as FAT1, FAT2, ZNF750 and KMT2D, in addition to those already known (TP53, PIK3CA and NOTCH1).
Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk.
Maleszka et al., Szczecin, Poland. In Arch Dermatol Res, 2014
We assessed the association of psoriasis and its main clinical phenotypes with common variants of three potential psoriasis susceptibility genes: ZNF750, RPTOR and TRAF31P2.
Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63.
Khavari et al., Stanford, United States. In Am J Hum Genet, 2012
Human epidermis harboring AEC TP63 mutants recapitulated this impairment, along with downregulation of differentiation activators, including HOPX, GRHL3, KLF4, PRDM1, and ZNF750.
ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation.
Khavari et al., San Diego, United States. In Dev Cell, 2012
ZNF750 directly links a tissue-specifying factor, p63, to an effector of terminal differentiation, KLF4.
ZNF750 is expressed in differentiated keratinocytes and regulates epidermal late differentiation genes.
Birk et al., Beersheba, Israel. In Plos One, 2011
We have previously demonstrated that a dominant mutation in ZNF750 leads to a clinical phenotype reminiscent of psoriasis and seborrheic dermatitis.
Association analysis identifies ZNF750 regulatory variants in psoriasis.
Liao et al., San Francisco, United States. In Bmc Med Genet, 2010
Two haplotypes of ZNF750 and rare 5' regulatory variants of ZNF750 were found to be associated with psoriasis.
A promoter sequence variant of ZNF750 is linked with familial psoriasis.
Chen et al., Taipei, Taiwan. In J Invest Dermatol, 2008
ZNF750 mutations could contribute to psoriasis susceptibility.
Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein.
Birk et al., Beersheba, Israel. In Nat Genet, 2006
We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein.
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