Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells—Probe 2
Bethesda, United States. In Unknown Journal, 2011
Gene expression profiling revealed that ML245 regulated the expression of several pro-apoptotic/mitochondrial maintenance factors (such as caspase recruitment domain family member 10, activating transcription factor 4, mitochondrial ribosomal protein MRPL12), and DNA-modifying enzymes (such as Early Growth Response 1, zinc finger-containing proteins ZNF295 and CGRRF1, and TBP-associated factor 1D), in the CSC-like cell line and not the isogenic control cell line.
Upregulation of beta-catenin expression in down syndrome model Ts65Dn mouse brain.
New York City, United States. In Neuroscience, 2009
Using a mouse model of DS, the Ts65Dn mouse, we have performed mRNA and protein measurements to identify genes on chromosomes not syntenic with Hsa 21 whose expression is affected by the presence of three copies of genes between loci Mrpl39 and Znf295 on mouse chromosome 16 (Mmu 16).
Evolutionary breakpoints on human chromosome 21.
Bar Harbor, United States. In Genomics, 2001
The mouse chromosome 16/chromosome 17 evolutionary breakpoint is between human genes ZNF295 and UMODL1, showing there are seven genes in the chromosome 16 segment distal to Tmprss2.