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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

N-acylsphingosine amidohydrolase 2

znCD, neutral ceramidase
Top mentioned proteins: ACID, V1a, HAD, fibrillin-1, CAN
Papers on znCD
Loss of neutral ceramidase protects cells from nutrient and energy deprivation-induced cell death.
Siskind et al., Stony Brook, United States. In Biochem J, Feb 2016
Cells lacking neutral ceramidase (nCDase(-/-)) were protected from 2DG/AA.
Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate.
Lentsch et al., Cincinnati, United States. In J Hepatol, Jan 2016
Mechanistically, hepatocyte exosomes directly fuse with target hepatocytes and transfer neutral ceramidase and sphingosine kinase 2 (SK2) causing increased synthesis of sphingosine-1-phosphate (S1P) within target hepatocytes.
Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.
Fabrias et al., Barcelona, Spain. In J Lipid Res, Oct 2015
Both bacterial and human purified neutral ceramidases (NCs), as well as ectopically expressed mouse neutral ceramidase hydrolyzed RBM14 with different selectivity, depending on the N-acyl chain length.
An Arabidopsis neutral ceramidase mutant ncer1 accumulates hydroxyceramides and is sensitive to oxidative stress.
Yao et al., Guangzhou, China. In Front Plant Sci, 2014
Here, we characterized the Arabidopsis thaliana ceramidase AtNCER1, a homolog of human neutral ceramidase.
Low-dose cytokine-induced neutral ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect.
He et al., Nanjing, China. In Febs J, 2014
We also found that cytokines at a low concentration stimulated neutral ceramidase (NCDase) release via exosomes from INS-1 cells, whereas cytokines at a high concentration inhibited NCDase release.
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Gudz et al., Charleston, United States. In J Biol Chem, 2014
Investigation of intracellular sites of sphingosine accumulation revealed an elevation of sphingosine in mitochondria due to the activation of neutral ceramidase (NCDase) and the reduced activity of sphingosine kinase 2 (SphK2).
New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase.
Tani et al., Fukuoka, Japan. In Biochim Biophys Acta, 2014
These enzymes are classified into three distinct groups, acid (Asah1), neutral (Asah2), and alkaline (Asah3) CDases, based on their primary structure and optimum pH.
Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.
Ma et al., Philadelphia, United States. In Circ Res, 2014
Treatment with adiponectin significantly increased neutral ceramidase (nCDase) activity (3.7-fold; P<0.01).
Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate.
Iwabuchi et al., Urayasu, Japan. In Plos One, 2013
A Pseudomonas aeruginosa-derived neutral ceramidase (PaCDase) isolated from a patient with AD was shown to effectively degrade ceramide in the presence of Staphylococcus aureus-derived lipids or neutral detergents.
Purification and biochemical characterization of membrane-bound neutral ceramidase from camel brain (Camelus dromedarius).
Galadari et al., Ukraine. In Int J Biochem Mol Biol, 2012
In this study, we report the purification and characterization of camel brain neutral ceramidase (CBCDase).
Sphingolipids in psychiatric disorders and pain syndromes.
Kornhuber et al., Erlangen, Germany. In Handb Exp Pharmacol, 2012
Compared to ubiquitously expressed acid sphingomyelinase, acid and neutral ceramidase and neutral sphingomyelinase are highly active in brain regions.
Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development.
Nilsson et al., Lund, Sweden. In Prog Lipid Res, 2009
Metabolism of dietary and membrane sphingolipids in the intestine generates ceramide, sphingosine, sphingosine-1-phosphate, and ceramide-1-phosphate, via the action of alkaline sphingomyelinase, neutral ceramidase, sphingosine-1-kinase, and ceramide-1-kinase.
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate.
Obeid et al., Charleston, United States. In Biochim Biophys Acta, 2008
Presently, 5 human ceramidases encoded by 5 distinct genes have been cloned: acid ceramidase (AC), neutral ceramidase (NC), alkaline ceramidase 1 (ACER1), alkaline ceramidase 2 (ACER2), and alkaline ceramidase 3 (ACER3).
Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.
Igarashi et al., Sapporo, Japan. In Cell Signal, 2007
This review focuses on the metabolic enzymes (acid and alkaline sphingomyelinases, neutral ceramidase, and sphingosine kinase) that are involved in the production of the sphingolipid metabolites in these extracellular spaces, and on the metabolic pathway itself.
Molecular cloning and functional analysis of zebrafish neutral ceramidase.
Ito et al., Fukuoka, Japan. In J Biol Chem, 2004
essential for metabolism of ceramide and the early development of zebrafish.
Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration.
Acharya et al., Frederick, United States. In Science, 2003
Targeted expression of Drosophila neutral ceramidase rescued retinal degeneration in arrestin and phospholipase C mutants.
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