The Protease Ste24 Clears Clogged Translocons.
Israel. In Cell, Feb 2016
To shed light on the machinery required to resolve clogging, we carried out a systematic screen in Saccharomyces cerevisiae that highlighted a role for the ER metalloprotease Ste24.
Fertility of boar semen cryopreserved in extender supplemented with butylated hydroxytoluene.
Kraków, Poland. In Theriogenology, Feb 2015
The sperm quality was verified based on the motility (computer-assisted sperm analysis; total motility, %; progressive motility, %), membrane integrity (YO-PRO-1/propidium iodide [PI] assay), acrosome integrity (fluorescein isothiocyanate-conjugated with peanut agglutinin/PI), and lipid peroxidation (chemiluminescence method) at 15 minutes postthaw.
Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.
Baltimore, United States. In Microbiol Mol Biol Rev, 2012
Notably, studies of the zinc metalloprotease Ste24 in S. cerevisiae led to the discovery of its mammalian homolog ZMPSTE24, which cleaves the prenylated C-terminal tail of the nuclear scaffold protein lamin A. Mutations that alter ZMPSTE24 processing of lamin A in humans cause the premature-aging disease progeria and related progeroid disorders.
Cell autonomous and systemic factors in progeria development.
Oviedo, Spain. In Biochem Soc Trans, 2011
Accordingly, mutations in the LMNA gene and functionally related genes have been described to cause HGPS (Hutchinson-Gilford progeria syndrome), MAD (mandibuloacral dysplasia) or RD (restrictive dermopathy).