gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc metallopeptidase

ZMPSTE24, PRO-1, Ste24, Ste24p, FACE-1
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, lamin A/C, HAD, P2X7
Papers on ZMPSTE24
The Protease Ste24 Clears Clogged Translocons.
New
Impact
Schuldiner et al., Israel. In Cell, Feb 2016
To shed light on the machinery required to resolve clogging, we carried out a systematic screen in Saccharomyces cerevisiae that highlighted a role for the ER metalloprotease Ste24.
LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation.
New
Caron-Debarle et al., Paris, France. In Atherosclerosis, Jan 2016
The metalloprotease ZMPSTE24 is the key enzyme in prelamin A maturation.
Effect of different culture media and deswelling agents on survival of human corneal endothelial and epithelial cells in vitro.
New
Knels et al., Dresden, Germany. In Graefes Arch Clin Exp Ophthalmol, Jan 2016
After 5 days in the test media, cell viability was assessed by flow cytometrically quantifying apoptotic and necrotic cells (sub-G1 DNA content, vital staining with YO-PRO-1® and propidium iodide) and intracellular reactive oxygen species (ROS).
Dietary administration of a commercial mixed-species probiotic improves growth performance and modulates the intestinal immunity of tilapia, Oreochromis niloticus.
New
Merrifield et al., Newport, United Kingdom. In Fish Shellfish Immunol, Jan 2016
Tilapia (29.02 ± 0.33g) were split into five treatments; control (CON), 1.5g kg(-1) probiotic (PRO-1.5),
Tumstatin induces apoptosis mediated by Fas signaling pathway in oral squamous cell carcinoma SCC-VII cells.
New
Chung et al., South Korea. In Oncol Lett, Aug 2015
Apoptosis was characterized by YO-PRO-1 staining, sub-G1 population, and DNA fragmentation analysis.
Fertility of boar semen cryopreserved in extender supplemented with butylated hydroxytoluene.
Review
New
Gogol et al., Kraków, Poland. In Theriogenology, Feb 2015
The sperm quality was verified based on the motility (computer-assisted sperm analysis; total motility, %; progressive motility, %), membrane integrity (YO-PRO-1/propidium iodide [PI] assay), acrosome integrity (fluorescein isothiocyanate-conjugated with peanut agglutinin/PI), and lipid peroxidation (chemiluminescence method) at 15 minutes postthaw.
No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis.
Tenbrock et al., Genève, Switzerland. In Pediatr Rheumatol Online J, 2014
A polymorphism in its promoter region and the genotype IL12p40 pro1.1 leads to a higher production of IL-12p40.
Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.
Impact
Bergo et al., Göteborg, Sweden. In Science, 2013
Several progeroid disorders, including Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (ZMPSTE24 deficiency), arise when a farnesylated and methylated form of prelamin A accumulates at the nuclear envelope.
The structural basis of ZMPSTE24-dependent laminopathies.
Impact
Carpenter et al., Oxford, United Kingdom. In Science, 2013
Mutations in the nuclear membrane zinc metalloprotease ZMPSTE24 lead to diseases of lamin processing (laminopathies), such as the premature aging disease progeria and metabolic disorders.
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.
Impact
Zhou et al., Hong Kong, Hong Kong. In Cell Metab, 2013
SIRT1 exhibits reduced association with nuclear matrix (NM) and decreased deacetylase activity in the presence of progerin or prelamin A, leading to rapid depletion of adult stem cells (ASCs) in Zmpste24(-/-) mice.
Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.
Review
Barrowman et al., Baltimore, United States. In Microbiol Mol Biol Rev, 2012
Notably, studies of the zinc metalloprotease Ste24 in S. cerevisiae led to the discovery of its mammalian homolog ZMPSTE24, which cleaves the prenylated C-terminal tail of the nuclear scaffold protein lamin A. Mutations that alter ZMPSTE24 processing of lamin A in humans cause the premature-aging disease progeria and related progeroid disorders.
Homozygous null mutations in ZMPSTE24 in restrictive dermopathy: evidence of genetic heterogeneity.
GeneRIF
Garg et al., Dallas, United States. In Clin Genet, 2012
A report of a novel and a previously reported homozygous null mutation in ZMPSTE24 in two newborns with restrictive dermopathy.
Cell autonomous and systemic factors in progeria development.
Review
López-Otín et al., Oviedo, Spain. In Biochem Soc Trans, 2011
Accordingly, mutations in the LMNA gene and functionally related genes have been described to cause HGPS (Hutchinson-Gilford progeria syndrome), MAD (mandibuloacral dysplasia) or RD (restrictive dermopathy).
Micromanaging aging with miRNAs: new messages from the nuclear envelope.
Review
López-Otín et al., Oviedo, Spain. In Nucleus, 2011
Recently, we have analyzed the functional relevance of miRNAs in accelerate aging by using Zmpste24-/- mice, a murine model that phenocopies Hutchinson-Gilford progeria syndrome.
Clinical review#: Lipodystrophies: genetic and acquired body fat disorders.
Review
Garg, Dallas, United States. In J Clin Endocrinol Metab, 2011
CIDEC is the disease gene for autosomal recessive, FPL and LMNA and ZMPSTE24 for autosomal recessive, mandibuloacral dysplasia-associated lipodystrophy.
High prevalence of laminopathies among patients with metabolic syndrome.
GeneRIF
Morange et al., Marseille, France. In Hum Mol Genet, 2011
Three of 87 patients with metabolic syndrome carry a heterozygous mutation in LMNA or in ZMPSTE24.
Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice.
GeneRIF
Zhou et al., Hong Kong, Hong Kong. In Proc Natl Acad Sci U S A, 2011
In Zmpste24(-/-) mice, histone H4 was hypoacetylated at a lysine 16 residue (H4K16), and this defect was attributed to the reduced association of a histone acetyltransferase, Mof, to the nuclear matrix.
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.
GeneRIF
López-Otín et al., Oviedo, Spain. In Aging Cell, 2010
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
Early onset mandibuloacral dysplasia due to compound heterozygous mutations in ZMPSTE24.
GeneRIF
Garg et al., Dallas, United States. In Am J Med Genet A, 2010
In patients with mandibuloacral dysplasia due to ZMPSTE24 mutations, the onset of disease manifestations such as thin skin and micrognathia occurs as early as 5 months of age.
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.
Impact
López-Otín et al., Oviedo, Spain. In Nat Med, 2008
Several human progerias, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by the accumulation at the nuclear envelope of farnesylated forms of truncated prelamin A, a protein that is also altered during normal aging.
share on facebooktweetadd +1mail to friends