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Zic family member 4

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: Zic1, CAN, ZIC2, SET, Midline
Papers on Zic4
Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.
Wilkie et al., Bozeman, United States. In Am J Hum Genet, Oct 2015
Heterozygous deletions of ZIC1 and its nearby paralog ZIC4 on chromosome 3q25.1 are associated with Dandy-Walker malformation of the cerebellum, and loss of the orthologous Zic1 gene in the mouse causes cerebellar hypoplasia and vertebral defects.
Stratification based on methylation of TBX2 and TBX3 into three molecular grades predicts progression in patients with pTa-bladder cancer.
Zwarthoff et al., Rotterdam, Netherlands. In Mod Pathol, Apr 2015
We recently demonstrated that methylation of GATA2, TBX2, TBX3, and ZIC4 genes could predict progression in Ta tumors.
Molecular Biology of Pediatric Hydrocephalus and Hydrocephalus-related Diseases.
Kanemura et al., Takatsuki, Japan. In Neurol Med Chir (tokyo), 2014
For DWM, two important loci, 3q24, which includes the FOXC1 gene, and 6q25.3, which includes the ZIC1 and ZIC4 genes, were recently identified as causative areas.
Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer.
Sidransky et al., Baltimore, United States. In Epigenetics, 2014
We uncovered 186 downregulated genes harboring cancer specific promoter methylation including PAX1 and PAX5 and we identified 10 key tumor suppressor genes (GABRB3, HOXC12, PARP15, SLCO4C1, CDKN2A, PAX1, PIK3AP1, HOXC6, PLCB1, and ZIC4) inactivated by both promoter methylation and/or somatic mutation.
Seroprevalence of autoantibodies against brain antigens in health and disease.
Ehrenreich et al., Göttingen, Germany. In Ann Neurol, 2014
All other AB were found in ≤0.1% of individuals (anti-AMPAR-1/2, AQP4, CV2, Tr/DNER, DPPX-IF1, GABAR-B1/B2, GAD67, GLRA1b, GRM1, GRM5, Hu, LGl1, recoverin, Ri, ZIC4).
Genome-wide prediction of cancer driver genes based on SNP and cancer SNV data.
Yu et al., Shanghai, China. In Am J Cancer Res, 2013
NTRK3 and ZIC4) and pathways including oxidative phosphorylation pathway, which were not deemed by previous methods.
Comprehensive methylome analysis of ovarian tumors reveals hedgehog signaling pathway regulators as prognostic DNA methylation biomarkers.
Nephew et al., Taiwan. In Epigenetics, 2013
Concordant hypermethylation and corresponding gene silencing of sonic hedgehog pathway members ZIC1 and ZIC4 in OC tumors was confirmed in a panel of OC cell lines, and ZIC1 and ZIC4 repression correlated with increased proliferation, migration and invasion.
Sequencing of hippocampal and cerebellar transcriptomes provides new insights into the complexity of gene regulation in the human brain.
Janitz et al., Sydney, Australia. In Neurosci Lett, 2013
In cerebellum, the cerebellin 3 precursor (CLBN3) and Zic family member 4 (ZIC4) genes were significantly upregulated.
Modular development of the teleost trunk along the dorsoventral axis and zic1/zic4 as selector genes in the dorsal module.
Takeda et al., Tokyo, Japan. In Development, 2013
Da is an enhancer mutant for zic1 and zic4 in which their expression in dorsal somites is lost.
Dandy-Walker malformation and Wisconsin syndrome: novel cases add further insight into the genotype-phenotype correlations of 3q23q25 deletions.
Valente et al., San Giovanni Rotondo, Italy. In Orphanet J Rare Dis, 2012
The occurrence of overlapping 3q deletions including the ZIC1 and ZIC4 genes in few patients, along with data from mouse models, have implicated both genes in the pathogenesis of DWM.
Antibody repertoire in paraneoplastic cerebellar degeneration and small cell lung cancer.
Graus et al., Barcelona, Spain. In Plos One, 2012
VGCC-ab were measured by RIA, and SOX1-ab, Hu-ab, and ZIC4-ab by immunoblot.
The medaka zic1/zic4 mutant provides molecular insights into teleost caudal fin evolution.
Takeda et al., Tokyo, Japan. In Curr Biol, 2012
We first demonstrate that a large transposon, inserted into the enhancer region of the zic1 and zic4 genes (zic1/zic4) in Da, is associated with the mesoderm-specific loss of their transcription.
NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer.
Zabarovsky et al., Stockholm, Sweden. In Int J Mol Sci, 2011
A set of eight biomarkers: NKIRAS1/RPL15, THRB, RBPS3 (CTDSPL), IQSEC1, NBEAL2, ZIC4, LOC285205 and FOXP1, was identified as the most prominent set capable to detect both early and late stages of ovarian cancer.
Isolated ZIC4 antibodies in paraneoplastic cerebellar syndrome with an underlying ovarian tumor.
Krogias et al., Bochum, Germany. In Arch Neurol, 2011
OBJECTIVE: To describe a patient with paraneoplastic cerebellar syndrome and the uncommon association of isolated ZIC4 antibodies and ovarian cancer.
Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis.
Millen et al., Chicago, United States. In Development, 2011
Zic1 and Zic4 have both Shh-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation.
Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion: Report of a new patient.
Matsumoto et al., Niigata, Japan. In Am J Med Genet A, 2011
Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion.
Differential gene expression in the developing lateral geniculate nucleus and medial geniculate nucleus reveals novel roles for Zic4 and Foxp2 in visual and auditory pathway development.
Sur et al., Cambridge, United States. In J Neurosci, 2009
These findings identify roles for two differentially expressed genes, Zic4 and Foxp2, in the development of the principal auditory relay nucleus, the medial geniculate nucleus, and principal visual relay nucleus, the lateral geniculate nucleus
Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis.
Prince et al., Chicago, United States. In Dev Biol, 2008
Zic1 and Zic4 control zebrafish 4th ventricle morphogenesis by regulating multiple mechanisms including cell proliferation and fate specification in the dorsal hindbrain.
Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family.
Aruga et al., Wako, Japan. In Dev Dyn, 2006
Zic4 expression was detected mainly in the neural plate border, dorsal neural tube, and somites, and was similar to that of Zic1, which is adjacent to Zic4 on the same chromosome.
Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.
Millen et al., Chicago, United States. In Nat Genet, 2004
Through physical mapping of 3q2 interstitial deletions in several individuals with Dandy-Walker malformation (DWM), we defined the first critical region associated with DWM, encompassing two adjacent Zinc finger in cerebellum genes, ZIC1 and ZIC4.
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