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Zic family member 1

Zic1, Zic
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ZIC2, CAN, HTX, Zic4, TUBE
Papers on Zic1
Dysfunctional subcutaneous fat with reduced Dicer and brown adipose tissue gene expression in HIV-infected patients.
Grinspoon et al., Bethesda, United States. In J Clin Endocrinol Metab, Feb 2016
Dicer expression was decreased in abdominal SC fat of HIV vs. non-HIV (4.88 [1.91, 11.93] vs.17.69 [10.72, 47.91], P=0.01), as were PGC1α, ZIC1, PRDM16, DIO2, and HSP60 (all P≤0.03).
Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells.
Takahashi et al., Nagasaki, Japan. In Invest Ophthalmol Vis Sci, Feb 2016
Connexin43 and aquaporin1 were expressed in both thin layers, and induced CE-like cells expressed ciliary marker genes, such as cyclinD2, zic1, tgfb2, aldh1a3, wfdc1, otx1, BMP4, and BMP7.
Regulation of nucleus accumbens transcript levels in mice by early-life social stress and cocaine.
Carola et al., Roma, Italy. In Neuropharmacology, Jan 2016
We characterized 4 candidates with regard to their significant neurobiological relevance (ZIC1, ZIC2, FABP7, and PRDM12) and measured their expression in the NAC by immunohistochemistry.
Clinicopathological significance of increased ZIC1 expression in human endometrial cancer.
Ding et al., Kunshan, China. In J Huazhong Univ Sci Technolog Med Sci, Dec 2015
Zinc finger of the cerebellum (ZIC1), one of ZIC family genes, has been shown to play important roles in many cancers such as gastric cancer and breast cancer.
Dopamine signaling regulates the projection patterns in the mouse chiasm.
Jin et al., Shenzhen, China. In Brain Res, Dec 2015
Furthermore, transcription factor Zic family member 2 (Zic2) upregulated OA1 mRNA expression.
Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.
Wilkie et al., Bozeman, United States. In Am J Hum Genet, Oct 2015
Human ZIC1 (zinc finger protein of cerebellum 1), one of five homologs of the Drosophila pair-rule gene odd-paired, encodes a transcription factor previously implicated in vertebrate brain development.
The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis.
Arkell et al., Leuven, Belgium. In Cell Mol Life Sci, 2013
The zinc finger of the cerebellum gene (ZIC) discovered in Drosophila melanogaster (odd-paired) has five homologs in Xenopus, chicken, mice, and humans, and seven in zebrafish.
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.
Scheele et al., Copenhagen, Denmark. In Cell Metab, 2013
We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26.
Zinc fingers of the cerebellum (Zic): transcription factors and co-factors.
Arkell et al., Canberra, Australia. In Int J Biochem Cell Biol, 2012
The Zic genes encode zinc finger containing proteins that can bind proteins and DNA.
Current perspectives of the signaling pathways directing neural crest induction.
García-Castro et al., New Haven, United States. In Cell Mol Life Sci, 2012
In the first phase, FGF and Wnt signaling induce NC progenitors at the border of the neural plate, activating the expression of members of the Msx, Pax, and Zic families, among others.
Differentiation of definitive endoderm from mouse embryonic stem cells.
Ong et al., Vancouver, Canada. In Results Probl Cell Differ, 2011
Efficient production of definitive endoderm needs to meet the specific criteria that include (a) increase in the production of markers of definitive endoderm such as Sox 17, FOXA2, GSC, and Mixl1; (b) decrease in the production of markers of primitive/visceral/parietal endoderm, Sox 7 and OCT4; and (c) decrease in the mesoderm markers (Brachyury, MEOX) and ectoderm markers (Sox1 and ZIC1).
Gli protein nuclear localization signal.
Aruga et al., Wako, Japan. In Vitam Horm, 2011
Drosophila cubitus interruptus (Ci) and its vertebrate homologues, the glioblastoma (Gli) protein family, are the transcription factors belonging to the metazoan Gli/Glis/Zic ZF protein superfamily that shares similar five tandemly repeated C2H2-type zinc finger (ZF) motifs.
[DNA methylation of ZIC1 and KLOTHO gene promoters in colorectal carcinomas and its clinicopathological significance].
Wang et al., Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, 2011
The down-regulated expression of ZIC1 and KLOTHO in colorectal carcinoma may relate to promoter methylation.
A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis.
Emerson et al., Philadelphia, United States. In Dev Biol, 2011
Myf5 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation, and both Zic2 and Myf5 require noggin for their activation
Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis.
Millen et al., Chicago, United States. In Development, 2011
Zic1 and Zic4 have both Shh-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation.
Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion: Report of a new patient.
Matsumoto et al., Niigata, Japan. In Am J Med Genet A, 2011
Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion.
ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer.
Jin et al., Hangzhou, China. In Plos One, 2010
ZIC1 may potentially function as a tumor suppressor gene
Migratory neural crest-like cells form body pigmentation in a urochordate embryo.
Yamamoto et al., College Park, United States. In Nature, 2004
These cells express HNK-1 antigen and Zic gene markers of vertebrate neural crest cells.
Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.
Millen et al., Chicago, United States. In Nat Genet, 2004
Through physical mapping of 3q2 interstitial deletions in several individuals with Dandy-Walker malformation (DWM), we defined the first critical region associated with DWM, encompassing two adjacent Zinc finger in cerebellum genes, ZIC1 and ZIC4.
Gli/Zic factors pattern the neural plate by defining domains of cell differentiation.
Ruiz i Altaba et al., New York City, United States. In Nature, 1998
We propose that the combined function of Gli/Zic genes responds to inductive signals and induces patterned neural cell differentiation.
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