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Zinc fingers and homeoboxes 3

ZHX3, TIX1
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ZHX1, V1a, CAN, HAD, Tec
Papers on ZHX3
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
T2D-GENES consortium and GoT2D consortium et al., Oxford, United Kingdom. In Plos Genet, 2015
Coding variant associations for glycemic traits in GWAS signals highlight PCSK1, RREB1, and ZHX3 as likely effector transcripts.
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia.
Hegele et al., London, Canada. In Circ Cardiovasc Genet, 2012
METHODS AND RESULTS: We resequenced protein coding regions of 3 genes with established roles (APOC2, GPIHBP1, LMF1) and 2 genes recently implicated (CREB3L3 and ZHX3) in TG metabolism.
Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation.
GeneRIF
Kato et al., Nagasaki, Japan. In Stem Cells Dev, 2011
ZHX3 is involved in the switch from the undifferentiated state of mesenchymal stem cells to an osteogenic program
The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension.
Folkers et al., Utrecht, Netherlands. In Biochemistry, 2009
The high degree of sequence conservation among ZHX family members permitted us to prepare homology models for ZHX2 and ZHX3, revealing distinct surface characteristics for each family member.
ZHX2 and ZHX3 repress cancer markers in normal hepatocytes.
Miyamoto et al., Fukui, Japan. In Front Biosci, 2008
ZHX2 and ZHX3 are the members of the ZHX transcriptional repressor family.
ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.
GeneRIF
Chugh et al., Chicago, United States. In J Biol Chem, 2007
ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease
The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3.
Miyamoto et al., Fukui, Japan. In Gene, 2004
Human zinc-fingers and homeoboxes (ZHX) 1, ZHX2 and ZHX3, members of the ZHX family, contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs).
Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.
GeneRIF
Miyamoto et al., Fukui, Japan. In Biochem J, 2003
dimerizes with both ZHX1 and ZHX3, also interacts with the activation domain of the NF-YA
Searching for type 2 diabetes genes on chromosome 20.
Glaser et al., Saint Louis, United States. In Diabetes, 2002
The SNP association study showed that SNP rs2664537 in the TIX1 gene had a significant P value of 0.035, but the finding did not replicate in an additional case pool.
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