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Ring finger protein 212

ZHP-3, RNF212
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: CAN, MSH4, Smt3, Smo, V1a
Papers on ZHP-3
Controlling meiotic recombinational repair - specifying the roles of ZMMs, Sgs1 and Mus81/Mms4 in crossover formation.
Fung et al., San Francisco, United States. In Plos Genet, 2014
Our results suggest that Zip3 (RNF212) promotes biased cutting of the double Holliday-junction (dHJ) intermediate whereas surprisingly Msh4 does not.
Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
Cohen et al., Stanford, United States. In J Cell Biol, 2014
Disruption of Cntd1 results in failure to localize CO-specific factors MutLγ and HEI10 at designated CO sites and also leads to prolonged high levels of pre-CO intermediates marked by MutSγ and RNF212.
Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
Impact
Hunter et al., Davis, United States. In Nat Genet, 2014
Designation of crossovers involves selective localization of the SUMO ligase RNF212 to a minority of recombination sites, where it stabilizes pertinent factors such as MutSγ (ref.
Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line.
La Volpe et al., Napoli, Italy. In Cell Death Differ, 2013
We show that CO-promoting factors MSH-4, MSH-5, and ZHP-3, but not COSA-1, are required for the apoptotic response of the meiotic DNA damage checkpoint.
RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis.
Impact
Hunter et al., Davis, United States. In Nat Genet, 2013
A putative regulator of crossing-over is RNF212, which is associated with variation in crossover rates in humans.
The role of rice HEI10 in the formation of meiotic crossovers.
Cheng et al., Beijing, China. In Plos Genet, 2012
Together our results suggest that HEI10 is the homolog of budding yeast Zip3 and Caenorhabditis elegans ZHP-3, and may specifically promote class I CO formation through modification of various meiotic components.
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
Georges et al., Liège, Belgium. In Plos Genet, 2011
We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.
Variation in human recombination rates and its genetic determinants.
Przeworski et al., Chicago, United States. In Plos One, 2010
We replicated associations of RNF212 with the mean rate in males and in females as well as the association of Inversion 17q21.31 with the female mean rate.
Genetic analysis of variation in human meiotic recombination.
Cheung et al., Philadelphia, United States. In Plos Genet, 2009
Two of these (RNF212 and an inversion on chromosome 17q21.31)
ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and bivalent formation in C. elegans.
Dernburg et al., Berkeley, United States. In Plos Genet, 2008
zhp-3, the Caenorhabditis elegans ortholog of the budding yeast ZIP3 gene, is required for crossover recombination.
Sequence variants in the RNF212 gene associate with genome-wide recombination rate.
Impact
GeneRIF
Stefansson et al., Reykjavík, Iceland. In Science, 2008
genome search identified sequence variants in the 4p16.3 region correlated with recombination rate in males & females; variants are located in the RNF212 gene, a putative ortholog of ZHP-3 gene essential for recombination & chiasma formation in C elegans
Targeted gene knockout reveals a role in meiotic recombination for ZHP-3, a Zip3-related protein in Caenorhabditis elegans.
GeneRIF
Loidl et al., Vienna, Austria. In Mol Cell Biol, 2004
This paper describes a partial transcript of the human RNF212 gene.
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