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Zinc finger protein, Y-linked

ZFY
This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ZFX, SRY, POLYMERASE, CAN, HAD
Papers on ZFY
Strong and Stable Geographic Differentiation of Swamp Buffalo Maternal and Paternal Lineages Indicates Domestication in the China/Indochina Border Region.
New
Barker et al., Beijing, China. In Mol Ecol, Jan 2016
We carried out a comprehensive sampling of China, Taiwan, Vietnam, Laos, Thailand, Nepal and Bangladesh and sequenced the mtDNA Cytochrome b gene and control region and the Y-chromosomal ZFY, SRY and DBY sequences.
Identification of Y-Chromosome Sequences in Turner Syndrome.
New
Balarin et al., Uberaba, Brazil. In Indian J Pediatr, Jan 2016
Genomic DNA was also extracted from peripheral blood lymphocytes, and gene sequences DYZ1, DYZ3, ZFY and SRY were amplified by Polymerase Chain Reaction.
DDX3Y, a Male-Specific Region of Y Chromosome Gene, May Modulate Neuronal Differentiation.
New
Salekdeh et al., Tehrān, Iran. In J Proteome Res, Oct 2015
The expression level of 12 Y-linked genes significantly increased over neural differentiation, including RBMY1, EIF1AY, DDX3Y, HSFY1, BPY2, PCDH11Y, UTY, RPS4Y1, USP9Y, SRY, PRY, and ZFY.
Genome-wide Evidence Reveals that African and Eurasian Golden Jackals Are Distinct Species.
New
Wayne et al., Washington, D.C., United States. In Curr Biol, Sep 2015
To test the distinct-species hypothesis and understand the evolutionary history that would account for this puzzling result, we analyzed extensive genomic data including mitochondrial genome sequences, sequences from 20 autosomal loci (17 introns and 3 exon segments), microsatellite loci, X- and Y-linked zinc-finger protein gene (ZFX and ZFY) sequences, and whole-genome nuclear sequences in African and Eurasian golden jackals and gray wolves.
Genome-Wide Search Identifies 1.9 Mb from the Polar Bear Y Chromosome for Evolutionary Analyses.
New
Janke et al., Garching bei München, Germany. In Genome Biol Evol, Jul 2015
Moreover, we find evidence of gene conversion among ZFX and ZFY sequences in the giant panda lineage and in the ancestor of ursine and tremarctine bears.
Cell culture, sex determination and single cell cloning of ovine transgenic satellite cells in vitro.
Cao et al., Beijing, China. In J Biol Res (thessalon), 2014
BACKGROUND: This study was performed to describe the basic methods to isolate and culture of primary satellite cells (PSCs) obtained from 50 to 60-day-old sheep fetuses, single cell cloning of transfected PSCs and sexing of ovine PSCs based on the ZFY/ZFX, amelogenin and high-motility-group (HMG) box sequences.
Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
GeneRIF
Mitchell et al., Marseille, France. In Hum Mol Genet, 2012
Studies identified a major testis-specific ZFY transcript that encodes a protein with the same short acidic domain.
Sex-chromosome linked gene expression in in-vitro produced bovine embryos.
GeneRIF
King et al., Finland. In Mol Hum Reprod, 2002
ZFY transcripts were detected in unsexed pools of 8-16-cell stage embryos and in male blastocysts.
[Azoospermia and genetic mutations: implications for the methods of in vitro fertilization].
Review
Isidori et al., Roma, Italy. In Minerva Endocrinol, 1996
Furthermore other genes on the short arm seem to have a role during spermatogenesis: they are called ZFY (zink finger Y, which encodes a DNA binding protein) and TSPY (expressed in the spermatids nuclei); but the function of these genes is still uncertain, since at this moment no deletions or mutations have been found at this level.
The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning.
Review
Impact
Chandler et al., London, United Kingdom. In Annu Rev Immunol, 1996
The Hya/HYA gene(s) encoding H-Y antigen have been mapped using translocations, mutations, and deletions to Yq in humans and to the short arm of the Y chromosome in mice, where they lie in the deletion defined by the Sxrb mutation between Zfy-1 and Zfy-2.
Aetiology of intersexuality in female (XX) pigs, with novel molecular interpretations.
Review
Hunter, Edinburgh, United Kingdom. In Mol Reprod Dev, 1996
Molecular probing has failed to reveal the classical sex-determining gene, Sry, and other Y-related DNA sequences such as Zfy and DYZI in almost all the intersex animals examined.
Identification of a mouse male-specific transplantation antigen, H-Y.
Impact
Mitchell et al., London, United Kingdom. In Nature, 1995
In the mouse, the gene(s) controlling H-Y expression (Hya) are located on the short arm of the Y chromosome between the zinc-finger genes Zfy-1 and Zfy-2.
Absence of polymorphism at the ZFY locus on the human Y chromosome.
Impact
Gilbert et al., New Haven, United States. In Science, 1995
DNA polymorphism in the Y chromosome, examined at a 729-base pair intron located immediately upstream of the ZFY zinc-finger exon, revealed no sequence variation in a worldwide sample of 38 human males.
Preimplantation single cell analyses of dystrophin gene deletions using whole genome amplification.
Impact
Hughes et al., Houston, United States. In Nat Genet, 1994
We report the simultaneous analysis of single cells at five commonly deleted dystrophin exons and at the ZFX/ZFY loci.
[Human Y chromosome in reproduction and development].
Review
Nakahori et al., Tokyo, Japan. In Nihon Rinsho, 1993
They included colony stimulating factor receptor (CSF2R), SRY (TDF), ZFY, RPS4Y (ribosome protein 4S), ADMLY (Kallman syndrome), AMGL (amelogenin, which we cloned ourselves) and so on.
Chromosomal localisation of a gene(s) for Turner stigmata on Yp.
Review
Turner et al., London, United Kingdom. In J Med Genet, 1993
In addition, assessment of ZFX/ZFY and RPS4X/RPS4Y in the context of the Turner gene(s) suggests that ZFX/ZFY rather than RPS4X/RPS4Y could be a candidate gene for the Turner stigmata.
Male-driven evolution of DNA sequences.
Impact
Li et al., Houston, United States. In Nature, 1993
As the number of X-linked genes used in the study was small and the X-linked and autosomal sequences were non-homologous, and given that the synonymous rate varies among genes, we sequenced the last intron (approximately 1 kb) of the Y-linked and X-linked zinc-finger-protein genes (ZFY and ZFX) in humans, orang-utans, baboons and squirrel monkeys.
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