Identification of novel genetic causes of Rett syndrome-like phenotypes.
Guimarães, Portugal. In J Med Genet, Feb 2016
deletion encompassing four exons of the TCF4 gene and a mosaic UPD of chromosome 3. Variants in genes previously implicated in neurodevelopmental disorders (NDD) were identified in six patients (32%): de novo variants in EEF1A2, STXBP1 and ZNF238 were found in three patients, maternally inherited X linked variants in SLC35A2, ZFX and SHROOM4 were detected in two male patients and one homozygous variant in EIF2B2 was detected in one patient.
Clinicopathological correlates of hyperparathyroidism.
Toronto, Canada. In J Clin Pathol, Oct 2015
Recently, molecular mechanisms underlying possible tumour suppressor genes (MEN1, CDC73/HRPT2, CDKIs, APC, SFRPs, GSK3β, RASSF1A, HIC1, RIZ1, WT1, CaSR, GNA11, AP2S1) and proto-oncogenes (CCND1/PRAD1, RET, ZFX, CTNNB1, EZH2) have been uncovered in the pathogenesis of hyperparathyroidism.
Diverse roles of jasmonates and ethylene in abiotic stress tolerance.
Brisbane, Australia. In Trends Plant Sci, Apr 2015
Major JA and ET signaling hubs such as JAZ proteins, CTR1, MYC2, components of the mediator complex, EIN2, EIN3, and several members of the AP2/ERF transcription factor gene family all have complex regulatory roles during abiotic stress adaptation.
Novel players fine-tune plant trade-offs.
Madrid, Spain. In Essays Biochem, 2014
The bioactive form of the hormone, (+)-7-iso-jasmonyl-L-isoleucine (JA-Ile), is perceived by the COI1-JAZ co-receptor complex.
Jasmonate signaling and crosstalk with gibberellin and ethylene.
Beijing, China. In Curr Opin Plant Biol, 2014
In response to the JA signal, the CORONATINE INSENSITIVE 1 (COI1)-based SCF complexes recruit JASMONATE ZIM-domain (JAZ) repressors for ubiquitination and degradation, and subsequently regulate their downstream signaling components essential for various JA responses.
Light regulation of plant defense.
Buenos Aires, Argentina. In Annu Rev Plant Biol, 2013
Inactivation of phytochrome B by low red:far-red ratios appears to suppress jasmonate responses by altering the balance between DELLA and JASMONATE ZIM DOMAIN (JAZ) proteins in favor of the latter.