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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger protein, autosomal

ZFX, Zfa, JAZ
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ZFY, ACID, CAN, POLYMERASE, SCF
Papers using ZFX antibodies
Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response*
Supplier
Arai Hiroyuki et al., In The Journal of Biological Chemistry, 2006
... Benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK) and benzyloxycarbonyl-Phe-Ala-fluoromethyl ketone (Z-FA-FMK) were obtained from BioVision (Mountain View, CA) ...
Papers on ZFX
Identification of novel genetic causes of Rett syndrome-like phenotypes.
New
Maciel et al., Guimarães, Portugal. In J Med Genet, Feb 2016
deletion encompassing four exons of the TCF4 gene and a mosaic UPD of chromosome 3. Variants in genes previously implicated in neurodevelopmental disorders (NDD) were identified in six patients (32%): de novo variants in EEF1A2, STXBP1 and ZNF238 were found in three patients, maternally inherited X linked variants in SLC35A2, ZFX and SHROOM4 were detected in two male patients and one homozygous variant in EIF2B2 was detected in one patient.
Clinicopathological correlates of hyperparathyroidism.
Review
New
Mete et al., Toronto, Canada. In J Clin Pathol, Oct 2015
Recently, molecular mechanisms underlying possible tumour suppressor genes (MEN1, CDC73/HRPT2, CDKIs, APC, SFRPs, GSK3β, RASSF1A, HIC1, RIZ1, WT1, CaSR, GNA11, AP2S1) and proto-oncogenes (CCND1/PRAD1, RET, ZFX, CTNNB1, EZH2) have been uncovered in the pathogenesis of hyperparathyroidism.
Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
New
Impact
He et al., Grand Rapids, United States. In Nature, Oct 2015
Key mediators of jasmonate signalling include MYC transcription factors, which are repressed by jasmonate ZIM-domain (JAZ) transcriptional repressors in the resting state.
Zinc finger protein X-linked is overexpressed in colorectal cancer and is associated with poor prognosis.
New
Liu et al., Jiaxing, China. In Oncol Lett, Aug 2015
UNASSIGNED: Zinc finger protein X-linked (ZFX) is a zinc finger transcription factor and plays a significant role in the self-renewal ability of embryonic stem cells and various cancers.
Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
New
Melcher et al., Shanghai, China. In Sci Adv, Jul 2015
To understand the structural basis of this interaction, we determined the crystal structures of the TPD of rice (Os) TPR2 in apo (apo protein) state and in complexes with the EAR motifs from Arabidopsis NINJA (novel interactor of JAZ), IAA1 (auxin-responsive protein 1), and IAA10, key transcriptional repressors involved in jasmonate and auxin signaling.
Diverse roles of jasmonates and ethylene in abiotic stress tolerance.
Review
New
Kazan, Brisbane, Australia. In Trends Plant Sci, Apr 2015
Major JA and ET signaling hubs such as JAZ proteins, CTR1, MYC2, components of the mediator complex, EIN2, EIN3, and several members of the AP2/ERF transcription factor gene family all have complex regulatory roles during abiotic stress adaptation.
Expression of ZFX gene correlated with the central features of the neoplastic phenotype in human brain tumors with distinct phenotypes.
Kheirollahi et al., Sārī, Iran. In Adv Biomed Res, 2014
BACKGROUND: The zinc finger transcription factor zinc finger protein, X-linked (ZFX) acts as an important director of self-renewal in several stem cell types.
Novel players fine-tune plant trade-offs.
Review
Solano et al., Madrid, Spain. In Essays Biochem, 2014
The bioactive form of the hormone, (+)-7-iso-jasmonyl-L-isoleucine (JA-Ile), is perceived by the COI1-JAZ co-receptor complex.
JAZ Repressors: Potential Involvement in Nutrients Deficiency Response in Rice and Chickpea.
Giri et al., New Delhi, India. In Front Plant Sci, 2014
Jasmonate ZIM domain (JAZ) proteins are plant-specific proteins and act as transcriptional repressors of JA-responsive genes.
Jasmonate signaling and crosstalk with gibberellin and ethylene.
Review
Xie et al., Beijing, China. In Curr Opin Plant Biol, 2014
In response to the JA signal, the CORONATINE INSENSITIVE 1 (COI1)-based SCF complexes recruit JASMONATE ZIM-domain (JAZ) repressors for ubiquitination and degradation, and subsequently regulate their downstream signaling components essential for various JA responses.
Perception, signaling and cross-talk of jasmonates and the seminal contributions of the Daoxin Xie's lab and the Chuanyou Li's lab.
Review
Wasternack, Halle, Germany. In Plant Cell Rep, 2014
For JA-Ile perception, the SCF(COI1)-JAZ co-receptor complex has been identified and crystalized.
Light regulation of plant defense.
Review
Impact
Ballaré, Buenos Aires, Argentina. In Annu Rev Plant Biol, 2013
Inactivation of phytochrome B by low red:far-red ratios appears to suppress jasmonate responses by altering the balance between DELLA and JASMONATE ZIM DOMAIN (JAZ) proteins in favor of the latter.
JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1.
GeneRIF
May et al., Gainesville, United States. In Cell Cycle, 2011
JAZ directly binds E2F1 in vitro in a dsRNA-independent manner, and JAZ's dsRNA binding ZF domains, which are necessary for localizing JAZ to the nucleus, are required for repression of transcriptional activity in vivo.
Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
Impact
Zheng et al., Seattle, United States. In Nature, 2010
The F-box protein CORONATINE INSENSITIVE 1 (COI1) mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JAZ proteins.
NINJA connects the co-repressor TOPLESS to jasmonate signalling.
Impact
Goossens et al., Gent, Belgium. In Nature, 2010
JA-Ile-responsive gene expression is regulated by the transcriptional activator MYC2 that interacts physically with the jasmonate ZIM-domain (JAZ) repressor proteins.
Jasmonate passes muster: a receptor and targets for the defense hormone.
Review
Impact
Browse, Pullman, United States. In Annu Rev Plant Biol, 2008
Transcriptional profiling led to the discovery of the JASMONATE ZIM-DOMAIN (JAZ) proteins, which are repressors of JA signaling.
JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity.
GeneRIF
May et al., Gainesville, United States. In Blood, 2007
JAZ is a novel negative regulator of cell growth by positively regulating p53.
Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.
GeneRIF
Macara et al., Charlottesville, United States. In Mol Cell Biol, 2004
JAZ is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism
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