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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Mar 2014.

Zinc finger protein 57 homolog

The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: CAN, TIF1beta, HAD, ZFP, ACID
Papers on ZFP57
Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57.
Knight et al., Oxford, United Kingdom. In Eur J Hum Genet, 30 Apr 2014
ZFP57 is an important transcriptional regulator involved in DNA methylation and genomic imprinting during development.
High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism.
Peluso et al., Napoli, Italy. In Cancer Biol Ther, 11 Apr 2014
We measured the mRNA levels of ZFP57, TRIM28, CPT1A, CPT1B, and CPT1C in a cohort of 80 patients divided in two groups: grade II and grade IV.
Molecular Reproduction & Development Volume 81, Issue 2, February 2014 cover image.
In Mol Reprod Dev, 28 Feb 2014
Maternally supplied ZFP57 and its cofactor TRIM28 protect gDMRs from demethylation processes by recruiting additional epigenetic modifiers, which maintain parent-specific DNA methylation.
The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells.
Koide et al., Kanazawa, Japan. In Oncogene, 27 Feb 2014
The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell differentiation.
DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å.
Cheng et al., Atlanta, United States. In Biochemistry, Jan 2014
The Zfp57 gene encodes a KRAB (Krüppel-associated box) domain-containing C2H2 zinc finger transcription factor that is expressed in early development.
Human and mouse ZFP57 proteins are functionally interchangeable in maintaining genomic imprinting at multiple imprinted regions in mouse ES cells.
Li et al., New York City, United States. In Epigenetics, Dec 2013
ZFP57 is a master regulator in genomic imprinting.
Dynamics of imprinted DNA methylation and gene transcription for imprinting establishment in mouse oocytes in relation to culture duration variability.
Smitz et al., Brussels, Belgium. In Biol Reprod, Dec 2013
Furthermore, we studied the dynamics during follicle culture of transcript levels for genes previously shown to be essential for imprinting establishment in oocytes, including Dnmt3a, Dnmt3L, and Zfp57.
Genes, assisted reproductive technology and trans-illumination.
Maher et al., Birmingham, United Kingdom. In Epigenomics, Jun 2013
Studies of rare human imprinting disorders such as familial hydatidiform mole, Beckwith-Wiedemann syndrome and familial transient neonatal diabetes mellitus have enabled the identification of genetic (e.g., mutations in KHDC3L [C6ORF221], NLRP2 [NALP2], NLRP7 [NALP7] and ZFP57) and environmental (assisted reproductive technologies) factors that can disturb the normal trans mechanisms for imprinting establishment and/or maintenance.
Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1.
Pedone et al., Caserta, Italy. In Febs Lett, Jun 2013
In the mouse, ZFP57 contains three classical Cys2His2 zinc finger domains (ZF) and recognizes the methylated TGC(met)CGC target sequence using the first and the second ZFs.
On how mammalian transcription factors recognize methylated DNA.
Defossez et al., Salt Lake City, United States. In Epigenetics, Feb 2013
The last piece of the puzzle has been recently revealed by the structural resolution of two different zinc finger proteins, Kaiso and ZFP57, in complex with methylated DNA.
Transient neonatal diabetes mellitus in a Turkish patient with three novel homozygous variants in the ZFP57 gene.
Mackay et al., İstanbul, Turkey. In J Clin Res Pediatr Endocrinol, 2012
To describe the findings in a Turkish male patient with NDM caused by a loss of methylation at chromosome 6q24 and three novel homozygous mutations in the ZFP57 gene, methylation-specific PCR was carried out at 6q24 and mutation analysis of ZFP57 gene was maintained by direct sequencing.
Genomic imprinting is a parental effect established in mammalian germ cells.
Li, New York City, United States. In Curr Top Dev Biol, 2012
Maintenance of the DNA methylation imprint is dependent on two distinct maternal effect genes (Zfp57 and PGC7/Stella).
Proteins involved in establishment and maintenance of imprinted methylation marks.
Ferguson-Smith et al., Cambridge, United Kingdom. In Brief Funct Genomics, 2012
Specifically, we discuss the recent findings of a critical role played by a KRAB zinc-finger protein ZFP57 and its co-factor KAP1/TRIM28 in mediating both processes.
No evidence for pathogenic variants or maternal effect of ZFP57 as the cause of Beckwith-Wiedemann Syndrome.
Grønskov et al., Glostrup, Denmark. In Eur J Hum Genet, 2012
no evidence for ZFP57 alterations as a major cause in sporadic Beckwith-Wiedemann Syndrome cases
6q24 transient neonatal diabetes.
Shield et al., Southampton, United Kingdom. In Rev Endocr Metab Disord, 2010
In some individuals, diabetes may be the initial presentation of a more complex imprinting disorder due to recessive mutations in the gene ZFP57 and may be associated with other developmental problems.
Screening for genomic variants in ZFP57 in Silver-Russell syndrome patients with 11p15 epimutations.
Eggermann et al., Aachen, Germany. In Eur J Med Genet, 2009
this study does not provide evidence that ZFP57 mutations are the cause of 11p15-hypomethylation in Silver-Russell syndrome (SRS) patients and contribute to the aetiology of SRS
Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57.
Temple et al., Southampton, United Kingdom. In Nat Genet, 2008
Study reports mutations in ZFP57, which encodes a zinc-finger transcription factor expressed in early development, in seven pedigrees with a shared pattern of mosaic hypomethylation and a conserved range of clinical features.
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