The specification of imprints in mammals.
Cambridge, United Kingdom. In Heredity (edinb), Aug 2014
Among the factors involved in this selection, the zinc-finger protein Zfp57 can be regarded as an imprint-specific, sequence-specific DNA binding factor responsible for maintaining methylation at most ICRs.
A familial disorder of altered DNA-methylation.
Kiel, Germany. In J Med Genet, Jun 2014
Sanger sequencing and RT-PCR of imprinting-associated genes (NLRP2, NLRP7, ZFP57, KHDC3L, DNMT1o), exome sequencing and locus-specific, array-based and genome-wide technologies to determine DNA-methylation were performed.
Genes, assisted reproductive technology and trans-illumination.
Birmingham, United Kingdom. In Epigenomics, Jun 2013
Studies of rare human imprinting disorders such as familial hydatidiform mole, Beckwith-Wiedemann syndrome and familial transient neonatal diabetes mellitus have enabled the identification of genetic (e.g., mutations in KHDC3L [C6ORF221], NLRP2 [NALP2], NLRP7 [NALP7] and ZFP57) and environmental (assisted reproductive technologies) factors that can disturb the normal trans mechanisms for imprinting establishment and/or maintenance.
6q24 transient neonatal diabetes.
Southampton, United Kingdom. In Rev Endocr Metab Disord, 2010
In some individuals, diabetes may be the initial presentation of a more complex imprinting disorder due to recessive mutations in the gene ZFP57 and may be associated with other developmental problems.