GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Zinc finger protein 57 homolog
ZFP57
The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009] (from
NCBI)
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Papers on
ZFP57
Transient Neonatal Diabetes, ZFP57, and Hypomethylation of Multiple Imprinted Loci: A detailed follow-up.
New
In Diabetes Care, 31 Mar 2013
RESEARCH DESIGN AND METHODS The 10 families (14 homozygous/compound heterozygous individuals) with ZFP57 mutations were ascertained through TNDM1 diagnostic testing.
On how mammalian transcription factors recognize methylated DNA.
New
Salt Lake City, United States. In Epigenetics, 01 Mar 2013
The last piece of the puzzle has been recently revealed by the structural resolution of two different zinc finger proteins, Kaiso and ZFP57, in complex with methylated DNA.
Estrus synchronization and ovarian hyper-stimulation treatments have negligible effects on cumulus oocyte complex gene expression whereas induction of ovulation causes major expression changes.
New
United States. In Mol Reprod Dev, 28 Feb 2013
Conversely, G + E + H(trt) downregulated genes encoding proteins involved in: DNA replication and cell cycle progression (Ccne2, Orc5l, Rad50, and Mcm6); reproductive developmental process; and granulosa cell expansion (Gdf9, Bmp15, Amh, Amhr2, Bmpr1b, Tgfb2, Foxl2, Pde3a, Esr2, Fshr, Ybx2, Ccnd2, Ccnb1ip1, and Zp3); maternal effect genes required for embryo development (Zar1, Npm2, Nlrp5, Dnmt1, H1foo, and Zfp57); amino acid degradation; and ketogenesis (Hmgcs2, and Cpt1b).
Genome-wide allelic methylation analysis reveals disease-specific susceptibility to multiple methylation defects in imprinting syndromes.
New
Barcelona, Spain. In Hum Mutat, 18 Feb 2013
A mutation analysis identified a 1 bp deletion in the ZFP57 gene in a TNDM patient with methylation defects at multiple maternal DMRs.
Genomic imprinting is a parental effect established in mammalian germ cells.
New
New York City, United States. In Curr Top Dev Biol, Dec 2012
Maintenance of the DNA methylation imprint is dependent on two distinct maternal effect genes (Zfp57 and PGC7/Stella).
An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence.
New
Atlanta, United States. In Genes Dev, Dec 2012
Zinc finger transcription factor Zfp57 recognizes the methylated CpG within the TGCCGC element.
Nanog regulates molecules involved in stemness and cell cycle-signaling pathway for maintenance of pluripotency of P19 embryonal carcinoma stem cells.
New
Seoul, South Korea. In J Cell Physiol, Nov 2012
However, expressions of pluripotency markers Cripto, germ cell nuclear factor, Sox2, and Zfp57 as well as leukemia inhibitory factor (LIF)/Stat3 pathway molecules LIF, IL6st, and Stat3 were not affected after 48 h transfection with Nanog siRNA or construct.
Should I stay or should I go: protection and maintenance of DNA methylation at imprinted genes.
New
Singapore, Singapore. In Epigenetics, Sep 2012
It is just recently that the molecular players that protect/maintain imprinting marks during reprogramming in preimplantation embryos have been identified, in particular, an epigenetic modifier complex formed by ZFP57 and TRIM28/KAP1.
Proteins involved in establishment and maintenance of imprinted methylation marks.
Review
New
Cambridge, United Kingdom. In Brief Funct Genomics, May 2012
Specifically, we discuss the recent findings of a critical role played by a KRAB zinc-finger protein ZFP57 and its co-factor KAP1/TRIM28 in mediating both processes.
Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain.
New
New York City, United States. In J Biol Chem, Feb 2012
Previously, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains DNA methylation genomic imprint at multiple imprinted regions in mouse embryos.
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions.
Lausanne, Switzerland. In Mol Cell, 2011
Here, we reveal that ZFP57, its cofactor KAP1, and associated effectors bind selectively to the H3K9me3-bearing, DNA-methylated allele of ICRs in ES cells.
ZFP57: KAPturing DNA methylation at imprinted loci.
Philadelphia, United States. In Mol Cell, 2011
In this issue of Molecular Cell, Quenneville et al. (2011) characterize the role of ZFP57 in the maintenance of DNA methylation at imprinting control regions (ICRs), revealing an allele-specific binding pattern, binding motif, and interactions with other epigenetic regulators.
6q24 transient neonatal diabetes.
Review
Southampton, United Kingdom. In Rev Endocr Metab Disord, 2010
In some individuals, diabetes may be the initial presentation of a more complex imprinting disorder due to recessive mutations in the gene ZFP57 and may be associated with other developmental problems.
Transient neonatal diabetes mellitus type 1.
Review
Southampton, United Kingdom. In Am J Med Genet C Semin Med Genet, 2010
Over half of patients with maternal hypomethylation at the TNDM1 locus have additional hypomethylation of other maternally methylated imprinted genes throughout the genome, and the majority of these patients have mutations in the transcription factor ZFP57. TNDM1 with maternal hypomethylation has also been observed in patients conceived by assisted reproduction, and in discordant monozygotic twins.
Screening for genomic variants in ZFP57 in Silver-Russell syndrome patients with 11p15 epimutations.
GeneRIF
Aachen, Germany. In Eur J Med Genet, 2009
this study does not provide evidence that ZFP57 mutations are the cause of 11p15-hypomethylation in Silver-Russell syndrome (SRS) patients and contribute to the aetiology of SRS
Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57.
Impact
GeneRIF
Southampton, United Kingdom. In Nat Genet, 2008
Study reports mutations in ZFP57, which encodes a zinc-finger transcription factor expressed in early development, in seven pedigrees with a shared pattern of mosaic hypomethylation and a conserved range of clinical features.
