Gene expression regulation in roots under drought.
Katowice, Poland. In J Exp Bot, Jan 2016
In particular, the role of several transcription factor (TF) families, including DREB, AP2/ERF, NAC, bZIP, MYC, CAMTA, Alfin-like and Q-type ZFP, in the regulation of root response to drought are highlighted.
KAPtain in charge of multiple missions: Emerging roles of KAP1.
Duarte, United States. In World J Biol Chem, 2014
KAP1/TRIM28/TIF1β was identified nearly twenty years ago as a universal transcriptional co-repressor because it interacts with a large KRAB-containing zinc finger protein (KRAB-ZFP) transcription factor family.
Hematopoietic fingerprints: an expression database of stem cells and their progeny.
Houston, United States. In Cell Stem Cell, 2007
In overexpression studies, two of these genes, Zfp 105 from the NK cell lineage, and Ets2 from the monocyte lineage, were able to significantly influence differentiation toward their respective lineages, demonstrating the utility of the fingerprints for identifying genes that regulate differentiation.
Drug discovery with engineered zinc-finger proteins.
Richmond, United States. In Nat Rev Drug Discov, 2003
These proteins have been used as the DNA-binding domains of novel transcription factors (ZFP TFs), which are useful for validating genes as drug targets and for engineering cell lines for small-molecule screening and protein production.