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Zinc finger, CCHC domain containing 11

ZCCHC11, TUT4, zinc finger, CCHC domain containing 11
ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011] (from NCBI)
Top mentioned proteins: Lin28, Dicer, miR, LIN28B, CAN
Papers on ZCCHC11
A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B.
New
Miyazono et al., Cambridge, United States. In Cancer Sci, Sep 2015
Lin28A selectively inhibits let-7 biogenesis through cytoplasmic uridylation of precursor let-7 by TUT4 terminal uridyl transferase and subsequent degradation by Dis3l2 exonuclease.
TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.
New
Kim et al., Seoul, South Korea. In Embo J, Aug 2015
We find that the overhang of a pre-miRNA is the key structural element that is recognized by TUT7 and its paralogues, TUT4 (ZCCHC11) and TUT2 (GLD2/PAPD4).
Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2.
New
Lieberman et al., Boston, United States. In Cell Rep, Jun 2015
These tails are added by the terminal uridylyl transferases (TUTases) ZCCHC6 and ZCCHC11, and the uridylated transcript intermediates are degraded by the 3' to 5' exonuclease DIS3L2.
Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.
New
Gilbert et al., Oxford, United Kingdom. In Nucleic Acids Res, Apr 2015
The Schizosaccharomyces pombe TUT Cid1 is a model enzyme that has been characterized structurally at moderate resolution and provides insights into the larger and more complex mammalian TUTs, ZCCHC6 and ZCCHC11.
Improved crystallization and diffraction of caffeine-induced death suppressor protein 1 (Cid1).
New
Gilbert et al., Oxford, United Kingdom. In Acta Crystallogr Sect F Struct Biol Commun, Mar 2015
In metazoans, the Cid1 orthologues ZCCHC6 and ZCCHC11 uridylate histone mRNAs, targeting them for degradation, but also uridylate microRNAs, altering their maturation.
SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs.
Impact
Lee et al., Taej┼Ćn, South Korea. In Cell Stem Cell, 2015
LIN28A is believed to act primarily in the cytoplasm together with TUT4/7 to prevent final maturation of let-7 by Dicer, whereas LIN28B has been suggested to preferentially act on nuclear processing of let-7.
Uridylation by TUT4 and TUT7 marks mRNA for degradation.
Impact
Kim et al., Seoul, South Korea. In Cell, 2015
By applying TAIL-seq, we identify TUT4 and TUT7 (TUT4/7), also known as ZCCHC11 and ZCCHC6, respectively, as mRNA uridylation enzymes.
Identification of small molecule inhibitors of Zcchc11 TUTase activity.
Gregory et al., Boston, United States. In Rna Biol, 2014
Lin28 recruits the 3' terminal uridylyl transferase (TUTase) Zcchc11 (TUT4) and/or Zcchc6 (TUT7) to precursor let-7 RNA (pre-let-7) to selectively block let-7 biogenesis.
Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway.
Impact
Joshua-Tor et al., New York City, United States. In Nature, 2014
Lin28 binds to precursor let-7 (pre-let-7) hairpins, triggering the 3' oligo-uridylation activity of TUT4 and TUT7 (refs 10-12).
Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).
Gregory et al., Boston, United States. In Nucleic Acids Res, 2014
Here we describe the ability for two related terminal uridyl transferases (TUTases), Zcchc6 (TUT7) and Zcchc11 (TUT4), to 3' mono-uridylate a specific subset of miRNAs involved in cell differentiation and Homeobox (Hox) gene control.
A MicroRNA precursor surveillance system in quality control of MicroRNA synthesis.
Mourelatos et al., Philadelphia, United States. In Mol Cell, 2014
We find widespread and extensive uridylation of Argonaute (Ago)-bound pre-miRNAs, which is primarily catalyzed by two terminal uridylyltransferases: TUT7 and TUT4.
The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein.
Kim et al., South Korea. In Biochim Biophys Acta, 2014
For instance, Lin28B and its paralog, Lin28A, inhibit the pre-let-7 precursor from being processed to mature miRNA by recruiting terminal uridyltransferase, TUT4, which adds oligomeric U at the 3' end, suggesting that deregulation of Lin28B, together with Lin28A, may alter various biological processes through modulation of let-7 expression.
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs.
Vanacova et al., In Rna, 2013
Only recently, 3' uridylation via LIN28A-TUT4/7 has been recognized as an essential component controlling the biogenesis of let-7 miRNAs in stem cells.
Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.
Impact
Kim et al., Seoul, South Korea. In Cell, 2012
We identify TUT7/ZCCHC6, TUT4/ZCCHC11, and TUT2/PAPD4/GLD2 as the terminal uridylyl transferases responsible for pre-miRNA mono-uridylation.
Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity.
GeneRIF
Mizgerd et al., Boston, United States. In J Biol Chem, 2012
Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.
Impact
Gregory et al., Boston, United States. In Cell, 2011
Lin28A recruits a TUTase (Zcchc11/TUT4) to let-7 precursors to block processing by Dicer in the cell cytoplasm.
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.
GeneRIF
Gregory et al., Boston, United States. In Nat Struct Mol Biol, 2009
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
Zcchc11-dependent uridylation of microRNA directs cytokine expression.
Impact
GeneRIF
Mizgerd et al., Boston, United States. In Nat Cell Biol, 2009
Zcchc11 fine tunes IL-6 production by uridylating miR-26a.
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.
Impact
GeneRIF
Kim et al., Seoul, South Korea. In Cell, 2009
This study uncovers the role of TUT4 and Lin28 as specific suppressors of microRNA biogenesis, which has implications for stem cell research and cancer biology.
A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.
GeneRIF
Yoshimura et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2006
We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB.
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