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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger and BTB domain containing 2

ZBTB2
Top mentioned proteins: p21, SP1, V1a, p16, p53
Papers on ZBTB2
ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65.
New
Hur et al., Seoul, South Korea. In Nucleic Acids Res, Mar 2015
ZBTB2 represses transcription of the gene by inhibiting Sp1 binding to a Sp1-binding GC-box in the RelA/p65 proximal promoter (bp, -31 to -21).
DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation.
Breton et al., Grenoble, France. In Biochem Biophys Res Commun, 2014
We found that the putative oncoprotein Zinc finger and BTB domain-containing protein 2 (ZBTB2) is associated with methylated DNA sequences and that this interaction is inhibited by the presence of 5-hmC replacing 5-mC.
Identification of candidate oncogenes in human colorectal cancers with microsatellite instability.
Aaltonen et al., Helsinki, Finland. In Gastroenterology, 2013
Potential mutation hot spots were confirmed in 15 genes; ADAR, DCAF12L2, GLT1D1, ITGA7, MAP1B, MRGPRX4, PSRC1, RANBP2, RPS6KL1, SNCAIP, TCEAL6, TUBB6, WBP5, VEGFB, and ZBTB2; these were validated in 86 tumors with microsatellite instability.
MicroRNA-149 inhibits proliferation and cell cycle progression through the targeting of ZBTB2 in human gastric cancer.
Fan et al., Xi'an, China. In Plos One, 2011
Moreover, ectopic expression of miR-149 in gastric cancer cells inhibits proliferation and cell cycle progression by down-regulating ZBTB2, a potent repressor of the ARF-HDM2-p53-p21 pathway, with a potential binding site for miR-149 in its mRNA's 3'UTR.
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
Lipton et al., Seoul, South Korea. In Blood, 2011
Candidate genes in those regions include RMND1, AKAP12, ZBTB2, and WSB1.
ZBTB2, a novel master regulator of the p53 pathway.
GeneRIF
Hur et al., Seoul, South Korea. In J Biol Chem, 2009
ZBTB2 is a potential proto-oncogenic master control gene of the p53 pathway and, in particular, is a potent transcription repressor of the cell cycle arrest gene p21 by inhibiting p53 and Sp1
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