Identification of candidate oncogenes in human colorectal cancers with microsatellite instability.
Helsinki, Finland. In Gastroenterology, 2013
Potential mutation hot spots were confirmed in 15 genes; ADAR, DCAF12L2, GLT1D1, ITGA7, MAP1B, MRGPRX4, PSRC1, RANBP2, RPS6KL1, SNCAIP, TCEAL6, TUBB6, WBP5, VEGFB, and ZBTB2; these were validated in 86 tumors with microsatellite instability.
ZBTB2, a novel master regulator of the p53 pathway.
Seoul, South Korea. In J Biol Chem, 2009
ZBTB2 is a potential proto-oncogenic master control gene of the p53 pathway and, in particular, is a potent transcription repressor of the cell cycle arrest gene p21 by inhibiting p53 and Sp1