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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Achaete-scute complex-like 1a

zash1a, ascl1a, ash1a, achaete-scute homolog 1a, achaete-scute complex-like 1a
Top mentioned proteins: FATE, CAN, AKA, V1a, Pax6
Papers on zash1a
Wnt/βcatenin-signaling and the formation of Müller glia-derived progenitors in the chick retina.
New
Fischer et al., United States. In Dev Neurobiol, Jan 2016
Inhibition of Wnt-signaling with XAV939 in damaged retinas suppressed the formation of MGPCs, increased expression of ascl1a and decreased hes5, but had no effect upon the differentiation of progeny produced by MGPCs.
Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs.
New
Chen et al., Nashville, United States. In Genetics, Jun 2015
We also show that delivery of sgRNAs targeting ascl1a into the eye leads to impaired damage-induced photoreceptor regeneration.
Leptin and IL-6 family cytokines synergize to stimulate Müller glia reprogramming and retina regeneration.
Goldman et al., Ann Arbor, United States. In Cell Rep, 2014
Importantly, we find that ascl1a gene expression, which drives MG reprogramming in fish and mammals, is regulated in a Jak/Stat-dependent manner and requires consensus Stat-binding sites for injury-dependent activation.
Reactive microglia and macrophage facilitate the formation of Müller glia-derived retinal progenitors.
Todd et al., Columbus, United States. In Glia, 2014
With the microglia ablated in damaged retinas, levels of Notch and related genes were unchanged or increased, whereas levels of ascl1a, TNFα, IL1β, complement component 3 (C3) and C3a receptor were significantly reduced.
Subdivisions of the adult zebrafish pallium based on molecular marker analysis.
Brand et al., Dresden, Germany. In F1000res, 2013
Combinatorial expression analysis of ascl1a, eomesa, emx1, emx2, emx3, and Prox1 identifies four main divisions in the adult zebrafish pallium.
Molecular and cellular characterization of a zebrafish optic pathway tumor line implicates glia-derived progenitors in tumorigenesis.
McGrail et al., Ames, United States. In Plos One, 2013
qRT-PCR confirmed >10-fold overexpression of the Wnt pathway components hbegfa, ascl1a, and insm1a.
Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system.
Review
Wallace et al., United States. In Adv Exp Med Biol, 2013
This review highlights studies that have already been performed using proteomic techniques and as well as our initial proteomic work comparing changes to the proteome between the ascl1a-/- and WT intestine.
The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon.
Ekker et al., Ottawa, Canada. In Dev Biol, 2013
Here, we have examined the regulatory relationships between the ascl1a, dlx, and gad1b genes in the zebrafish forebrain.
Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility.
Wallace et al., United States. In Dev Biol, 2013
Here, we demonstrate that in contrast to the atoh1 in mammals, ascl1a is responsible for formation of secretory cells in zebrafish.
The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine.
Voz et al., Liège, Belgium. In Dev Biol, 2013
Loss-of-function analyses using the pia/ascl1a mutant, revealed that ascl1a is crucial for the differentiation of all secretory cells.
Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina.
Impact
Goldman et al., Ann Arbor, United States. In Nat Cell Biol, 2012
Insm1a was found to suppress ascl1a and its own expression, and link injury-dependent ascl1a induction with the suppression of the Wnt inhibitor dickkopf (dkk), which is necessary for MG dedifferentiation.
Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain.
Guo et al., Shanghai, China. In J Neurosci, 2012
First, our genetic analyses reveal the requirement of the achaete-scute-like genes ascl1a and 1b in serotonergic and GABAergic neuron development, but they are dispensable for the specification of dopaminergic neurons, which is dependent on the atonal-like gene neurog1.
HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration.
Goldman et al., Ann Arbor, United States. In Dev Cell, 2012
We show that HB-EGF mediates its effects via an EGFR/MAPK signal transduction cascade that regulates the expression of regeneration-associated genes, like ascl1a and pax6(b).
Injury-dependent Müller glia and ganglion cell reprogramming during tissue regeneration requires Apobec2a and Apobec2b.
Goldman et al., Ann Arbor, United States. In J Neurosci, 2012
The maximal induction of apobec2b required Ascl1a, but was independent of Lin28, and therefore defines an independent signaling pathway stemming from Ascl1a.
Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration.
GeneRIF
Goldman et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2011
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt signaling inhibitor, Dkk, and induced expression of the Wnt ligand, Wnt4a.
Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway.
Impact
GeneRIF
Goldman et al., Ann Arbor, United States. In Nat Cell Biol, 2010
The Ascl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway.
The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration.
GeneRIF
Goldman et al., Ann Arbor, United States. In J Neurosci, 2008
ascl1a is essential for retina regeneration: within 4 h after retinal injury, ascl1a is induced in Muller glia.
Cellular correlates of proneural and Notch-delta gene expression in the regenerating zebrafish retina.
GeneRIF
Cameron et al., Syracuse, United States. In Vis Neurosci, 2007
Cellular correlates of proneural gene(ash1a) expression in the regenerating zebrafish retina.
The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis.
GeneRIF
Hammerschmidt et al., Freiburg, Germany. In Development, 2006
Ascl1a might act downstream of diencephalic fibroblast growth factor 3 (Fgf3) signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis
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