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Dual specificity phosphatase 12

YVH1, Yvh1p, DUSP12, dual specificity phosphatase 12
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: fibrillin-1, ATF6, iMpact, Inactive, ACID
Papers using YVH1 antibodies
Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover
Johnson Arlen W. et al., In The Journal of Cell Biology, 1998
... DUSP12, amplified from a cDNA clone (MGC:10337; IMAGE:3958403; Open Biosystems) by using primers DUSP12-F2 and DUSP12-R2, was cloned into p415GPD cut with BamHI and HindIII by using the In-Fusion Advantage PCR Cloning kit (Clontech Laboratories, Inc.) to generate ...
Papers on YVH1
Common genetic variants in NEFL influence gene expression and neuroblastoma risk.
Maris et al., Napoli, Italy. In Cancer Res, 2015
In a genome-wide association study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma heritability.
Transcriptome comparisons identify new cell markers for theca interna and granulosa cells from small and large antral ovarian follicles.
Rodgers et al., Adelaide, Australia. In Plos One, 2014
Many genes up regulated in theca interna were common to both sizes of follicles (MGP, DCN, ASPN, ALDH1A1, COL1A2, FN1, COL3A1, OGN, APOD, COL5A2, IGF2, NID1, LHFP, ACTA2, DUSP12, ACTG2, SPARCL1, FILIP1L, EGFLAM, ADAMDEC1, HPGD, COL12A1, FBLN5, RAMP2, COL15A1, PLK2, COL6A3, LOXL1, RARRES1, FLI1, LAMA2).
Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren's syndrome.
Arcos-Burgos et al., Canberra, Australia. In J Transl Med, 2014
RESULTS: Eleven novel and rare functional variants were identified in cases but not in controls, harboured in: MACF1, KIAA0754, DUSP12, ICA1, CELA1, LRP1/STAT6, GRIN3B, ANKLE1, TMEM161A, and FKRP.
Investigating redox regulation of protein tyrosine phosphatases using low pH thiol labeling and enrichment strategies coupled to MALDI-TOF mass spectrometry.
Vacratsis et al., Windsor, Canada. In Methods, 2014
Mercury immobilized metal affinity chromatography (Hg-IMAC) demonstrated high selectivity and specificity while enriching for thiol-containing peptides from the atypical dual specificity phosphatase hYVH1 (also known as DUSP12).
Differential expression of inflammation-related genes in the ovarian stroma and granulosa cells of PCOS women.
Brännström et al., Göteborg, Sweden. In Mol Hum Reprod, 2014
The growth factor DUSP12 and the coagulation factor TFPI2 were over-expressed.
Protein tyrosine phosphatase profiling studies during brown adipogenic differentiation of mouse primary brown preadipocytes.
Bae et al., Taejŏn, South Korea. In Bmb Rep, 2013
Several PTPs, including PTPRF, PTPRZ, and DUSP12 showing differential expression patterns were identified.
Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations.
Yegnasubramanian et al., Baltimore, United States. In Oncotarget, 2013
DUSP12, MARCKS), and cell proliferation (MYCN, TIMELESS); downregulation of pro-differentiation and TGF-β/BMP signaling pathways; upregulation of oxidative metabolism and DNA repair pathways; and activation of inflammatory cytokines, including CCL2, and multiple oncogenes (e.g., CCND1).
Replication of GWAS-identified neuroblastoma risk loci strengthens the role of BARD1 and affirms the cumulative effect of genetic variations on disease susceptibility.
Iolascon et al., Napoli, Italy. In Carcinogenesis, 2013
Several neuroblastoma (NB) susceptibility loci have been identified within LINC00340, BARD1, LMO1, DUSP12, HSD17B12, DDX4, IL31RA, HACE1 and LIN28B by genome-wide association (GWA) studies including European American individuals.
Genetic interactions of ribosome maturation factors Yvh1 and Mrt4 influence mRNA decay, glycogen accumulation, and the expression of early meiotic genes in Saccharomyces cerevisiae.
Harashima et al., Suita, Japan. In J Biochem, 2011
the interaction between Mrt4 and Yvh1 is also essential for normal glycogen accumulation and mRNA decay as well as the induction of sporulation genes
The dual-specificity phosphatase hYVH1 (DUSP12) is a novel modulator of cellular DNA content.
Vacratsis et al., Windsor, Canada. In Cell Cycle, 2011
hYVH1 is a novel modulator of cell cycle progression mediated by a phosphorylation site located at the C-terminal end of the zinc-binding domain
Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility Loci.
Maris et al., Philadelphia, United States. In Plos Genet, 2011
Here we show that a GWAS focused on low-risk cases identified SNPs within DUSP12 at 1q23.3 (P = 2.07 × 10⁻⁶), DDX4 and IL31RA both at 5q11.2 (P = 2.94 × 10⁻⁶ and 6.54 × 10⁻⁷ respectively), and HSD17B12 at 11p11.2 (P = 4.20 × 10⁻⁷) as being associated with the less aggressive form of the disease.
Characterization of a human cell line stably over-expressing the candidate oncogene, dual specificity phosphatase 12.
Beeser et al., Manhattan, United States. In Plos One, 2010
propose that the BRC repeats in BRCA2 cooperate in a partially redundant but reinforcing manner to ensure a high probability of RAD51 filament formation
Lack of association between genetic polymorphisms within DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese population.
Jia et al., Shanghai, China. In Bmc Med Genet, 2010
these data suggests common SNPs within DUSP12-ATF6 locus may not play a major role in glucose metabolism in the Chinese.
Gold nanoparticle enrichment method for identifying S-nitrosylation and S-glutathionylation sites in proteins.
Mutus et al., Windsor, Canada. In J Am Chem Soc, 2010
Here, protein disulfide isomerase (PDI) and dual specificity phosphatase 12 (DUSP12 or hYVH1) were S-nitrosylated or S-glutathionylated, their free thiols differentially alkylated, and subjected to proteolysis.
Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells.
Wu et al., Boston, United States. In Cancer Res, 2010
tudies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML.
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