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TRNA-yW synthesizing protein 1 homolog

Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: fibrillin-1, PPM2, STEP, FACT, OUT
Papers on YPL207w
Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.
Suzuki et al., Tokyo, Japan. In Embo J, 2006
Four genes YPL207w, YML005w, YGL050w and YOL141w (named TYW1, TYW2, TYW3 and TYW4, respectively) were essential for yW synthesis.
Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis.
Suzuki et al., Tokyo, Japan. In Nucleic Acids Symp Ser (oxf), 2005
We found four new genes YPL207w, YML005w, YOL141w and YGL050w (named TYW1, TYW2, TYW3 and TYW4, respectively) to be responsible for wybutosine (yW) synthesis.
Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs.
Schimmel et al., Los Angeles, United States. In J Biol Chem, 2005
Gene knock-out and complementation studies in Saccharomyces cerevisiae established a role for YPL207w, a COG0731 ortholog that encodes an 810-amino acid polypeptide.
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