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Chitinase 3-like 1

YKL-40, CHI3L1, HC gp-39, cartilage glycoprotein-39
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Chitinase, HAD, AGE, CD45, CAN
Papers on YKL-40
The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases.
Hartl et al., Basel, Switzerland. In Mol Cell Pediatr, 31 Dec 2015
Particularly, increased levels of the chitinase-like protein YKL-40 have been associated with severe asthma, cystic fibrosis, and other inflammatory disease conditions.
Urinary markers in the early stage of nephropathy in patients with childhood-onset type 1 diabetes.
Suh et al., Seoul, South Korea. In Pediatr Nephrol, 02 Dec 2015
BACKGROUND: The aim of this study was to evaluate the association of a urinary tubular marker, liver-type fatty acid binding protein (L-FABP) and an inflammatory marker, serum/urinary YKL-40, with albuminuria in patients with childhood-onset type 1 diabetes (T1D).
Molecular phenotyping of clinical AKI with novel urinary biomarkers.
Parikh et al., New Haven, United States. In Am J Physiol Renal Physiol, Oct 2015
We will discuss two AKI biomarkers, neutrophil gelatinase-associated lipocalin (NGAL) and breast regression protein-39 (BRP-39)/YKL-40, that exemplify the need to characterize the complexity of the biological meaning behind the biomarker, beyond elevated levels reporting on tissue injury.
YKL-40: may be use as a new inflammatory biomarker in obstructive sleep apnea syndrome?
Kurt et al., Ankara, Turkey. In Tuberk Toraks, Sep 2015
Introduction: YKL-40 [chitinase-3 like-1 (CHI3L1)] is a glycoprotein, has been implicated in inflammation, endothelial dysfunction, tissue remodelling and it is accepted as a noninvasive prognostic biomarker for inflammation.
YKL-40/CHI3L1 drives inflammation on the road of tumor progression.
Iragavarapu-Charyulu et al., Boca Raton, United States. In J Leukoc Biol, Sep 2015
YKL-40/chitinase-3-like-1 protein is often up-regulated in inflammation-associated diseases.
Chitinase-3-like-1/YKL-40 as marker of circulating tumor cells.
Burghuber et al., Vienna, Austria. In Transl Lung Cancer Res, Jun 2015
Permanent CTC cultures of different patients shared secretion of chitinase-3-like-1 (CHI3L1)/YKL-40, known to be upregulated in a range of tumor entities and to be associated with increased metastasis and decreased survival.
OSAS-related inflammatory mechanisms of liver injury in nonalcoholic fatty liver disease.
Nobili et al., Torino, Italy. In Mediators Inflamm, Dec 2014
In this review, we focus on molecular mechanisms linking OSAS to NAFLD, including hypoxia inducible factor (HIF), nuclear factor kappa B (NF-κB), YKL-40, unfolded protein response, and hypoxic adipose tissue inflammation, which all could provide novel potential therapeutic approaches for the management of NAFLD patients with OSAS.
The Role of CHI3L1 (Chitinase-3-Like-1) in the Pathogenesis of Infections in Burns in a Mouse Model.
Yarmush et al., Boston, United States. In Plos One, Dec 2014
In this context we investigated the role of the mammalian Chitinase-3-Like-1 (CHI3L1) non-enyzmatic protein predominately expressed on epithelial as well as innate immune cells as a potential bacterial-translocation-mediating factor.
Blood-based Biomarkers at Large Bowel Endoscopy and Prediction of Future Malignancies.
Nielsen et al., Hvidovre, Denmark. In Biomark Cancer, Dec 2014
Plasma levels of TIMP-1, CEA, CA19-9, and YKL-40 were determined in samples collected just before endoscopy and compared with subsequent development of a malignant disease within a period of 7-8 years.
Biomarkers of progression of chronic obstructive pulmonary disease (COPD).
Yang et al., Brisbane, Australia. In J Thorac Dis, Nov 2014
Examples of peripheral blood biological markers (biomarkers) include those associated with lung function (reduced CC-16), emphysema severity (increased adiponectin, reduced sRAGE), exacerbations and mortality [increased CRP, fibrinogen, leukocyte count, IL-6, IL-8, and tumor necrosis factor α (TNF-α)] including increased YKL-40 with mortality.
Promoter polymorphisms in CHI3L1 are associated with asthma.
Sinnett et al., In J Allergy Clin Immunol, 2012
rs4950928 and rs10399931 promoter polymorphisms in CHI3L1 are equally likely to modulate CHI3L1 expression and susceptibility to asthma in Caucasian and African populations.
Extent of tumor removal and molecular markers in cerebral glioblastoma: a combined prognostic factors study in a surgical series of 105 patients.
Santoro et al., Roma, Italy. In J Neurosurg, 2012
When biological aggressiveness is taken into account, YKL-40 expression was found to be an independent prognostic factor that predicts OS better than MGMT status.
Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease.
Park et al., Iksan, South Korea. In Cytokine, 2012
Serum YKL-40 levels are highest during pneumonia compared to common pulmonary/pleural diseases and are more useful for monitoring pneumonia than asthma
YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes.
Schernthaner et al., Zürich, Switzerland. In Atherosclerosis, 2012
YKL-40 is higher in subjects with peripheral arterial disease. YKL-40 was higher in PAD patients with pre-/diabetes.
Involvement of the MAPK and PI3K pathways in chitinase 3-like 1-regulated hyperoxia-induced airway epithelial cell death.
Sohn et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
This study indicates that CHI3L1 is involved in hyperoxia-induced cell death, suggesting that CHI3L1 may be one of several cell death regulators influencing the MAPK and PI3K pathways during oxidative stress in human airway epithelial cells.
Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population.
Nordestgaard et al., Copenhagen, Denmark. In J Clin Oncol, 2009
PURPOSE: Elevated plasma YKL-40 is a biomarker of poor prognosis in cancer patients.
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Chupp et al., Chicago, United States. In N Engl J Med, 2008
CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.
A chitinase-like protein in the lung and circulation of patients with severe asthma.
Elias et al., New Haven, United States. In N Engl J Med, 2007
The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum.
Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma.
Aldape et al., Houston, United States. In J Clin Oncol, 2007
These data were then examined in conjunction with the expression of phospho-intermediates (in a subset of these patients) of downstream AKT and Ras pathways and YKL-40 as well as with known clinical risk factors, including the Radiation Therapy Oncology Group's recursive partitioning analysis (RTOG-RPA) class.
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