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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Chitinase 3-like 1

YKL-40, CHI3L1, HC gp-39, cartilage glycoprotein-39
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Chitinase, HAD, AGE, CD45, CAN
Papers on YKL-40
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
New
Girkontaitė et al., Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
RESULTS: Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls.
YKL-40/chitinase-3-like protein 1 is associated with poor prognosis and promotes cell growth and migration of cholangiocarcinoma.
New
Talabnin et al., Nakhon Ratchasima, Thailand. In Tumour Biol, Feb 2016
UNASSIGNED: YKL-40, a chitinase-like glycoprotein, is expressed at a high level in cancer patients.
Are SMAD7 rs4939827 and CHI3L1 rs4950928 polymorphisms associated with colorectal cancer in Egyptian patients?
New
Kamal et al., Cairo, Egypt. In Tumour Biol, Feb 2016
The CHI3L1 gene encodes glycoprotein YKL-40, which plays a role in cell proliferation, anti-apoptosis, and angiogenesis.
Cerebrospinal fluid neurogranin and YKL-40 as biomarkers of Alzheimer's disease.
New
Hansson et al., Malmö, Sweden. In Ann Clin Transl Neurol, Jan 2016
Novel and promising CSF biomarkers include neurogranin, a marker of synaptic degeneration, and YKL-40, a marker of neuroinflammation.
Vascular heterogeneity and targeting: the role of YKL-40 in glioblastoma vascularization.
Review
New
Schwartz et al., Amherst Center, United States. In Oncotarget, Jan 2016
This review focuses on recent discoveries that the angiogenic factor YKL-40 (CHI3L1) acts on glioblastoma-stem like cells (GSCs) to drive the formation of two major forms of tumor vascularization: angiogenesis and vasculogenic mimicry (VM).
YKL-40/CHI3L1 drives inflammation on the road of tumor progression.
Review
New
Iragavarapu-Charyulu et al., Boca Raton, United States. In J Leukoc Biol, Dec 2015
YKL-40/chitinase-3-like-1 protein is often up-regulated in inflammation-associated diseases.
Biomarkers in multiple sclerosis.
Review
New
Hafler et al., New Haven, United States. In Clin Immunol, Nov 2015
We go on to discuss other potential biomarkers from MS serum and cerebrospinal fluid including Markers of neurodegeneration including neurofilament and GFAP, the monocyte macrophage marker CD163, the glial activation marker YKL-40, the B cell chemoattractant CXCL13, miRNA and mRNA, myelin reactive t cells, Kir4.1 antibodies, osteopontin, and microbiome associated lipopeptides.
Molecular phenotyping of clinical AKI with novel urinary biomarkers.
Review
New
Parikh et al., New Haven, United States. In Am J Physiol Renal Physiol, Oct 2015
We will discuss two AKI biomarkers, neutrophil gelatinase-associated lipocalin (NGAL) and breast regression protein-39 (BRP-39)/YKL-40, that exemplify the need to characterize the complexity of the biological meaning behind the biomarker, beyond elevated levels reporting on tissue injury.
Chitinase-3-like-1/YKL-40 as marker of circulating tumor cells.
Review
New
Burghuber et al., Vienna, Austria. In Transl Lung Cancer Res, Jun 2015
Permanent CTC cultures of different patients shared secretion of chitinase-3-like-1 (CHI3L1)/YKL-40, known to be upregulated in a range of tumor entities and to be associated with increased metastasis and decreased survival.
Correlation between serum YKL-40 levels and albuminuria in type 2 diabetes.
Wang et al., Shenyang, China. In Genet Mol Res, 2014
We explored the correlation between serum YKL-40 levels and albuminuria in type 2 diabetes mellitus (T2DM) and its clinical significance.
Promoter polymorphisms in CHI3L1 are associated with asthma.
GeneRIF
Sinnett et al., In J Allergy Clin Immunol, 2012
rs4950928 and rs10399931 promoter polymorphisms in CHI3L1 are equally likely to modulate CHI3L1 expression and susceptibility to asthma in Caucasian and African populations.
Extent of tumor removal and molecular markers in cerebral glioblastoma: a combined prognostic factors study in a surgical series of 105 patients.
GeneRIF
Santoro et al., Roma, Italy. In J Neurosurg, 2012
When biological aggressiveness is taken into account, YKL-40 expression was found to be an independent prognostic factor that predicts OS better than MGMT status.
Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease.
GeneRIF
Park et al., Iksan, South Korea. In Cytokine, 2012
Serum YKL-40 levels are highest during pneumonia compared to common pulmonary/pleural diseases and are more useful for monitoring pneumonia than asthma
YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes.
GeneRIF
Schernthaner et al., Zürich, Switzerland. In Atherosclerosis, 2012
YKL-40 is higher in subjects with peripheral arterial disease. YKL-40 was higher in PAD patients with pre-/diabetes.
Involvement of the MAPK and PI3K pathways in chitinase 3-like 1-regulated hyperoxia-induced airway epithelial cell death.
GeneRIF
Sohn et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
This study indicates that CHI3L1 is involved in hyperoxia-induced cell death, suggesting that CHI3L1 may be one of several cell death regulators influencing the MAPK and PI3K pathways during oxidative stress in human airway epithelial cells.
Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population.
Impact
Nordestgaard et al., Copenhagen, Denmark. In J Clin Oncol, 2009
PURPOSE: Elevated plasma YKL-40 is a biomarker of poor prognosis in cancer patients.
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Impact
GeneRIF
Chupp et al., Chicago, United States. In N Engl J Med, 2008
CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.
A chitinase-like protein in the lung and circulation of patients with severe asthma.
Impact
Elias et al., New Haven, United States. In N Engl J Med, 2007
The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum.
Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma.
Impact
Aldape et al., Houston, United States. In J Clin Oncol, 2007
These data were then examined in conjunction with the expression of phospho-intermediates (in a subset of these patients) of downstream AKT and Ras pathways and YKL-40 as well as with known clinical risk factors, including the Radiation Therapy Oncology Group's recursive partitioning analysis (RTOG-RPA) class.
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