gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Chitinase 3-like 1

YKL-40, CHI3L1, HC gp-39, cartilage glycoprotein-39
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Chitinase, HAD, AGE, CD45, CAN
Papers on YKL-40
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
New
Girkontaitė et al., Vilnius, Lithuania. In Int Arch Allergy Immunol, 21 Feb 2016
RESULTS: Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls.
YKL-40/chitinase-3-like protein 1 is associated with poor prognosis and promotes cell growth and migration of cholangiocarcinoma.
New
Talabnin et al., Nakhon Ratchasima, Thailand. In Tumour Biol, 19 Feb 2016
UNASSIGNED: YKL-40, a chitinase-like glycoprotein, is expressed at a high level in cancer patients.
Are SMAD7 rs4939827 and CHI3L1 rs4950928 polymorphisms associated with colorectal cancer in Egyptian patients?
New
Kamal et al., Cairo, Egypt. In Tumour Biol, 16 Feb 2016
The CHI3L1 gene encodes glycoprotein YKL-40, which plays a role in cell proliferation, anti-apoptosis, and angiogenesis.
Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma.
New
Kim et al., Seoul, South Korea. In Pulm Pharmacol Ther, 08 Feb 2016
The levels of neutrophil elastase, Interleukin (IL)-8, and BRP-39 (human homologue YKL-40) were assessed.
YKL-40 as marker of severe lung disease in cystic fibrosis patients.
New
Salpietro et al., Catania, Italy. In J Cyst Fibros, 08 Feb 2016
BACKGROUND: YKL-40 is a chitinase-like protein present in serum of healthy subjects and its levels are increased in several human inflammatory diseases.
Role of chitinase-like proteins in cancer.
New
Mitrofanova et al., In Biol Chem, 05 Feb 2016
Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells, macrophages, neutrophils, synoviocytes, chondrocytes and other cells.
Cerebrospinal fluid neurogranin and YKL-40 as biomarkers of Alzheimer's disease.
New
Hansson et al., Malmö, Sweden. In Ann Clin Transl Neurol, 31 Jan 2016
Novel and promising CSF biomarkers include neurogranin, a marker of synaptic degeneration, and YKL-40, a marker of neuroinflammation.
Clinical significance of serum YKL-40 in Behçet's disease.
New
Kim et al., Seoul, South Korea. In Br J Dermatol, 26 Jan 2016
BACKGROUND: Serum YKL-40 is an inflammatory biomarker of endothelial dysfunction and may play a role in the inflammatory process of Behçet's disease (BD).
Effect analysis of early bedside hemo-filtration in treatment of severe pneumonia with acute renal failure of children.
New
Li et al., Xuzhou, China. In Eur Rev Med Pharmacol Sci, 31 Dec 2015
After treatment for 7 days, IL-6 and TNF-α, YKL-40 and Annexin A1 levels of the experimental group were significantly lower than those of the control group.
Correlation between serum YKL-40 levels and albuminuria in type 2 diabetes.
Wang et al., Shenyang, China. In Genet Mol Res, 2014
We explored the correlation between serum YKL-40 levels and albuminuria in type 2 diabetes mellitus (T2DM) and its clinical significance.
Promoter polymorphisms in CHI3L1 are associated with asthma.
GeneRIF
Sinnett et al., In J Allergy Clin Immunol, 2012
rs4950928 and rs10399931 promoter polymorphisms in CHI3L1 are equally likely to modulate CHI3L1 expression and susceptibility to asthma in Caucasian and African populations.
Extent of tumor removal and molecular markers in cerebral glioblastoma: a combined prognostic factors study in a surgical series of 105 patients.
GeneRIF
Santoro et al., Roma, Italy. In J Neurosurg, 2012
When biological aggressiveness is taken into account, YKL-40 expression was found to be an independent prognostic factor that predicts OS better than MGMT status.
Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease.
GeneRIF
Park et al., Iksan, South Korea. In Cytokine, 2012
Serum YKL-40 levels are highest during pneumonia compared to common pulmonary/pleural diseases and are more useful for monitoring pneumonia than asthma
YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes.
GeneRIF
Schernthaner et al., Zürich, Switzerland. In Atherosclerosis, 2012
YKL-40 is higher in subjects with peripheral arterial disease. YKL-40 was higher in PAD patients with pre-/diabetes.
Involvement of the MAPK and PI3K pathways in chitinase 3-like 1-regulated hyperoxia-induced airway epithelial cell death.
GeneRIF
Sohn et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
This study indicates that CHI3L1 is involved in hyperoxia-induced cell death, suggesting that CHI3L1 may be one of several cell death regulators influencing the MAPK and PI3K pathways during oxidative stress in human airway epithelial cells.
Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population.
Impact
Nordestgaard et al., Copenhagen, Denmark. In J Clin Oncol, 2009
PURPOSE: Elevated plasma YKL-40 is a biomarker of poor prognosis in cancer patients.
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Impact
GeneRIF
Chupp et al., Chicago, United States. In N Engl J Med, 2008
CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.
A chitinase-like protein in the lung and circulation of patients with severe asthma.
Impact
Elias et al., New Haven, United States. In N Engl J Med, 2007
The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum.
Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma.
Impact
Aldape et al., Houston, United States. In J Clin Oncol, 2007
These data were then examined in conjunction with the expression of phospho-intermediates (in a subset of these patients) of downstream AKT and Ras pathways and YKL-40 as well as with known clinical risk factors, including the Radiation Therapy Oncology Group's recursive partitioning analysis (RTOG-RPA) class.
share on facebooktweetadd +1mail to friends