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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Oct 2014.

Chitinase 3-like 1

YKL-40, CHI3L1, HC gp-39, cartilage glycoprotein-39
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Chitinase, HAD, CD45, AGE, CAN
Papers on YKL-40
Serum YKL-40 is increased in patients with slow coronary flow.
New
Pan et al., Nantong, China. In Coron Artery Dis, 29 Nov 2014
YKL-40 has been suggested to be a potential biomarker of inflammation.
Plasma YKL-40 in Inuit and Danes.
New
Becker et al., Copenhagen, Denmark. In Alcohol Alcohol, 20 Nov 2014
AIMS: The aim of the present study was to investigate whether there are differences in plasma levels of YKL-40 between Inuit in Greenland and in Denmark and in Danes, as well as to study the relationship between alcohol intake, plasma YKL-40 and other factors in Inuit.
Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.
New
Kastrup et al., Copenhagen, Denmark. In Biomark Med, Aug 2014
AIM: The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD).
Adult asthma biomarkers.
Review
New
Park et al., Suwŏn, South Korea. In Curr Opin Allergy Clin Immunol, Feb 2014
YKL-40 is associated with asthma severity and airway remodeling.
Expression of CHI3L1 and CHIT1 in osteoarthritic rat cartilage model. A morphological study.
New
Musumeci et al., Catania, Italy. In Eur J Histochem, Dec 2013
In recent years the biological role of chitinases has been studied in relation to different inflammatory diseases and more in particular the elevated levels of human cartilage glycoprotein 39 (CHI3L1) and chitotriosidase (CHIT1) have been reported in a variety of diseases including chronic inflammation and degenerative disorders.
Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis.
Review
New
Kzhyshkowska et al., Mannheim, Germany. In Front Physiol, Dec 2013
New pro-angiogenic factor YKL-40 belongs to a family of mammalian chitinase-like proteins (CLP) that act as cytokines or growth factors.
Applications and limitations of inflammatory biomarkers for studies on neurocognitive impairment in HIV infection.
Review
New
Gabuzda et al., Boston, United States. In J Neuroimmune Pharmacol, Dec 2013
As an example for using this analytic pipeline, we present an exploratory study of 22 plasma inflammatory biomarkers (IFN-α 2b and -γ, 16 cytokines/chemokines, sIL-2R, sCD14, HA, and YKL-40) in a cohort of HIV-infected individuals with advanced disease, frequent HCV co-infection, and viral suppression on ART.
Unveiling YKL-40, from Serum Marker to Target Therapy in Glioblastoma.
Review
New
Hormigo et al., New York City, United States. In Front Oncol, Dec 2013
We review the current concept of developing YKL-40 as one of the most promising serum markers for glioblastoma, the recent advances on understanding the role of YKL-40 in gliomagenesis, and the promising evidence emerging from preclinical models on using this protein as a target for anti-glioma therapy.
Running a marathon induces changes in adipokine levels and in markers of cartilage degradation - novel role for resistin.
New
Moilanen et al., Tampere, Finland. In Plos One, Dec 2013
We measured levels of matrix metalloproteinase-3 (MMP-3), cartilage oligomeric protein (COMP) and chitinase 3-like protein 1 (YKL-40) as biomarkers of cartilage turnover and/or damage and plasma concentrations of adipokines adiponectin, leptin and resistin.
Potential biomarkers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease.
Review
Wan Ahmad et al., Kuala Lumpur, Malaysia. In Int J Endocrinol, 2012
This review examines potential biological markers, YKL-40, alpha-hydroxybutyrate, soluble CD36, leptin, resistin, interleukin-18, retinol binding protein-4, and chemerin, as they may play significant roles in insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease.
Promoter polymorphisms in CHI3L1 are associated with asthma.
GeneRIF
Sinnett et al., In J Allergy Clin Immunol, 2012
rs4950928 and rs10399931 promoter polymorphisms in CHI3L1 are equally likely to modulate CHI3L1 expression and susceptibility to asthma in Caucasian and African populations.
Extent of tumor removal and molecular markers in cerebral glioblastoma: a combined prognostic factors study in a surgical series of 105 patients.
GeneRIF
Santoro et al., Roma, Italy. In J Neurosurg, 2012
When biological aggressiveness is taken into account, YKL-40 expression was found to be an independent prognostic factor that predicts OS better than MGMT status.
Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease.
GeneRIF
Park et al., Iksan, South Korea. In Cytokine, 2012
Serum YKL-40 levels are highest during pneumonia compared to common pulmonary/pleural diseases and are more useful for monitoring pneumonia than asthma
YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes.
GeneRIF
Schernthaner et al., Zürich, Switzerland. In Atherosclerosis, 2012
YKL-40 is higher in subjects with peripheral arterial disease. YKL-40 was higher in PAD patients with pre-/diabetes.
Involvement of the MAPK and PI3K pathways in chitinase 3-like 1-regulated hyperoxia-induced airway epithelial cell death.
GeneRIF
Sohn et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
This study indicates that CHI3L1 is involved in hyperoxia-induced cell death, suggesting that CHI3L1 may be one of several cell death regulators influencing the MAPK and PI3K pathways during oxidative stress in human airway epithelial cells.
Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population.
Impact
Nordestgaard et al., Copenhagen, Denmark. In J Clin Oncol, 2009
PURPOSE: Elevated plasma YKL-40 is a biomarker of poor prognosis in cancer patients.
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Impact
GeneRIF
Chupp et al., Chicago, United States. In N Engl J Med, 2008
CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.
A chitinase-like protein in the lung and circulation of patients with severe asthma.
Impact
Elias et al., New Haven, United States. In N Engl J Med, 2007
The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum.
Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma.
Impact
Aldape et al., Houston, United States. In J Clin Oncol, 2007
These data were then examined in conjunction with the expression of phospho-intermediates (in a subset of these patients) of downstream AKT and Ras pathways and YKL-40 as well as with known clinical risk factors, including the Radiation Therapy Oncology Group's recursive partitioning analysis (RTOG-RPA) class.
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