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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 18 Nov 2014.

Chitinase 3-like 1

YKL-40, CHI3L1, HC gp-39, cartilage glycoprotein-39
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Chitinase, HAD, CD45, AGE, CAN
Papers on YKL-40
Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model.
New
Zhi et al., Guangzhou, China. In World J Gastroenterol, 14 Dec 2014
AIM: To investigate the possible role of chitinase 3-like-1 (CHI3L1) in the progression of colitis-associated carcinoma (CAC).
Effect of Melatonin on Human Nighttime Endotoxaemia: Randomized, Double-blinded, Cross-over Study.
New
Gögenur et al., Copenhagen, Denmark. In In Vivo, 12 Dec 2014
Blood samples were drawn before and 2, 4, 6 and 8 h after induction of endotoxaemia and plasma was tested for pro-inflammatory markers (tumor necrosis factor alpha, TNF-α, interleukin-1β, IL-1β, interleukin-1, IL-6, and YKL-40), anti-inflammatory markers (interleukin-1 receptor antagonist, IL-1Ra, interleukin-10, IL-10, soluble tumor necrosis factor receptors I and II, sTNF-RI and sTNF-RII), marker for oxidative damage (malondialdehyde (MDA)) and antioxidative enzyme (ascorbic acid (AA) and dehydroascorbic acid (DHA)).
Role for mammalian chitinase 3-like protein 1 in traumatic brain injury.
New
Kochanek et al., Pittsburgh, United States. In Neuropathology, 07 Dec 2014
We recently observed prominent astrocytic expression of YKL-40/chitinase 3-like protein 1 (CHI3L1) associated with severity of brain injury.
The significance of YKL-40 protein in liver fibrosis.
Review
New
Li et al., Hefei, China. In Inflamm Res, Apr 2014
OBJECTIVE: The aims of this review are to describe the present knowledge about YKL-40 protein, discuss its relation to liver fibrosis, and to look ahead at future perspectives of YKL-40 research.
Adult asthma biomarkers.
Review
New
Park et al., Suwŏn, South Korea. In Curr Opin Allergy Clin Immunol, Feb 2014
YKL-40 is associated with asthma severity and airway remodeling.
YKL-40, a Marker of Cardiovascular Disease and Endothelial Dysfunction, in Kidney Transplant Recipients.
New
Malyszko et al., Białystok, Poland. In Transplant Proc, Dec 2013
BACKGROUND: YKL-40 is an inflammatory glycoprotein involved in endothelial dysfunction and expressed in macrophages in the earliest lesion of atherosclerosis.
Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis.
Review
New
Kzhyshkowska et al., Mannheim, Germany. In Front Physiol, Dec 2013
New pro-angiogenic factor YKL-40 belongs to a family of mammalian chitinase-like proteins (CLP) that act as cytokines or growth factors.
Unveiling YKL-40, from Serum Marker to Target Therapy in Glioblastoma.
Review
New
Hormigo et al., New York City, United States. In Front Oncol, Dec 2013
We review the current concept of developing YKL-40 as one of the most promising serum markers for glioblastoma, the recent advances on understanding the role of YKL-40 in gliomagenesis, and the promising evidence emerging from preclinical models on using this protein as a target for anti-glioma therapy.
YKL-40, a Novel Marker of Cardiovascular Complications, Is Related to Kidney Function in Heart Transplant Recipients.
New
Małyszko et al., Kraków, Poland. In Transplant Proc, Dec 2013
BACKGROUND: YKL-40 is an inflammatory glycoprotein involved in endothelial dysfunction and expressed in macrophages in the earliest lesions of atherosclerosis.
Potential biomarkers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease.
Review
Wan Ahmad et al., Kuala Lumpur, Malaysia. In Int J Endocrinol, 2012
This review examines potential biological markers, YKL-40, alpha-hydroxybutyrate, soluble CD36, leptin, resistin, interleukin-18, retinol binding protein-4, and chemerin, as they may play significant roles in insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease.
Promoter polymorphisms in CHI3L1 are associated with asthma.
GeneRIF
Sinnett et al., In J Allergy Clin Immunol, 2012
rs4950928 and rs10399931 promoter polymorphisms in CHI3L1 are equally likely to modulate CHI3L1 expression and susceptibility to asthma in Caucasian and African populations.
Extent of tumor removal and molecular markers in cerebral glioblastoma: a combined prognostic factors study in a surgical series of 105 patients.
GeneRIF
Santoro et al., Roma, Italy. In J Neurosurg, 2012
When biological aggressiveness is taken into account, YKL-40 expression was found to be an independent prognostic factor that predicts OS better than MGMT status.
Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease.
GeneRIF
Park et al., Iksan, South Korea. In Cytokine, 2012
Serum YKL-40 levels are highest during pneumonia compared to common pulmonary/pleural diseases and are more useful for monitoring pneumonia than asthma
YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes.
GeneRIF
Schernthaner et al., Zürich, Switzerland. In Atherosclerosis, 2012
YKL-40 is higher in subjects with peripheral arterial disease. YKL-40 was higher in PAD patients with pre-/diabetes.
Involvement of the MAPK and PI3K pathways in chitinase 3-like 1-regulated hyperoxia-induced airway epithelial cell death.
GeneRIF
Sohn et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
This study indicates that CHI3L1 is involved in hyperoxia-induced cell death, suggesting that CHI3L1 may be one of several cell death regulators influencing the MAPK and PI3K pathways during oxidative stress in human airway epithelial cells.
Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population.
Impact
Nordestgaard et al., Copenhagen, Denmark. In J Clin Oncol, 2009
PURPOSE: Elevated plasma YKL-40 is a biomarker of poor prognosis in cancer patients.
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Impact
GeneRIF
Chupp et al., Chicago, United States. In N Engl J Med, 2008
CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.
A chitinase-like protein in the lung and circulation of patients with severe asthma.
Impact
Elias et al., New Haven, United States. In N Engl J Med, 2007
The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum.
Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma.
Impact
Aldape et al., Houston, United States. In J Clin Oncol, 2007
These data were then examined in conjunction with the expression of phospho-intermediates (in a subset of these patients) of downstream AKT and Ras pathways and YKL-40 as well as with known clinical risk factors, including the Radiation Therapy Oncology Group's recursive partitioning analysis (RTOG-RPA) class.
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