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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Glutathione S-transferase A3

YC-1, SCR2
may play a role in drug resistance and carcinogenesis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, CAN, HIF-1alpha, HAD, ACID
Papers on YC-1
Functional conservation of rice OsNF-YB/YC and Arabidopsis AtNF-YB/YC proteins in the regulation of flowering time.
New
Kim et al., Seoul, South Korea. In Plant Cell Rep, Feb 2016
In Arabidopsis thaliana, two NF-YB (AtNF-YB2 and AtNF-YB3) and five NF-YC (AtNF-YC1, AtNF-YC2, AtNF-YC3, AtNF-YC4, and AtNF-YC9) genes regulate photoperiodic flowering by interacting with other AtNF-Y subunit proteins.
Hypoxia promotes apoptosis of neuronal cells through hypoxia-inducible factor-1α-microRNA-204-B-cell lymphoma-2 pathway.
New
Qiao et al., China. In Exp Biol Med (maywood), Jan 2016
HIF-1α inhibitor YC-1 and siHIF-1α were employed to determine the effect of HIF-1α on the up-regulation of miR-204 and down-regulation of BCL-2 induced by hypoxia.
Stabilization of HIF-1α by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury.
New
Zhang et al., Wenzhou, China. In Brain Res, Jan 2016
Combination therapy including the specific HIF-1α blocker YC-1 down-regulated the HIF-1α expression and partially abolished the protective effect of FG-4592.
The ability of a cold-adapted Rhodotorula mucilaginosa strain from Tibet to control blue mold in pear fruit.
New
Zheng et al., Hangzhou, China. In Antonie Van Leeuwenhoek, Dec 2015
YC1, an isolate identified as Rhodotorula mucilaginosa, was found to exhibit the greatest biocontrol activity among the different isolates that were screened.
Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae.
New
Wei et al., South Bend, United States. In Biotechnol Biofuels, Dec 2015
RESULTS: We recently developed a yeast strain YC1 with superior resistance to acetic acid, furfural, and their mixture through inverse metabolic engineering.
YC-1 induces lipid droplet formation in RAW 264.7 macrophages.
New
Wang et al., Taipei, Taiwan. In J Biomed Sci, Dec 2015
BACKGROUND: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) is a potential anticancer drug that may activate soluble guanylyl cyclase (sGC) and increase the level of cyclic guanosine monophosphate (cGMP).
Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis.
New
Liu et al., Augusta, United States. In Oncotarget, Dec 2015
Inhibition of HIF-1α signaling by using RNAi or YC-1, a specific inhibitor of HIF-1α synthesis, both completely diminished mRNA level of VEGF and greatly inhibited endothelial cell proliferation promoted by HER2+ tumor cell-conditioned medium in both the absence and presence of HRG-β1 pretreatment.
Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species-mediated B-cell lymphoma extra-long pathway in glioblastoma multiforme.
Hsieh et al., Taiwan. In J Transl Med, 2014
Tempol, YC-1 (HIF-1 inhibitor), and Bay 11-7082 (NF-κB inhibitor) suppressed the cycling hypoxia-mediated Bcl-xL induction in vitro and in vivo.
Interlinking of hypoxia and estrogen in thyroid cancer progression.
Review
Tiwari et al., Valhalla, United States. In Curr Med Chem, 2013
In a series of experimentations, using human thyroid cancer cells, we observed that estrogen and hypoxia modulate the hypoxia inducible factor-1 (HIF-1) signaling which is abrogated by the anti-estrogen fulvestrant and the HIF-1 inhibitor YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole).
Soluble guanylate cyclase stimulators in pulmonary hypertension.
Review
Evgenov et al., Wuppertal, Germany. In Handb Exp Pharmacol, 2012
Optimisation of the first sGC stimulator, YC-1, led to the development of the more potent and more specific sGC stimulators, BAY 41-2272, BAY 41-8543 and riociguat (BAY 63-2521).
Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II.
Review
Czyz et al., Łódź, Poland. In Arch Immunol Ther Exp (warsz), 2011
topotecan, heat shock protein 90 and mTOR inhibitors, YC-1, pleurotin or 2-methoxyestradiol), which are being subjected into intensive investigation in clinical trials.
Guanylate cyclase activators, cell volume changes and IOP reduction.
Review
Ellis, Gainesville, United States. In Cell Physiol Biochem, 2010
Members of the membrane guanylate cyclase family of receptors bind to peptide ligands, while the sGC responds to gases (such as NO and CO(2)) and compounds (such as YC1, [3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole), a benzyl indazole derivative, and BAY-58-2667); activation of either results in formation of cyclic GMP (cGMP) and activation of protein kinase G (PKG) and subsequent phosphorylation of target proteins, including the high conductance calcium activated potassium channel (BKca channel).
Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation.
Review
Kitagawa et al., Hyderābād, India. In Biochem Biophys Res Commun, 2010
Carbon monoxide, along with some activator molecules like YC-1 and BAY, also synergistically activate sGC.
Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope.
GeneRIF
Ricci et al., Roma, Italy. In J Biol Chem, 2007
a considerable amount of GSTs, in particular GSTA1-1, GSTA2-2, and GSTA3-3, corresponding to 10% of the cytosolic pool is electrostatically associated with the outer nuclear membrane, and a similar quantity is compartmentalized inside the nucleus
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential.
Review
Impact
Stasch et al., Boston, United States. In Nat Rev Drug Discov, 2006
Here we review the discovery, biochemistry, pharmacology and clinical potential of haem-dependent sGC stimulators (including YC-1, BAY 41-2272, BAY 41-8543, CFM-1571 and A-350619) and haem-independent sGC activators (including BAY 58-2667 and HMR-1766).
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