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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Y box binding protein 1

YB-1, DbpB
transcription factor; acts as a regulator of protein tyrosine phosphatase PTP1B expression [RGD, Apr 2006] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, GST
Papers using YB-1 antibodies
Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation
Supplier
Rodemann H Peter et al., In Breast Cancer Research : BCR, 2009
... , as well as a nontargeting siRNA, were purchased from Thermo Scientific (Karlsruhe, Germany).YB-1-siRNA (siRNA-I/II) was purchased from Cell Signaling Technology ...
Papers on YB-1
YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.
New
Kenney et al., Atlanta, United States. In Oncogene, Feb 2016
We report that Y-box binding protein-1 (YB-1), an onco-protein regulating transcription and translation, binds to IGF2 promoter P3.
Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism.
New
Di Renzo et al., Torino, Italy. In Oncotarget, Dec 2015
Reduced endogenous FN deposition and TGF-β1 secretion depended on the lack of activating phosphorylation of the transcription/translation factor YB-1 by p90RSK.
Obligate anaerobic Salmonella typhimurium strain YB1 treatment on xenograft tumor in immunocompetent mouse model.
New
Qu et al., Shenzhen, China. In Oncol Lett, Aug 2015
In the present study, inoculation of the Salmonella strain, YB1, into a colon cancer tumor-bearing immunocompetent mouse model was investigated.
Transcriptional Regulation of the p16 Tumor Suppressor Gene.
Review
New
Okamoto et al., Fukuoka, Japan. In Anticancer Res, Aug 2015
YB1, a transcription factor, also represses the p16 transcription through direct association with its promoter region.
[Correlation of Twist and YB-1 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma].
New
Yang et al., Shenzhen, China. In Zhonghua Bing Li Xue Za Zhi, Aug 2015
OBJECTIVE: To investigate the clinicopathological significance of Twist and YB-1 up-regulation in cervical cancer, and to correlate the expression of the two genes with E-cadherin, a marker of epithelial-mesenchymal transition (EMT).
Transcription factors that interact with p53 and Mdm2.
Review
New
Frazier et al., Winston-Salem, United States. In Int J Cancer, Aug 2015
In this review, we focus on transcription factors that directly interact with p53/Mdm2 through direct binding including Dmp1, E2F1, YB-1 and YY1.
Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.
New
Impact
Sorensen et al., Vancouver, Canada. In Cancer Cell, Jun 2015
Previous research identified a crucial role for YB-1 in the epithelial-to-mesenchymal transition (EMT) and metastasis of epithelial malignancies.
Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy.
Riedel et al., Ulm, Germany. In Microb Cell Fact, 2014
Upon incubation with HT-29 MCTS, Bifidobacterium bifidum S17 and Salmonella typhimurium YB1 selectively localized, survived and replicated in hypoxic areas inside MCTS.
Y-box binding protein 1--a prognostic marker and target in tumour therapy.
Review
Schittek et al., Tübingen, Germany. In Eur J Cell Biol, 2014
Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular processes including both transcriptional and translational regulation of target gene expression.
YB-1 protein: functions and regulation.
Review
Ovchinnikov et al., Moscow, Russia. In Wiley Interdiscip Rev Rna, 2014
The Y-box binding protein 1 (YB-1, YBX1) is a member of the family of DNA- and RNA-binding proteins with an evolutionarily ancient and conserved cold shock domain.
New prognostic factors in breast cancer.
Review
Adam Maciejczyk, In Adv Clin Exp Med, 2013
This article shows the prognostic value of additional parameters, whose expression is associated with chemioresistance (MRP2, BCRP, YB1) or individual assessment of the dynamics of tumor progression (S100P, BUBR1).
The p63 protein isoform ΔNp63α modulates Y-box binding protein 1 in its subcellular distribution and regulation of cell survival and motility genes.
GeneRIF
Calabrò et al., Napoli, Italy. In J Biol Chem, 2012
DeltaNp63alpha affects cell movement and can reverse the increase of cell motility induced by YB-1 overexpression.
Y-box binding protein 1 and RNase UK114 mediate monocyte chemoattractant protein 1 mRNA stability in vascular smooth muscle cells.
GeneRIF
Taubman et al., Rochester, United States. In Mol Cell Biol, 2012
These studies define new roles for glucocorticoid receptor, Y-box binding protein 1, and RNase UK114 in the formation of a molecular complex that degrades MCP-1 mRNA.
Elevated nuclear YB1 expression is associated with poor survival of patients with early breast cancer.
GeneRIF
Surowiak et al., Wrocław, Poland. In Anticancer Res, 2012
Patients with a pronounced expression of the nuclear form the YB1 protein demonstrated a significant shortening of disease-free survival, disease-specific survival and overall survival
Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.
GeneRIF
Dunn et al., Vancouver, Canada. In Stem Cells, 2012
Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.
Y-box binding protein-1 implicated in translational control of fetal myocardial gene expression after cardiac transplant.
GeneRIF
Strauch et al., Columbus, United States. In Exp Biol Med (maywood), 2012
findings show heterotopic cardiac transplant resulted in accumulation of 50-kDa YB-1 polypeptide within the polyribosome-enriched cytosol proximal to cardiac intercalated discs; YB-1 may govern cell response in the transplanted heart through its ability to bind and protect injury-activated mRNA transcripts that are prioritized for translation to assure graft adaptation
Y-box-binding protein YB-1 identifies high-risk patients with primary breast cancer benefiting from rapidly cycled tandem high-dose adjuvant chemotherapy.
Impact
GeneRIF
Harbeck et al., Köln, Germany. In J Clin Oncol, 2010
Y-box-binding protein YB-1, a multifunctional protein, is linked to tumor aggressiveness and multidrug resistance.
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.
Impact
Hughes et al., Toronto, Canada. In Nat Biotechnol, 2009
We tested RNAcompete by analyzing nine diverse RBPs (HuR, Vts1, FUSIP1, PTB, U1A, SF2/ASF, SLM2, RBM4 and YB1).
YB-1 translational control of epithelial-mesenchyme transition.
Impact
Brugge et al., Boston, United States. In Cancer Cell, 2009
In this issue of Cancer Cell, Evdokimova et al. demonstrate that YB-1 regulates epithelial-mesenchyme transition (EMT) by inducing cap-independent translation of mRNAs encoding EMT-promoting factors and suppressing cap-dependent translation of mRNAs encoding growth-promoting factors.
Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition.
Impact
GeneRIF
Sorensen et al., Vancouver, Canada. In Cancer Cell, 2009
translational regulation by YB-1 is a restriction point enabling coordinated expression of a network of epithelial-mesenchymal transition-inducing transcription factors, likely acting together to promote metastatic spread
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