Current Therapeutic Options in Sturge-Weber Syndrome.
Baltimore, United States. In Semin Pediatr Neurol, Dec 2015
The mutation results in constitutive overactivation of the Ras-Raf-MEK-ERK and the HIPPO-YAP pathways and inhibitors of these pathways may in the future prove useful in the treatment of Sturge-Weber syndrome.
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.
Shanghai, China. In Cell, Dec 2015
By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status.
YAP and TAZ Take Center Stage in Cancer.
Tianjin, China. In Biochemistry, Dec 2015
In the Hippo pathway, MST1/2 and LATS1/2 regulate downstream transcription coactivators YAP and TAZ, which mainly interact with TEAD family transcription factors to promote tissue proliferation, self-renewal of normal and cancer stem cells, migration, and carcinogenesis.
Alternative Wnt Signaling Activates YAP/TAZ.
San Diego, United States. In Cell, Sep 2015
The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer.
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
Leuven, Belgium. In Nat Rev Mol Cell Biol, 2012
Studies indicate that the transcriptional co-activators YAP and TAZ recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM) elasticity and cell shape.