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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

YAP1 Yap1p

YAP, Yap1, Yap1p
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TAZ, CAN, V1a, MSP, HAD
Papers on YAP
Sequence Kernel Association Test of Multiple Continuous Phenotypes.
New
Pankow et al., Minneapolis, United States. In Genet Epidemiol, Feb 2016
We identified an exome-wide significant rare variant set in the gene YAP1 worthy of further investigations.
Human pluripotent stem cell culture density modulates YAP signaling.
New
Palecek et al., Madison, United States. In Biotechnol J, Feb 2016
To probe regulation of Hippo pathway activity in hPSCs, we assessed whether Hippo pathway transcriptional activator YAP was differentially modulated by cell density.
RASSF1A suppresses the invasion and metastatic potential of human non-small cell lung cancer cells by inhibiting YAP activation through the GEF-H1/RhoB pathway.
New
Zalcman et al., Caen, France. In Cancer Res, Feb 2016
Further, RASSF1A reduced nuclear accumulation of the Hippo pathway transcriptional co-factor YAP, which was unaffected by MST1 (Hippo) or LATS1 but reinforced by RhoB activation.
Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells.
New
He et al., Hangzhou, China. In Oncotarget, Feb 2016
In the present study, we found that hypoxia-induced nuclear translocation and accumulation of YAP acted as a survival input to promote resistance to SN38 in HCC.
The Hippo pathway as drug targets in cancer therapy and regenerative medicine.
New
Hata et al., Tokyo, Japan. In Curr Drug Targets, Feb 2016
UNASSIGNED: Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ) co-operate with numerous transcription factors to regulate gene transcriptions.
Hippo pathway and breast cancer stem cells.
Review
New
De Maria et al., Roma, Italy. In Crit Rev Oncol Hematol, Jan 2016
Altered Hippo activity, or Hippo-independent mechanisms, mediate the activation of the Hippo transducers TAZ and YAP.
A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.
New
Impact
Eilers et al., W├╝rzburg, Germany. In Cancer Cell, Jan 2016
This change in gene expression indirectly inhibits the YAP/TAZ co-activators, which maintain the clonogenic potential of these cells.
Current Therapeutic Options in Sturge-Weber Syndrome.
Review
New
Comi, Baltimore, United States. In Semin Pediatr Neurol, Dec 2015
The mutation results in constitutive overactivation of the Ras-Raf-MEK-ERK and the HIPPO-YAP pathways and inhibitors of these pathways may in the future prove useful in the treatment of Sturge-Weber syndrome.
Experimental Model for Successful Liver Cell Therapy by Lenti TTR-YapERT2 Transduced Hepatocytes with Tamoxifen Control of Yap Subcellular Location.
New
Shafritz et al., Singapore, Singapore. In Sci Rep, Dec 2015
Thus, we have developed the first vector designed to regulate the growth control properties of Yap that renders it capable of producing effective cell therapy.
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.
Review
New
Impact
Guan et al., Shanghai, China. In Cell, Dec 2015
By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status.
YAP and TAZ Take Center Stage in Cancer.
Review
New
Hong et al., Tianjin, China. In Biochemistry, Dec 2015
In the Hippo pathway, MST1/2 and LATS1/2 regulate downstream transcription coactivators YAP and TAZ, which mainly interact with TEAD family transcription factors to promote tissue proliferation, self-renewal of normal and cancer stem cells, migration, and carcinogenesis.
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction.
Review
New
Dupont, Padova, Italy. In Exp Cell Res, Nov 2015
We here discuss recent advances on how mechanical signals intersect nuclear transcription and in particular the activity of YAP/TAZ transcriptional coactivators, known downstream transducers of the Hippo pathway and important effectors of ECM mechanical cues.
Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.
New
Impact
Wrana et al., Toronto, Canada. In Nature, Nov 2015
Here we demonstrate in mice that Yap, a downstream transcriptional effector of Hippo, is critical for recovery of intestinal epithelium after exposure to ionizing radiation.
Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance.
New
Impact
Lo et al., Los Angeles, United States. In Cell, Oct 2015
We identified in the tumor cell compartment supra-physiologic c-MET up-expression, infra-physiologic LEF1 down-expression and YAP1 signature enrichment as drivers of acquired resistance.
Alternative Wnt Signaling Activates YAP/TAZ.
New
Impact
Guan et al., San Diego, United States. In Cell, Sep 2015
The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer.
YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway.
GeneRIF
Yu et al., Taipei, Taiwan. In Exp Cell Res, 2012
Expression of Yap activated Shh but not Wnt or Notch signaling activity during neuronal differentiation.
PTPN14 is required for the density-dependent control of YAP1.
GeneRIF
Chen et al., Houston, United States. In Genes Dev, 2012
that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
Impact
GeneRIF
Piccolo et al., Leuven, Belgium. In Nat Rev Mol Cell Biol, 2012
Studies indicate that the transcriptional co-activators YAP and TAZ recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM) elasticity and cell shape.
Yes-associated protein is not an independent prognostic marker in breast cancer.
GeneRIF
Tang et al., Kao-hsiung, Taiwan. In Anticancer Res, 2012
YAP expression failed to produce any significant relationship with the overall survival rate. CONCLUSION: YAP expression is not an independent prognostic factor in patients with breast cancer.
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.
GeneRIF
Pan et al., United States. In Genes Dev, 2012
These findings provide proof of principle that inhibiting TEAD-YAP interactions is a pharmacologically viable strategy against the YAP oncoprotein.
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