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YY1 associated factor 2

YAF2, YY1-associated factor 2
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: YY1, RYBP, RING finger protein, CAN, Polycomb
Papers on YAF2
Cellular functions of programmed cell death 5.
Chen et al., Beijing, China. In Biochim Biophys Acta, Feb 2016
The stability and expression of PDCD5 are finely regulated by other molecules, such as NF-κB p65, OTUD5, YAF2 and DNAJB1.
YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5.
Yoon et al., Seoul, South Korea. In Biochim Biophys Acta, May 2015
We identified YY1-associated factor 2 (YAF2) as a novel PDCD5-interacting protein in a yeast two-hybrid screen for PDCD5-interacting proteins.
YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment.
Atchison et al., Philadelphia, United States. In Nucleic Acids Res, 2014
YY1 also physically interacts with YAF2, a homolog of RYBP.
miR-411 is up-regulated in FSHD myoblasts and suppresses myogenic factors.
Chen et al., Washington, D.C., United States. In Orphanet J Rare Dis, 2012
By analyzing both miRNA and mRNA data using Partek Genomics Suite, we identified 4 mRNAs potentially regulated by miR-411 including YY1 associated factor 2 (YAF2).
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.
Reinberg et al., New York City, United States. In Mol Cell, 2012
Further biochemical dissection revealed that the six PCGF-RING1A/B combinations form multiple complexes through association with RYBP or its homolog YAF2, which prevents the incorporation of other canonical PRC1 subunits, such as CBX, PHC, and SCM.
Association of Rex-1 to target genes supports its interaction with Polycomb function.
Schoorlemmer et al., Zaragoza, Spain. In Stem Cell Res, 2011
To substantiate the hypothesis that Rex-1 contributes to gene regulation by PcG, we demonstrate interactions of Rex-1 and YY2 (a close relative of YY1) with Ring1 proteins and the PcG-associated proteins RYBP and YAF2, in line with interactions reported previously for YY1.
PcG recruitment by the YY1 REPO domain can be mediated by Yaf2.
Atchison et al., Philadelphia, United States. In J Cell Biochem, 2010
Yaf2 acts as a functional, likely molecular, link between YY1 and the Polycomb proteins. It is proposed to mediate the DNA binding activity of YY1 and recruitment of Polycomb proteins to the regulatory region of target genes.
Isolation and characterization of nontubular sca-1+lin- multipotent stem/progenitor cells from adult mouse kidney.
Reisner et al., Israel. In J Am Soc Nephrol, 2006
Global gene profiling reveals enrichment for many genes downstream of developmental signaling molecules and self-renewal pathways, such as TGF-beta/bone morphogenic protein, Wnt, or fibroblast growth factor, as well as for those that are involved in specification of mesodermal lineages (myocyte enhancer factor 2A, YY1-associated factor 2, and filamin-beta).
Yaf2 inhibits caspase 8-mediated apoptosis and regulates cell survival during zebrafish embryogenesis.
Schreiber-Agus et al., New York City, United States. In J Biol Chem, 2006
Yaf2 and Rybp can encode opposing functions in the regulation of apoptosis
Phenotype-genotype correlation in two patients with 12q proximal deletion.
Matsumoto et al., Nagasaki, Japan. In J Hum Genet, 2003
Among them, YAF2 and AMIGO2 were the most plausible candidates to affect growth and psychomotor retardation, respectively, in both cases.
The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos.
Koseki et al., Chiba, Japan. In Gene, 2003
We isolated mouse YAF2 as a protein that interacts with Ring1B, a known constituent of mammalian PcG complexes.
YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.
Handa et al., Yokohama, Japan. In J Biol Chem, 2002
YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.
The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm.
Lenardo et al., Bethesda, United States. In J Biol Chem, 2001
DEDAF is highly conserved between human and mouse (98% amino acid identity) and is homologous to a nuclear regulatory protein YAF-2.
Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1.
Lee et al., Buffalo, United States. In Nucleic Acids Res, 1997
We report the isolation and characterization of a novel protein termed YAF2 (YY1- associated factor 2) that interacts with YY1.
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