APOH interacts with FTO to predispose to healthy thinness.
Salt Lake City, United States. In Hum Genet, Feb 2016
For validation, we tested the candidates for association with healthy thinness in additional pedigree members while accounting for effects of obesity-associated genes: NPFFR2, NPY2R, FTO, and MC4R.
Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors.
Lund, Sweden. In Neurobiol Dis, Feb 2016
In the present study, a conceptually novel framework reflecting a plausible clinical trial for gene therapy of temporal lobe epilepsy was explored: We investigated (i) whether the post intrahippocampal kainate-induced status epilepticus (SE) model of chronic epilepsy in rats could be clinically relevant; and (ii) whether a translationally designed neuropeptide Y (NPY)/Y2 receptor-based gene therapy approach targeting only the seizure-generating focus unilaterally can decrease seizure frequency in this chronic model of epilepsy.
The role of NPY in learning and memory.
Copenhagen, Denmark. In Neuropeptides, Nov 2015
In addition, NPY impairs acquisition but enhances consolidation and retention in models depending on spatial and discriminative types of associative explicit memory, presumably involving Y2 receptor-mediated regulations of hippocampal excitatory transmission.
Neuropeptide Y: A stressful review.
Graz, Austria. In Neuropeptides, Oct 2015
The biological actions of NPY in mammals are mediated by the Y1, Y2, Y4 and Y5 receptors, Y1 receptor stimulation being anxiolytic whereas Y2 receptor activation is anxiogenic.
Ligands of the neuropeptide Y Y2 receptor.
Los Angeles, United States. In Bioorg Med Chem Lett, 2014
Y2 receptor is the most abundant Y subtype receptor in the central nervous system and implicated with food intake, bone formation, affective disorders, alcohol and drugs of abuse, epilepsy, pain, and cancer.
Bethesda, United States. In Unknown Journal, 2012
One of these antagonists, Y1-973, is reported to have IC50 values of 0.13 nM for human NPY1R and >10,000 nM for human NPY2R, NPY4R, and NPY5R.