mRNA quality control goes transcriptional.
Oxford, United Kingdom. In Biochem Soc Trans, Dec 2013
Nucleases including Xrn2/Rat1 and the nuclear exosome have been shown to play an important role in the turnover of aberrant mRNAs.
Gene expression signatures of primary and metastatic uterine leiomyosarcoma.
Oslo, Norway. In Hum Pathol, Dec 2013
Genes overexpressed in primary uterine LMSs included OSTN, NLGN4X, NLGN1, SLITRK4, MASP1, XRN2, ASS1, RORB, HRASLS, and TSPAN7.
The multifunctional RNase XRN2.
Basel, Switzerland. In Biochem Soc Trans, Aug 2013
XRN2 is a 5'→3' exoribonuclease that is evolutionarily conserved in eukaryotes.
MicroRNAses and the regulated degradation of mature animal miRNAs.
Basel, Switzerland. In Adv Exp Med Biol, 2009
Initially thought to be very stable with half-lives on the order of days, mature miRNAs have recently been shown to be subject to degradation by 'microRNases' (miRNases) in plants (the small RNA degrading nucleases, SDN) and animals (exoribonuclease 2/XRN-2/XRN2).
Turnover of mature miRNAs and siRNAs in plants and algae.
Lincoln, United States. In Adv Exp Med Biol, 2009
Recent studies in Arabidopsis thaliana and Caenorhabditis elegans have implicated 3'-to-5' (SDNs) and 5'-to-3' (XRN-2) exoribonucleases in mature miRNA turnover and the modulation of small RNA levels and activity.
A ribonucleolytic rat torpedoes RNA polymerase II.
Aurora, United States. In Cell, 2005
Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2).