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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

5'-3' exoribonuclease 2

Xrn2
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: exoribonuclease, POLYMERASE, CAN, XRN1, caspase-3
Papers on Xrn2
Structural basis and function of XRN2 binding by XTB domains.
New
Großhans et al., Basel, Switzerland. In Nat Struct Mol Biol, Feb 2016
UNASSIGNED: The RNase XRN2 is essential in RNA metabolism.
P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.
New
Fisher et al., New York City, United States. In Genes Dev, Feb 2016
Among the RNA processing factors phosphorylated by Cdk9 was the 5'-to-3' "torpedo" exoribonuclease Xrn2, required in transcription termination by Pol II, which we validated as a bona fide P-TEFb substrate in vivo and in vitro.
Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.
New
Grewal et al., Bethesda, United States. In Proc Natl Acad Sci U S A, Jan 2016
Here we show that RNA elimination factors cooperate with the conserved exoribonuclease Dhp1/Rat1/Xrn2, which couples pre-mRNA 3'-end processing to transcription termination, to promote premature termination and facultative heterochromatin formation at meiotic genes.
Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5'-3' exoribonuclease) in the nucleoplasm.
New
Takahashi et al., Tokyo, Japan. In Nucleic Acids Res, Jan 2016
In this study, we demonstrate that CARF associates with 5'-3' exoribonuclease 2 (XRN2), which plays a major role in both the maturation of rRNA and the degradation of a variety of discarded pre-rRNA species.
Interaction of host cell microRNAs with the HCV RNA genome during infection of liver cells.
Review
New
Sarnow et al., Stanford, United States. In Semin Liver Dis, Feb 2015
In this review, the authors summarize the molecular mechanism by which miR-122 protects the HCV RNA genome from degradation by exoribonucleases Xrn1 and Xrn2 and discuss the application of miR-122 antisense molecules in the clinic.
The human decapping scavenger enzyme DcpS modulates microRNA turnover.
Simard et al., Québec, Canada. In Sci Rep, 2014
We also demonstrate that this new function for DcpS requires the contribution of the 5'-3' exonuclease Xrn2.
mRNA quality control goes transcriptional.
Review
Vasiljeva et al., Oxford, United Kingdom. In Biochem Soc Trans, 2013
Nucleases including Xrn2/Rat1 and the nuclear exosome have been shown to play an important role in the turnover of aberrant mRNAs.
The multifunctional RNase XRN2.
Review
Großhans et al., Basel, Switzerland. In Biochem Soc Trans, 2013
XRN2 is a 5'→3' exoribonuclease that is evolutionarily conserved in eukaryotes.
XRN 5'→3' exoribonucleases: structure, mechanisms and functions.
Review
Green et al., Newark, United States. In Biochim Biophys Acta, 2013
Highly conserved across species, the family is typically represented by one cytoplasmic enzyme (XRN1/PACMAN or XRN4) and one or more nuclear enzymes (XRN2/RAT1 and XRN3).
Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII.
Impact
GeneRIF
Kiernan et al., Montpellier, France. In Cell, 2012
Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR.
Co-transcriptional degradation of aberrant pre-mRNA by Xrn2.
GeneRIF
West et al., Edinburgh, United Kingdom. In Embo J, 2012
Xrn2 associated with and co-transcriptionally degraded nascent beta-globin transcripts. Evidence was provided that many endogenous pre-mRNAs are also co-transcriptionally degraded by Xrn2 when their processing is inhibited by Spliceostatin A.
mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription.
GeneRIF
Bentley et al., Aurora, United States. In Mol Cell, 2012
Xrn2 has a role in control of transcription by RNA polymerase II.
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
GeneRIF
Gromak et al., Oxford, United Kingdom. In Mol Cell, 2011
The results predict that senataxin is required for the resolution of R-loops formed downstream of the poly(A) signal, allowing Xrn2 recruitment and efficient Pol II transcriptional termination.
Arabidopsis thaliana XRN2 is required for primary cleavage in the pre-ribosomal RNA.
GeneRIF
Kufel et al., Warsaw, Poland. In Nucleic Acids Res, 2010
AtXRN2 has a role in ribosomal RNA processing.
MicroRNAses and the regulated degradation of mature animal miRNAs.
Review
Chatterjee et al., Basel, Switzerland. In Adv Exp Med Biol, 2009
Initially thought to be very stable with half-lives on the order of days, mature miRNAs have recently been shown to be subject to degradation by 'microRNases' (miRNases) in plants (the small RNA degrading nucleases, SDN) and animals (exoribonuclease 2/XRN-2/XRN2).
Active turnover modulates mature microRNA activity in Caenorhabditis elegans.
Impact
Grosshans et al., Basel, Switzerland. In Nature, 2009
Here we report that degradation of mature miRNAs in the nematode Caenorhabditis elegans, mediated by the 5'-->3' exoribonuclease XRN-2, affects functional miRNA homeostasis in vivo.
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.
Impact
Tong et al., New York City, United States. In Nature, 2009
XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14).
A ribonucleolytic rat torpedoes RNA polymerase II.
Impact
Bentley et al., Aurora, United States. In Cell, 2005
Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2).
Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.
Impact
GeneRIF
Proudfoot et al., Oxford, United Kingdom. In Nature, 2004
co-transcriptional cleavage acts as a precursor to termination by presenting a free RNA 5' end that is recognized by the human 5' --> 3' exonuclease Xrn2
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