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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Sep 2015.

5'-3' exoribonuclease 2

This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: exoribonuclease, POLYMERASE, CAN, XRN1, Cdc4
Papers on Xrn2
NF-κB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'→3' exoribonuclease 2 and negative elongation factor.
Nourbakhsh et al., Hannover, Germany. In Faseb J, 04 Oct 2015
In copurification studies, aa 421-429 is required for interactions between NKRF, 5'→3' exoribonuclease 2 (XRN2) and the negative elongation factor (NELF)-E in HeLa cells.
XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides.
Obika et al., Suita, Japan. In Biochem Biophys Res Commun, 21 Sep 2015
To better understand this degradation pathway, we depleted the expression of two major 5' to 3' exoribonucleases (XRNs), named XRN1 and XRN2, and analyzed the levels of 3' fragments of the target RNAs in vitro.
Reduced expression of the mouse ribosomal protein Rpl17 alters the diversity of mature ribosomes by enhancing production of shortened 5.8S rRNA.
Pestov et al., United States. In Rna, Jul 2015
The 5' exoribonuclease Xrn2 is involved in the generation of both 5.8S(C) and the canonical long form of 5.8S rRNA.
Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis.
Takahashi et al., Tokyo, Japan. In Nucleic Acids Res, Jul 2015
In addition, double knockdown of XRN2 and RRP1 revealed that RRP1 accelerated the site 2 cleavage of 47S, 45S and 41S pre-rRNAs.
Whole genome methylation analyses of schizophrenia patients before and after treatment.
Toncheva et al., Sofia, Bulgaria. In Biotechnol Biotechnol Equip, Jun 2014
We found significant differences in the methylation profiles between male schizophrenia patients with complete remission and control male pool before treatment (C16orf70, CST3, DDRGK1, FA2H, FLJ30058, MFSD2B, RFX4, UBE2J1, ZNF311) and male schizophrenia patients with complete remission and control male pool after treatment (AP1S3, C16orf59, KCNK15, LOC146336, MGC16384, XRN2) that potentially could be used as target genes for new therapeutic strategies as well as markers for good treatment response.
mRNA quality control goes transcriptional.
Vasiljeva et al., Oxford, United Kingdom. In Biochem Soc Trans, 2013
Nucleases including Xrn2/Rat1 and the nuclear exosome have been shown to play an important role in the turnover of aberrant mRNAs.
The multifunctional RNase XRN2.
Großhans et al., Basel, Switzerland. In Biochem Soc Trans, 2013
XRN2 is a 5'→3' exoribonuclease that is evolutionarily conserved in eukaryotes.
XRN 5'→3' exoribonucleases: structure, mechanisms and functions.
Green et al., Newark, United States. In Biochim Biophys Acta, 2013
Highly conserved across species, the family is typically represented by one cytoplasmic enzyme (XRN1/PACMAN or XRN4) and one or more nuclear enzymes (XRN2/RAT1 and XRN3).
Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII.
Kiernan et al., Montpellier, France. In Cell, 2012
Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR.
Co-transcriptional degradation of aberrant pre-mRNA by Xrn2.
West et al., Edinburgh, United Kingdom. In Embo J, 2012
Xrn2 associated with and co-transcriptionally degraded nascent beta-globin transcripts. Evidence was provided that many endogenous pre-mRNAs are also co-transcriptionally degraded by Xrn2 when their processing is inhibited by Spliceostatin A.
mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription.
Bentley et al., Aurora, United States. In Mol Cell, 2012
Xrn2 has a role in control of transcription by RNA polymerase II.
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
Gromak et al., Oxford, United Kingdom. In Mol Cell, 2011
The results predict that senataxin is required for the resolution of R-loops formed downstream of the poly(A) signal, allowing Xrn2 recruitment and efficient Pol II transcriptional termination.
Arabidopsis thaliana XRN2 is required for primary cleavage in the pre-ribosomal RNA.
Kufel et al., Warsaw, Poland. In Nucleic Acids Res, 2010
AtXRN2 has a role in ribosomal RNA processing.
MicroRNAses and the regulated degradation of mature animal miRNAs.
Chatterjee et al., Basel, Switzerland. In Adv Exp Med Biol, 2009
Initially thought to be very stable with half-lives on the order of days, mature miRNAs have recently been shown to be subject to degradation by 'microRNases' (miRNases) in plants (the small RNA degrading nucleases, SDN) and animals (exoribonuclease 2/XRN-2/XRN2).
Turnover of mature miRNAs and siRNAs in plants and algae.
Ibrahim et al., Lincoln, United States. In Adv Exp Med Biol, 2009
Recent studies in Arabidopsis thaliana and Caenorhabditis elegans have implicated 3'-to-5' (SDNs) and 5'-to-3' (XRN-2) exoribonucleases in mature miRNA turnover and the modulation of small RNA levels and activity.
Active turnover modulates mature microRNA activity in Caenorhabditis elegans.
Grosshans et al., Basel, Switzerland. In Nature, 2009
Here we report that degradation of mature miRNAs in the nematode Caenorhabditis elegans, mediated by the 5'-->3' exoribonuclease XRN-2, affects functional miRNA homeostasis in vivo.
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.
Tong et al., New York City, United States. In Nature, 2009
XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14).
A ribonucleolytic rat torpedoes RNA polymerase II.
Bentley et al., Aurora, United States. In Cell, 2005
Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2).
Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.
Proudfoot et al., Oxford, United Kingdom. In Nature, 2004
co-transcriptional cleavage acts as a precursor to termination by presenting a free RNA 5' end that is recognized by the human 5' --> 3' exonuclease Xrn2
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