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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

5'-3' exoribonuclease 2

Xrn2
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: exoribonuclease, POLYMERASE, CAN, Cdc4, caspase-3
Papers on Xrn2
The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA.
New
Watkins et al., In Rna, 30 Apr 2014
Interestingly, we show that the RNA surveillance factors XRN2 and MTR4 are also involved in A' cleavage in humans.
Gene expression signatures of primary and metastatic uterine leiomyosarcoma.
New
Wang et al., Oslo, Norway. In Hum Pathol, 30 Apr 2014
Genes overexpressed in primary uterine LMSs included OSTN, NLGN4X, NLGN1, SLITRK4, MASP1, XRN2, ASS1, RORB, HRASLS, and TSPAN7.
Intestinal epithelial barrier disruption through altered mucosal microRNA expression in HIV and SIV infections.
New
Dandekar et al., Davis, United States. In J Virol, 26 Apr 2014
This decrease coincided with an increase in 5'-3'-exoribonuclease 2 protein and alterations in DICER1 and Argonaute 2 expression.
Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis.
New
Skogsberg et al., Stockholm, Sweden. In Plos Genet, 28 Feb 2014
In early lesions, PPARG was identified as a specific master regulator of the PCL-responsive atherosclerosis TF-regulatory network, whereas in mature and advanced lesions, the specific master regulators were MLL5 and SRSF10/XRN2, respectively.
PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain.
New
Großhans et al., Basel, Switzerland. In Mol Cell, 23 Feb 2014
Targeted paxt-1 inactivation through TALEN-mediated genome editing reduces XRN2 levels, decreases miRNA turnover activity, and results in worm death, which can be averted by overexpressing xrn-2.
Engineering of a conditional allele reveals multiple roles of XRN2 in Caenorhabditis elegans development and substrate specificity in microRNA turnover.
New
Großhans et al., Basel, Switzerland. In Nucleic Acids Res, 20 Feb 2014
An xrn-2 null mutation or loss of XRN2 catalytic activity causes a molting defect and early larval arrest.
The multifunctional RNase XRN2.
Review
New
Großhans et al., Basel, Switzerland. In Biochem Soc Trans, Aug 2013
XRN2 is a 5'→3' exoribonuclease that is evolutionarily conserved in eukaryotes.
XRN 5'→3' exoribonucleases: structure, mechanisms and functions.
Review
New
Green et al., Newark, United States. In Biochim Biophys Acta, Jun 2013
Highly conserved across species, the family is typically represented by one cytoplasmic enzyme (XRN1/PACMAN or XRN4) and one or more nuclear enzymes (XRN2/RAT1 and XRN3).
Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII.
Impact
GeneRIF
Kiernan et al., Montpellier, France. In Cell, 2012
Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR.
Co-transcriptional degradation of aberrant pre-mRNA by Xrn2.
GeneRIF
West et al., Edinburgh, United Kingdom. In Embo J, 2012
Xrn2 associated with and co-transcriptionally degraded nascent beta-globin transcripts. Evidence was provided that many endogenous pre-mRNAs are also co-transcriptionally degraded by Xrn2 when their processing is inhibited by Spliceostatin A.
mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription.
GeneRIF
Bentley et al., Aurora, United States. In Mol Cell, 2012
Xrn2 has a role in control of transcription by RNA polymerase II.
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
GeneRIF
Gromak et al., Oxford, United Kingdom. In Mol Cell, 2011
The results predict that senataxin is required for the resolution of R-loops formed downstream of the poly(A) signal, allowing Xrn2 recruitment and efficient Pol II transcriptional termination.
Arabidopsis thaliana XRN2 is required for primary cleavage in the pre-ribosomal RNA.
GeneRIF
Kufel et al., Warsaw, Poland. In Nucleic Acids Res, 2010
AtXRN2 has a role in ribosomal RNA processing.
MicroRNAses and the regulated degradation of mature animal miRNAs.
Review
Chatterjee et al., Basel, Switzerland. In Adv Exp Med Biol, 2009
Initially thought to be very stable with half-lives on the order of days, mature miRNAs have recently been shown to be subject to degradation by 'microRNases' (miRNases) in plants (the small RNA degrading nucleases, SDN) and animals (exoribonuclease 2/XRN-2/XRN2).
Turnover of mature miRNAs and siRNAs in plants and algae.
Review
Ibrahim et al., Lincoln, United States. In Adv Exp Med Biol, 2009
Recent studies in Arabidopsis thaliana and Caenorhabditis elegans have implicated 3'-to-5' (SDNs) and 5'-to-3' (XRN-2) exoribonucleases in mature miRNA turnover and the modulation of small RNA levels and activity.
Active turnover modulates mature microRNA activity in Caenorhabditis elegans.
Impact
Grosshans et al., Basel, Switzerland. In Nature, 2009
Here we report that degradation of mature miRNAs in the nematode Caenorhabditis elegans, mediated by the 5'-->3' exoribonuclease XRN-2, affects functional miRNA homeostasis in vivo.
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.
Impact
Tong et al., New York City, United States. In Nature, 2009
XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14).
A ribonucleolytic rat torpedoes RNA polymerase II.
Impact
Bentley et al., Aurora, United States. In Cell, 2005
Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2).
Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.
Impact
GeneRIF
Proudfoot et al., Oxford, United Kingdom. In Nature, 2004
co-transcriptional cleavage acts as a precursor to termination by presenting a free RNA 5' end that is recognized by the human 5' --> 3' exonuclease Xrn2
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