Rotavirus disrupts cytoplasmic P bodies during infection.
Calcutta, India. In Virus Res, Jan 2016
The disruption occurred by more than one different mechanism where deadenylating P body component Pan3 was degraded by rotavirus NSP1 and exonuclease XRN1 along with the decapping enzyme hDCP1a were relocalized from cytoplasm to nucleus.
Dengue Non-coding RNA: TRIMmed for Transmission.
Wageningen, Netherlands. In Cell Host Microbe, Sep 2015
Dengue virus RNA is trimmed by the 5'→3' exoribonuclease XRN1 to produce an abundant, non-coding subgenomic flavivirus RNA (sfRNA) in infected cells.
Functional non-coding RNAs derived from the flavivirus 3' untranslated region.
Brisbane, Australia. In Virus Res, Sep 2015
In this review we summarize published data from studies with WNV, YFV, DENV, JEV, and MVEV on sfRNA production following incomplete degradation of the viral genomic RNA by the cellular 5'-3' exoribonuclease 1 (XRN1), RNA structural elements involved in stalling XRN1 to generate sfRNA, and functions of sfRNA in modulating cellular mRNA decay and RNAi pathways as well as in modulating anti-viral type I interferon response.