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Excision repair cross-complementing rodent repair deficiency, complementation group 5

This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: XPD, XPC, rad1, XPA, ERCC1
Papers on XPG
Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population.
Lazar et al., Târgu-Mureş, Romania. In Tumour Biol, Feb 2016
UNASSIGNED: XPC, XPD, XPF, and XPG genes are implicated in the nucleotide excision repair (NER) system.
Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin.
D'Incalci et al., Milano, Italy. In Br J Cancer, Jan 2016
Resistant cells were found to be hypersensitive to UV light and did not express specific proteins involved in the nucleotide excision repair (NER) pathway: XPF and ERCC1 in 402-91/T and XPG in A2780/T.
Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Lilley et al., Dundee, United Kingdom. In Cell Rep, Jan 2016
The structure of the GEN1 protein reveals it to have an elaborated FEN-XPG family fold that is modified for its role in four-way junction resolution.
Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
Biertümpfel et al., Martinsried, Germany. In Elife, Jan 2016
The GEN1 core is similar to other Rad2/XPG nucleases.
The UVS9 gene of Chlamydomonas encodes an XPG homolog with a new conserved domain.
Petersen et al., Brookings, United States. In Dna Repair (amst), Dec 2015
In this work, the UVS9 gene was cloned through molecular mapping and shown to encode a homolog of XPG, the structure-specific nuclease responsible for cleaving damaged DNA strands 3' to sites of damage during NER.
Xeroderma pigmentosa: three new cases with an in depth review of the genetic and clinical characteristics of the disease.
Shehata et al., Atlanta, United States. In Fetal Pediatr Pathol, Apr 2015
Seven genes (XPA-XPG) have a defect in Nucletoide Excision Repair (NER), while the eighth gene XPV has a defect in polymerase η, which is responsible for replication of UV-damaged DNA to produce corrected daughter strands.
Overview of xeroderma pigmentosum proteins architecture, mutations and post-translational modifications.
Bonatto et al., Porto Alegre, Brazil. In Mutat Res Rev Mutat Res, 2015
The xeroderma pigmentosum complementation group proteins (XPs), which include XPA through XPG, play a critical role in coordinating and promoting global genome and transcription-coupled nucleotide excision repair (GG-NER and TC-NER, respectively) pathways in eukaryotic cells.
Quantitative assessment of the association between XPG Asp1104His polymorphism and bladder cancer risk.
Wang et al., Shanghai, China. In Tumour Biol, 2014
Published data regarding the association between XPG Asp1104His polymorphism and bladder cancer risk remained controversial.
Gastric cancer: epidemiologic aspects.
Rokkas et al., Barcelona, Spain. In Helicobacter, 2013
Large meta-analyses confirmed the association between IL8, IL10, TNF-b, TP53 and PSCA, while genetic variation at different genes such as XPG, PLCE1, HFE, ERCC5, EZH2, DOC2, CYP19A1, ALDH2, and CDH1 have been reported to be associated with GC risk.
Oxidative DNA damage and nucleotide excision repair.
Luijten et al., Leiden, Netherlands. In Antioxid Redox Signal, 2013
The XPG protein is also of importance for the removal of oxidative DNA lesions, as it may enhance the initial step of BER.
Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations.
Li et al., Shanghai, China. In Hum Genet, 2012
study provided statistical evidence that the XPG rs873601 SNP, which has an effect on the gene expression in a recessive manner, was associated with risk for gastric cancer among an Eastern Chinese population.
DNA repair genes polymorphism (XPG and XRCC1) and association of prostate cancer in a north Indian population.
Mahdi et al., Gonder, Ethiopia. In Mol Biol Rep, 2012
Statistically significant increased risk of prostate cancer was observed on individuals that possess the His/His genotype of Asp 1104His of XPG.
Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck.
Wei et al., Houston, United States. In Pharmacogenet Genomics, 2012
These findings suggest that genetic variation in ERCC5 may not affect the risk of SCCHN, although rs4150351 C variant genotypes were associated with an increased expression of ERCC5 mRNA and nonsignificantly decreased risk of SCCHN
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.
Cooper et al., Berkeley, United States. In Cell Cycle, 2011
novel function for XPG in S phase that is, at least in part, performed coordinately with WRN, and which may contribute to the severity of the phenotypes that occur upon loss of XPG.
Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Beese et al., Durham, United States. In Cell, 2011
It is a member of the 5' structure-specific nuclease family of exonucleases and endonucleases that includes FEN-1, XPG, and GEN1.
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.
Tainer et al., Berkeley, United States. In Cell, 2011
FEN1 5' nuclease superfamily members acting in nucleotide excision repair (XPG), mismatch repair (EXO1), and homologous recombination (GEN1) paradoxically incise structurally distinct bubbles, ends, or Holliday junctions, respectively.
The effect of tobacco, XPC, ERCC2 and ERCC5 genetic variants in bladder cancer development.
Ouerhani et al., Tunisia. In Bmc Cancer, 2010
The XPC, ERCC2 and ERCC5 variants don't affect the tumors stage and grade.
Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
Tainer et al., Los Angeles, United States. In Nature, 2009
Genetic connections to mammalian XPG (also known as ERCC5) and ERCC1 in S. pombe homologues Rad13 and Swi10 and biochemical interactions with Escherichia coli UvrA and UvrC combined with structural results reveal that ATLs sculpt alkylated DNA to create a genetic and structural intersection of base damage processing with nucleotide excision repair.
Identification of Holliday junction resolvases from humans and yeast.
West et al., London, United Kingdom. In Nature, 2008
The eukaryotic Holliday junction resolvases represent a new subclass of the Rad2/XPG family of nucleases.
ERCC5 is a novel biomarker of ovarian cancer prognosis.
Karlan et al., Los Angeles, United States. In J Clin Oncol, 2008
ERCC5 was identified as a candidate gene in this region because of its known function in the nucleotide excision repair pathway, the unique DNA repair pathway that removes platinum-DNA adducts.
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