Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues.
Shanghai, China. In Oncotarget, Feb 2016
Accordingly, YM155 treatment significantly decreased survivin expression without affecting XIAP expression and increased the cleavage of apoptosis-associated proteins caspase 3, 7, 8, 9. YM155 significantly inhibited sphere formation of gastric cancer cells, suppressed expansion and growth of the formed spheres (cancer stem cell-like cells, CSCs) and downregulated the protein levels of β-catenin, c-Myc, Cyclin D1 and CD44 in gastric cancer cells.
Membrane microparticles: shedding new light into cancer cell communication.
Rio de Janeiro, Brazil. In J Cancer Res Clin Oncol, Sep 2015
Several oncogenic molecules have been identified inside MPs, including soluble proteins XIAP, survivin, metalloproteinases, CX3CL1, PYK2 and other microRNA-related proteins; membrane proteins EGFR, HER-2, integrins and efflux pumps; and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others.
Thyroid hormone and anti-apoptosis in tumor cells.
Taipei, Taiwan. In Oncotarget, Jul 2015
The hormone also decreases cellular abundance and activation of proteolytic caspases and of BAX and causes increased expression of X-linked inhibitor of apoptosis (XIAP).
The Accomplices of NF-κB Lead to Radioresistance.
More papers using
Beijing, China. In Curr Protein Pept Sci, 2014
Moreover, we describe how the expression of the target genes (e.g., XIAP, A20, FLIP, Bcl-xL) are induced by NF-κB to regulate the activation of survival signaling pathways and to inhibit apoptotic signaling pathways.
Autophagic programmed cell death by selective catalase degradation
In Evidence-based Complementary and Alternative Medicine : eCAM, 2005
... Antibodies against Bcl-2, Bax, Bad, Bcl-xL, XIAP, procaspase 3, procaspase 8, and procaspase 9 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...