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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

X-linked inhibitor of apoptosis

XIAP, xXIAP
Top mentioned proteins: PrP, bcl-2, caspase-3, V1a, CAN
Papers using XIAP antibodies
Efficient RNA interference in patientśacute lymphoblastic leukemia cells amplified as xenografts in mice
Supplier
Jeremias I et al., In Cell Death & Disease, 2011
... (Danvers, MA, USA); anti α-Tubulin from Oncogene (San Diego, CA, USA); anti caspase-9 and anti XIAP from BD Biosciences (San Jose, SA, USA); ...
Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme*
Supplier
Martin Seamus J. et al., In The Journal of Biological Chemistry, 2008
... Caspase-2, caspase-3, caspase-6, caspase-7, BID, gelsolin, RhoGDI, ROCKI, and XIAP antibodies were purchased from BD Biosciences (catalog nos ...
Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (apaf-1) inhibitors
Supplier
Pérez-Payá E et al., In Cell Death & Disease, 2007
... caspase-9 (No.9508), phospho-Chk1 (No.23425), GAPDH (No.2018), γ-H2Ax (Ser 139; No.9718S), cIAP1 (No.4952), Mcl-1 (No.4572) and XIAP (No.2042) were from Cell Signaling (Danvers, MA, USA) ...
A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo.
Supplier
Chandra Dhyan, In PLoS ONE, 2006
... The XIAP antibody was obtained from Abcam and actin from Sigma ...
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Papers on XIAP
MicroRNA-509-3p increases the sensitivity of epithelial ovarian cancer cells to cisplatin-induced apoptosis.
New
Jiang et al., Guangzhou, China. In Pharmacogenomics, Feb 2016
AIMS: XIAP is upregulated in chemoresistant epithelial ovarian cancer (EOC).
MicroRNA-155 promotes apoptosis in SKOV3, A2780, and primary cultured ovarian cancer cells.
New
He et al., Guangzhou, China. In Tumour Biol, Feb 2016
Bioinformatic predictions, the dual-luciferase reporter assay, and western blot analysis were used to detect how miR-155 regulates X-linked inhibitor of apoptosis protein (XIAP).
Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues.
New
Tu et al., Shanghai, China. In Oncotarget, Feb 2016
Accordingly, YM155 treatment significantly decreased survivin expression without affecting XIAP expression and increased the cleavage of apoptosis-associated proteins caspase 3, 7, 8, 9. YM155 significantly inhibited sphere formation of gastric cancer cells, suppressed expansion and growth of the formed spheres (cancer stem cell-like cells, CSCs) and downregulated the protein levels of β-catenin, c-Myc, Cyclin D1 and CD44 in gastric cancer cells.
The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer.
New
Jan et al., Rennes, France. In Oncotarget, Feb 2016
Whole transcriptomic analysis demonstrated that propionibacterial supernatant or propionibacterial metabolites (propionate and acetate), in combination with TRAIL, increased pro-apoptotic gene expression (TRAIL-R2/DR5) and decreased anti-apoptotic gene expression (FLIP, XIAP) in HT29 human colon cancer cells.
Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes.
New
Datta et al., Karnāl, India. In Domest Anim Endocrinol, Dec 2015
FSH supplementation in in vitro maturation-medium resulted in a dose-dependent reduction in the expression of proapoptotic genes namely, BCL2-associated X protein (BAX), cytochrome c, and caspase-3 and increase in the expression of antiapoptotic genes such as B-cell lymphoma 2 (BCL2) and X-linked inhibitor of apoptosis protein (XIAP) in cumulus cells of mature oocyte.
Membrane microparticles: shedding new light into cancer cell communication.
Review
New
Maia et al., Rio de Janeiro, Brazil. In J Cancer Res Clin Oncol, Sep 2015
Several oncogenic molecules have been identified inside MPs, including soluble proteins XIAP, survivin, metalloproteinases, CX3CL1, PYK2 and other microRNA-related proteins; membrane proteins EGFR, HER-2, integrins and efflux pumps; and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others.
A potential role of X-linked inhibitor of apoptosis protein in mitochondrial membrane permeabilization and its implication in cancer therapy.
Review
New
Chandra et al., Buffalo, United States. In Drug Discov Today, Aug 2015
UNASSIGNED: X-chromosome-linked inhibitor of apoptosis protein (XIAP) has an important regulatory role in programmed cell death by inhibiting the caspase cascade.
Thyroid hormone and anti-apoptosis in tumor cells.
Review
New
Davis et al., Taipei, Taiwan. In Oncotarget, Jul 2015
The hormone also decreases cellular abundance and activation of proteolytic caspases and of BAX and causes increased expression of X-linked inhibitor of apoptosis (XIAP).
The Accomplices of NF-κB Lead to Radioresistance.
Review
Han et al., Beijing, China. In Curr Protein Pept Sci, 2014
Moreover, we describe how the expression of the target genes (e.g., XIAP, A20, FLIP, Bcl-xL) are induced by NF-κB to regulate the activation of survival signaling pathways and to inhibit apoptotic signaling pathways.
Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists.
Review
Lacasse et al., Ottawa, Canada. In Int J Dev Biol, 2014
Small molecule antagonists that target specific IAP oncoproteins, primarily cIAP1 and cIAP2, but potentially also XIAP and Livin, modulate distinct immune signal transduction pathways that can lead to an increased sensitivity of tumors cells to cytokine-mediated apoptosis.
Sept4/ARTS regulates stem cell apoptosis and skin regeneration.
Impact
Steller et al., New York City, United States. In Science, 2013
Inactivation of XIAP, a direct target of ARTS, abrogated these phenotypes and impaired wound healing.
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.
Impact
Pandolfi et al., Boston, United States. In Nat Genet, 2013
Mechanistically, the integrated acquisition of data from mouse models and patients identifies the expression patterns of XAF1, XIAP and SRD5A1 as a predictive and actionable signature for CRPC.
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.
Impact
Tschopp et al., Lausanne, Switzerland. In Immunity, 2012
To determine whether IL-1β activation is regulated by inhibitor of apoptosis (IAP) proteins, we treated macrophages with an IAP-antagonist "Smac mimetic" compound or genetically deleted the genes that encode the three IAP family members cIAP1, cIAP2, and XIAP.
Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma.
Impact
Wierda et al., Houston, United States. In J Clin Oncol, 2010
Biomarker analyses demonstrated mechanism-based PD activity with inhibition of Cdk7 and Cdk9, decreases in Mcl-1 and XIAP expression level, and associated CLL cell apoptosis.
Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.
Impact
Sheng et al., Cambridge, United States. In Cell, 2010
LTD is also prevented by overexpression of the anti-apoptotic proteins XIAP or Bcl-xL, and by a mutant Akt1 protein that is resistant to caspase-3 proteolysis.
More papers using XIAP antibodies
Autophagic programmed cell death by selective catalase degradation
Supplier
Choi Yung Hyun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2005
... Antibodies against Bcl-2, Bax, Bad, Bcl-xL, XIAP, procaspase 3, procaspase 8, and procaspase 9 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Treatment of hormone-refractory breast cancer: apoptosis and regression of human tumors implanted in mice.
Supplier
El-Rifai Wael, In PLoS ONE, 2005
... Signaling (Beverly, MA); anti-survivin antibody was from Novus Biologicals; antibody against X-linked inhibitor of apoptosis (XIAP) was from BD Biosciences.
Down-regulation of XIAP expression induces apoptosis and enhances chemotherapeutic sensitivity in human gastric cancer cells
Supplier
Kim Sun Hyo et al., In Nutrition Research and Practice, 2004
... cleaved caspase-9, cleaved poly (ADP-ribose) polymerase (PARP), caspase-8, Bid, and X-linked inhibitor of apoptosis protein (XIAP) were obtained from Cell Signaling Technology (Beverly, MA, USA); ...
Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases
Supplier
Park Jung Han Yoon et al., In BMC Gastroenterology, 2003
... caspase-9, cleaved poly (ADP-ribose) polymerase (PARP), caspase-8, Bid, survivin, and X-linked inhibitor of apoptosis protein (XIAP) (Cell Signaling Technology, Beverly, MA, USA); ...
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
Supplier
Schneider Guenter, In PLoS ONE, 2003
... against the following proteins were used for Western blot analyses: survivin (Abcam, Cambridge, MA, USA); XIAP (BD Biosciences, San Jose, CA, USA); ...
Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis
Supplier
Ohlmann Andreas, In PLoS ONE, 2002
... c, caspase-2L and -2S, survivin, Bcl-2, RAIDD and PIDD as well as monoclonal mouse anti-human XIAP, hnRNP A1 and SF2/ASF antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
Mitochondrial control of cell death.
Supplier
Gartel Andrei L., In PLoS ONE, 1999
... Cytochrome c oxidase sub unit IV (Cox IV) and X-linked inhibitor of apoptosis protein (XIAP) antibodies were purchased from Cell Signaling Technology, Inc (Danvers, MA, ...
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
Supplier
Yang Bo et al., In Journal of Biomedicine and Biotechnology, 1996
... Appropriate antibodies to cleaved caspase-3, Smac and XIAP from Cell Signaling Technology (Beverly, MA) and ...
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