Interleukin 1β regulation of the system xc- substrate-specific subunit, xCT, in primary mouse astrocytes involves the RNA-binding protein HuR.
Syracuse, United States. In J Biol Chem, Dec 2015
We recently determined that the cytokine, IL-1β, increases the activity of system xc (-) in CNS astrocytes secondary to an upregulation of its substrate-specific light chain, xCT, and that this occurs, in part, at the level of transcription.
Iron and thiols as two major players in carcinogenesis: friends or foes?
Nagoya, Japan. In Front Pharmacol, 2013
It is now recognized that the cystine/glutamate transporter (antiporter) is intimately associated with ferroptosis, an iron-dependent, non-apoptotic form of cell death, observed in cancer cells, and also with cancer stem cells; the former with transporter blockage but the latter with its stabilization.
Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis.
Nara, Japan. In Biomed Rep, 2013
HNF-1β regulates tissue-specific gene expression in endometriosis, as well as the expression of several genes, including CD44v9, which binds several molecules, including hyaluronan, epidermal growth factor receptor (EGFR), leukemia-associated Rho-guanine nucleotide exchange factor (LARG), IQ motif containing GTPase activating protein 1 (IQGAP1), macrophage migration inhibitory factor (MIF), major histocompatibility complex, class II invariant chain (CD74), cystine transporter subunit (xCT), Fas and extracellular matrix (ECM) proteins.