Cell death induced by endoplasmic reticulum stress.
l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
Central to the unfolded protein response are the sensors PERK, IRE1 and ATF6, as well as other signaling nodes such as c-Jun N-terminal kinase 1 (JNK) and the downstream transcription factors XBP1, ATF4 and CHOP.
Molecular biology of the stress response in the early embryo and its stem cells.
Detroit, United States. In Adv Exp Med Biol, 2014
Some of the transcription factors (TFs) that are most important in the stress response are JunC, JunB, MAPKAPs, ATF4, XBP1, Oct1, Oct4, HIFs, Nrf2/KEAP, NFKB, MT1, Nfat5, HSF1/2 and potency-maintaining factors Id2, Cdx2, Eomes, Sox2, Nanog, Rex1, and Oct4.