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X-box binding protein 1

XBP1, X-box binding protein 1
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CHOP, GRP78, IRE1, CAN, V1a
Papers on XBP1
Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response.
Nutt et al., Australia. In Nat Immunol, Feb 2016
Blimp-1 regulated many components of the unfolded protein response (UPR), including XBP-1 and ATF6.
Ingestion of a natural mineral-rich water in an animal model of metabolic syndrome: effects in insulin signalling and endoplasmic reticulum stress.
Martins et al., In Horm Mol Biol Clin Investig, Feb 2016
Additionally, unspliced-XBP1 increased with mineral-rich water.
Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons.
Lester et al., Pasadena, United States. In J Neurosci, Feb 2016
We evoked mild endoplasmic reticulum (ER) stress with tunicamycin (Tu), producing modest increases in the level of nuclear ATF6, phosphorylated eukaryotic initiation factor 2α, nuclear XBP1, and the downstream proapoptotic effector nuclear C/EBP homologous protein.
A synthetic chalcone, 2'-hydroxy-2,3,5'-trimethoxychalcone triggers unfolded protein response-mediated apoptosis in breast cancer cells.
Shin et al., Seoul, South Korea. In Cancer Lett, Jan 2016
In addition, UPR-related transcription factors, XBP-1 and CHOP, were activated by DK143.
Activation of IRE1α-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma.
Zheng et al., Wenzhou, China. In Biochem Biophys Res Commun, Jan 2016
IRE1α-XBP1 pathway is the most conserved UPR pathways, which are activated during ER stress caused by the accumulation of unfolded or misfolded protein in the lumen of ER.
Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults.
Hamburg et al., Boston, United States. In J Am Heart Assoc, Dec 2015
In PBMCs, ATF6 and spliced X-box-binding protein 1 (XBP-1) gene expression increased by 2.0- and 2.5-fold, respectively (both P<0.05), whereas CHOP and GADD34 decreased by ≈67% and 74%, respectively (both P<0.01).
Cell death induced by endoplasmic reticulum stress.
Muñoz-Pinedo et al., l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
Central to the unfolded protein response are the sensors PERK, IRE1 and ATF6, as well as other signaling nodes such as c-Jun N-terminal kinase 1 (JNK) and the downstream transcription factors XBP1, ATF4 and CHOP.
The transcription factor XBP1 is selectively required for eosinophil differentiation.
Glimcher et al., Boston, United States. In Nat Immunol, Aug 2015
The transcription factor XBP1 has been linked to the development of highly secretory tissues such as plasma cells and Paneth cells, yet its function in granulocyte maturation has remained unknown.
METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.
Hotamisligil et al., Boston, United States. In Science, Aug 2015
Here, we show that, in the setting of obesity, inflammatory input through increased inducible nitric oxide synthase (iNOS) activity causes S-nitrosylation of a key UPR regulator, IRE1α, which leads to a progressive decline in hepatic IRE1α-mediated XBP1 splicing activity in both genetic (ob/ob) and dietary (high-fat diet-induced) models of obesity.
Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases.
Koong et al., Stanford, United States. In Semin Cancer Biol, Aug 2015
As the most conserved signaling branch of the UPR, the IRE1α-XBP1 pathway plays important roles in both physiological and pathological settings and its activity has profound effects on disease progression and prognosis.
Endoplasmic reticulum quality control in cancer: Friend or foe.
Qi et al., Ithaca, United States. In Semin Cancer Biol, Aug 2015
Here we review recent advances in our understanding of the complex relationship between ER proteostasis and cancer pathology, with a focus on the two most conserved ER quality-control mechanisms--the IRE1α-XBP1 pathway of the UPR and SEL1L-HRD1 complex of the ERAD.
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.
Glimcher et al., New York City, United States. In Cell, Jul 2015
The endoplasmic reticulum (ER) stress response factor XBP1 promotes intrinsic tumor growth directly, but whether it also regulates the host anti-tumor immune response is not known.
ER Stress in Dendritic Cells Promotes Cancer.
Pittet et al., Boston, United States. In Cell, Jul 2015
XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth.
Molecular biology of the stress response in the early embryo and its stem cells.
Rappolee et al., Detroit, United States. In Adv Exp Med Biol, 2014
Some of the transcription factors (TFs) that are most important in the stress response are JunC, JunB, MAPKAPs, ATF4, XBP1, Oct1, Oct4, HIFs, Nrf2/KEAP, NFKB, MT1, Nfat5, HSF1/2 and potency-maintaining factors Id2, Cdx2, Eomes, Sox2, Nanog, Rex1, and Oct4.
Mechanisms of Microbe-Host Interaction in Crohn's Disease: Dysbiosis vs. Pathobiont Selection.
Haller et al., Freising, Germany. In Front Immunol, 2014
New hypothesis-driven mouse models, e.g., epithelial-specific Caspase8(-/-), ATG16L1(-/-), and XBP1(-/-) mice, validate pathway-focused function of specific CD-associated risk genes highlighting the role of Paneth cells in antimicrobial defense.
SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.
Puglielli et al., Madison, United States. In J Biol Chem, 2012
IRE1/XBP1 controls the induction of autophagy/ERAD(II) during the unfolded protein response by activating the ER membrane transporter SLC33A1/AT-1
Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.
Eizirik et al., Brussels, Belgium. In Endocrinology, 2012
Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1beta in pancreatic rat beta-cells via the IRE1alpha/XBP1s pathway
Protective effects of XBP1 against oxygen and glucose deprivation/reoxygenation injury in rat primary hippocampal neurons.
Sokabe et al., Tokushima, Japan. In Neurosci Lett, 2012
Found that suppression of XBP1 activation accelerates neuronal cell death after ischemia/reperfusion.
Inhibition of enterovirus 71 entry by transcription factor XBP1.
Lau et al., Taiwan. In Biochem Biophys Res Commun, 2012
the inhibition of XBP1s by viral infection may underlie viral entry.
AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease.
Hetz et al., Santiago, Chile. In Biochem Biophys Res Commun, 2012
a significant reduction in the accumulation of Htt588(Q95)-mRFP intracellular inclusion was observed when XBP1 was co-expressed in the striatum.
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